Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Damijan Knez"'
Autor:
Luka Rejc, Damijan Knez, Gabriela Molina-Aguirre, Alba Espargaró, Jerneja Kladnik, Anže Meden, Lana Blinc, Matic Lozinšek, Ross D. Jansen-van Vuuren, Matic Rogan, Bruno Aleksander Martek, Jernej Mlakar, Ana Dremelj, Andrej Petrič, Stanislav Gobec, Raimon Sabaté, Mara Bresjanac, Balazs Pinter, Janez Košmrlj
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116616- (2024)
Fluorescent probes are a powerful tool for imaging amyloid β (Aβ) plaques, the hallmark of Alzheimer’s disease (AD). Herein, we report the synthesis and comprehensive characterization of 21 novel probes as well as their optical properties and bin
Externí odkaz:
https://doaj.org/article/5dba3452cc3d4596945a7835ff379451
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Autor:
Lana Blinc, Mateja Drolec Novak, Jernej Mlakar, Damijan Knez, Matic Rogan, Jerneja Kladnik, Ross Jansen-Van Vuuren, Janez Košmrlj, Maja Bresjanac
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S371- (2023)
Externí odkaz:
https://doaj.org/article/b88cf8f835b64d8bb4ec89d393ddcc3c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112924- (2022)
Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the nervous system. Alzheimer’s and Parkinson’s diseases are the most common neurodegenerative disorders, and t
Externí odkaz:
https://doaj.org/article/98c47b3d773b46e5b4de77055bb3c243
Autor:
Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 129 (2023)
Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a
Externí odkaz:
https://doaj.org/article/702c0522a57541afa9b3f4fa4a2bc548
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Autor:
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal str
Externí odkaz:
https://doaj.org/article/dbf12d5fe8ba43da9d6b77ed1a105af9
Autor:
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György M. Keserű
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1484 (2022)
Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electr
Externí odkaz:
https://doaj.org/article/df22a37fca3f4388a828d755b3209126
Autor:
Óscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Molecules, Vol 27, Iss 21, p 7437 (2022)
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typi
Externí odkaz:
https://doaj.org/article/8078d56a965e4cc89b09a239954326f4
Autor:
Daniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1735 (2022)
Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a
Externí odkaz:
https://doaj.org/article/36d7147103e34c51ab45e8dc9f4cb39c
Publikováno v:
Molecules, Vol 27, Iss 14, p 4484 (2022)
Open innovation initiatives provide opportunities for collaboration and sharing of knowledge and experience between industry, academia, and government institutions. Through open innovation, Merck is offering a Mini Library of 80 carefully selected co
Externí odkaz:
https://doaj.org/article/50d7ea6019e5464e99252dd8f5406b1c