Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Damien W. Gulliver"'
Autor:
Damien W. Gulliver, Tristan A. Reekie, William T. Jorgensen, Eryn L. Werry, Timothy A. Katte, Michael Kassiou
Publikováno v:
Trends in Pharmacological Sciences. 40:22-37
Deficits in social behavioral domains, such as interpersonal communication, emotion recognition, and empathy, are a characteristic symptom in several neuropsychiatric disorders, including schizophrenia and autism spectrum disorder (ASD). The neuropep
Autor:
Mark Connor, Eryn L. Werry, Damien W. Gulliver, William T. Jorgensen, Timothy A. Katte, Michael Kassiou, Tristan A. Reekie
Publikováno v:
European Journal of Medicinal Chemistry. 143:1644-1656
WAY-267,464 (1) and twelve conformationally rigid analogues (3a-f–4a-f) were synthesised, characterised and evaluated in cellular assays with the aim of systematically exploring interactions with the oxytocin receptor (OTR). Each analogue was evalu
Autor:
Timothy A. Katte, Michael Kassiou, Eryn L. Werry, Mark Connor, Rochelle Boyd, William T. Jorgensen, Erick C.N. Wong, Tristan A. Reekie, Damien W. Gulliver
Publikováno v:
European journal of medicinal chemistry. 136
The neuropeptide oxytocin has been implicated in multiple central nervous system functions in mammalian species. Increased levels have been reported to improve trust, alleviate symptoms related to autism and social phobias, and reduce social anxiety.
Autor:
Michael Kassiou, Erick C.N. Wong, William T. Jorgensen, Mark Connor, Taylor Garrett, Kiyan Afzali, Oludamilola Awofala, Eryn L. Werry, Damien W. Gulliver, Tristan A. Reekie
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-1
Autor:
Michael Kassiou, William T. Jorgensen, Tristan A. Reekie, Timothy A. Katte, Damien W. Gulliver, Eryn L. Werry
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-1
Autor:
Damien W. Gulliver, Eryn L. Werry, William T. Jorgensen, Mark Connor, Tristan A. Reekie, Michael Kassiou
Publikováno v:
European journal of medicinal chemistry. 108
A previously identified, non-peptidic oxytocin (OT) receptor agonist WAY-267,464 (1) and nine novel derivatives (3, 4a-7a, 4b-7b) were synthesised and evaluated in vitro with the aim of systematically exploring hydrogen bonding interactions and ligan