Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Damien Reynaud"'
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Autor:
Sandra Schrenk, Lindsay J. Bischoff, Jillian Goines, Yuqi Cai, Shruti Vemaraju, Yoshinobu Odaka, Samantha R. Good, Joseph S. Palumbo, Sara Szabo, Damien Reynaud, Catherine D. Van Raamsdonk, Richard A. Lang, Elisa Boscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of
Externí odkaz:
https://doaj.org/article/7cad600490c342d6b140a087bcb306ca
Autor:
Jasmine C Wong, Kelley M Weinfurtner, Maria del pilar Alzamora, Scott C Kogan, Michael R Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Theodore T Ho, Johanna Flach, Damien Reynaud, Emmanuelle Passegué, James R Downing, Kevin Shannon
Publikováno v:
eLife, Vol 4 (2015)
Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 synt
Externí odkaz:
https://doaj.org/article/22ff762d87894c87b32f30861437c04b
Autor:
Vinothini Govindarajah, Damien Reynaud
Publikováno v:
Curr Stem Cell Rep
PURPOSE OF REVIEW: Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summ
Autor:
Dr. Jane Koo, Damien Reynaud, Assem Ziady, Seth Kahn, Sheyar Abdullah, Nathan Luebbering, Lauren Strecker, Kelly E Lake, Lucille Giordullo, Azada Ibrahimova, Samantha Good, Dr. Christopher E. Dandoy, Kasiani Myers, Sonata Jodele, Stella M. Davies
Publikováno v:
Transplantation and Cellular Therapy. 29:S134
Autor:
Vinothini Govindarajah, Masahide Sakabe, Samantha Good, Michael Solomon, Nong Chen, Ady Kendler, Mei Xi, Damien Reynaud
Publikováno v:
Blood. 140:2224-2224
Autor:
Jane Koo, Damien Reynaud, Assem Ziady, Lauren Strecker, Nathan Luebbering, Sheyar Abdullah, Alexandra Duell, Kelly E Lake, Emily Skala, Kodandaramireddy Nalapareddy, Michael Solomon, Adam Lane, Sonata Jodele, Stella M. Davies
Publikováno v:
Transplantation and Cellular Therapy. 28:S19-S20
Publikováno v:
Cytometry A
Phenotypic analysis by flow cytometry is one of the most utilized primary tools to study the hematopoietic system. Here, we present a complex panel designed for spectral flow cytometry that allows for the in-depth analysis of the mouse hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8688d40f87f60a336d272d92fccd722f
https://europepmc.org/articles/PMC8630828/
https://europepmc.org/articles/PMC8630828/
Autor:
Vinothini Govindarajah, Nathan Salomonis, Ramesh C. Nayak, Kalpana Nattamai, Damien Reynaud, Jung-Mi Lee, Michael Solomon, Jose A. Cancelas, Bryan Goddard, Hartmut Geiger
Publikováno v:
Blood Adv
Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated wi
Autor:
David E. Muench, Marie-Dominique Filippi, Bryan Goddard, Vinothini Govindarajah, Nathan Salomonis, Ashwini S. Hinge, Jose A. Cancelas, Damien Reynaud, H. Leighton Grimes, Jung-Mi Lee, Bruce J. Aronow
Publikováno v:
The Journal of Experimental Medicine
Lee et al. show that established obesity alters the composition and long-term fitness of the hematopoietic stem cell (HSC) compartment, in part through a Gfi1-dependent HSC regulatory program that is activated by the chronic oxidative stress associat
Autor:
Kerstin Stemmer, Rachel Sheridan, Shiva Kumar Shanmukhappa, Matthew J. Lawson, Rebekah Karns, Maria E. Moreno-Fernandez, Daniel A. Giles, C. Ronald Kahn, Monica Cappelletti, Samir Softic, Simon Graspeuntner, Senad Divanovic, Simon P. Hogan, Kris A. Steinbrecher, Christian Sina, Calvin C. Chan, Yoichiro Iwakura, Annika Sünderhauf, Traci E. Stankiewicz, David Wu, Damien Reynaud, Christopher L. Karp, Jared Klarquist, Jan Rupp, David B. Haslam, Bruce J. Aronow, Rajib Mukherjee
Publikováno v:
Nat. Med. 23, 829-838 (2017)
Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular carcinoma, is the most common chronic liver disease worldwide. Defining the molecular mechanisms underlying the pathogenesis of NAFLD has been hampered by a la