Výsledky vyhledávání - "Damien Toulorge"

Akademický článek

CD38 in Neurodegeneration and Neuroinflammation

Autor: Serge Guerreiro, Anne-Laure Privat, Laurence Bressac, Damien Toulorge

Publikováno v: Cells, Vol 9, Iss 2, p 471 (2020)

Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneratio

Externí odkaz: https://doaj.org/article/33c61c72ae934127b8512919c3517b69

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Molecular changes in the postmortem parkinsonian brain

Autor: Anthony H.V. Schapira, Damien Toulorge, Rodolphe Hajj

Publikováno v: Journal of Neurochemistry. 139:27-58

Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become clear that its etiological basis is broad. Post-mortem brain analysis, despite i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878bd002f51b082e0773542b4ec8b76f
https://doi.org/10.1111/jnc.13696

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Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease

Autor: Patrick P. Michel, Serge Guerreiro, Damien Toulorge, Etienne C. Hirsch

Publikováno v: The FASEB Journal. 27:3414-3423

Parkinson disease (PD) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although our knowledge of the mechanisms that contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e43a8b1d5169c05f4441fc590a133
https://doi.org/10.1096/fj.12-220418

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KATP channel blockade protects midbrain dopamine neurons by repressing a glia-to-neuron signaling cascade that ultimately disrupts mitochondrial calcium homeostasis

Autor: Serge Guerreiro, Etienne C. Hirsch, Patrick P. Michel, Damien Toulorge

Publikováno v: Journal of Neurochemistry. 114:553-564

While K(ATP) channels serve primarily as metabolic gatekeepers in excitable cells, they might also participate in other important cellular functions. Here, we demonstrate that K(ATP) channel blockade with the sulfonylurea derivative glibenclamide pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9410bc78b91e22d1365e5fd26a0a2785
https://doi.org/10.1111/j.1471-4159.2010.06785.x

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Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization

Autor: Serge Guerreiro, Damien Toulorge, Patrick P. Michel, Daniel Alvarez-Fischer, Etienne C. Hirsch, Aurélie Ponceau, Elodie Martin

Publikováno v: Journal of Neurochemistry. 109:1118-1128

High plasma levels of the end product of purine metabolism uric acid (UA) predict a reduced risk of developing Parkinson's disease suggesting that UA may operate as a protective factor for midbrain dopaminergic neurons. Consistent with this view, UA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74c28ed2038d61019c24a1435904fdd
https://doi.org/10.1111/j.1471-4159.2009.06040.x

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Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson’s disease

Autor: Julie Foucquier, Sandra Robelet, Mickaël Guedj, Julien Laffaire, Ilya Chumakov, Daniel Cohen, Rodolphe Hajj, Richard Mitry, Damien Toulorge, Nathalie Cholet, Serguei Nabirotchkin, Aude Milet

Publikováno v: Scientific Reports

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic nigrostriatal neurons but which involves the loss of additional neurotransmitter pathways. Mono- or polytherapeutic interventions in PD p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871c8f4a6e1cc8a95f2212739c5cb9fe

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Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

Autor: Emmanuel Vial, Damien Toulorge, Nathalie Cholet, Yannick Pereira, Rémy Steinschneider, Esther Graudens, Tangui Maurice, Julie Foucquier, Rodolphe Hajj, Ilya Chumakov, Serguei Nabirotchkin, Aude Milet, Daniel Cohen, Catherine Scart-Grès, Aurélie Boucard, Noelle Callizot, Mickaël Guedj, Sory Traoré, Viviane Bertrand

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep07608⟩
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep07608⟩

Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97b170dd001135da9749208d50aa097
https://hal.archives-ouvertes.fr/hal-01922611

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Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca 2+

Autor: Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C. Hirsch, Patrick P. Michel, Damien Toulorge

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25 (8), pp.2563-2573. ⟨10.1096/fj.11-182824⟩
FASEB Journal, 2011, 25 (8), pp.2563-2573. ⟨10.1096/fj.11-182824⟩

International audience; Epidemiological and experimental evidence indicates that nicotine is protective for Parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this effect remains only partly characterized. To address this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe983786ed6f0f549846665d2f38a730
https://hal-pasteur.archives-ouvertes.fr/pasteur-02936389

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