Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Damien R Drew"'
Autor:
Jo-Anne Chan, David Wetzel, Linda Reiling, Kazutoyo Miura, Damien R Drew, Paul R Gilson, David A Anderson, Jack S Richards, Carole A Long, Manfred Suckow, Volker Jenzelewski, Takafumi Tsuboi, Michelle J Boyle, Michael Piontek, James G Beeson
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221733 (2019)
The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, the development of more efficacious vaccines by improving t
Externí odkaz:
https://doaj.org/article/89f4de558b43477eaa92458ca4da6dc1
Autor:
Sheetij Dutta, Lisa S Dlugosz, Damien R Drew, Xiaopeng Ge, Diouf Ababacar, Yazmin I Rovira, J Kathleen Moch, Meng Shi, Carole A Long, Michael Foley, James G Beeson, Robin F Anders, Kazutoyo Miura, J David Haynes, Adrian H Batchelor
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003840 (2013)
Malaria vaccine candidate Apical Membrane Antigen-1 (AMA1) induces protection, but only against parasite strains that are closely related to the vaccine. Overcoming the AMA1 diversity problem will require an understanding of the structural basis of c
Externí odkaz:
https://doaj.org/article/8b57d05c22124733aa9aa5fc66898def
Autor:
Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51023 (2012)
Apical Membrane Antigen 1 (AMA1) is a leading malaria vaccine candidate and a target of naturally-acquired human immunity. Plasmodium falciparum AMA1 is polymorphic and in vaccine trials it induces strain-specific protection. This antigenic diversity
Externí odkaz:
https://doaj.org/article/54726776553c433f9f07b1300513e92e
Autor:
Damien R. Drew, Danny W. Wilson, Gretchen E. Weiss, Lee M. Yeoh, Isabelle G. Henshall, Brendan S. Crabb, Sheetij Dutta, Paul R. Gilson, James G. Beeson
Publikováno v:
Cellular and Molecular Life Sciences. 80
Plasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozo
Autor:
Seong-Kyun, Lee, Leanne M, Low, John F, Andersen, Lee M, Yeoh, Paola Carolina, Valenzuela Leon, Damien R, Drew, Johannes S P, Doehl, Eric, Calvo, Louis H, Miller, James G, Beeson, Karthigayan, Gunalan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
We used a transgenic parasite in which
Autor:
Damien R. Drew, Brian J. Smith, Raphaël Rahmani, Swapna Varghese, James G. Beeson, Jonathan B. Baell, Jake Baum
Publikováno v:
ChemMedChem. 16:679-693
Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occur
Publikováno v:
Evolutionary Applications, Vol 6, Iss 2, Pp 365-376 (2013)
Abstract Parasites may alter their behaviour to cope with changes in the within‐host environment. In particular, investment in transmission may alter in response to the availability of parasite resources or host immune responses. However, experimen
Externí odkaz:
https://doaj.org/article/c28a88d11d4e45099b337a38d5b9d6ef
Autor:
Ying Li, Yu By Sun, Fernando J. Rossello, Jose M. Polo, Phill Pymm, Damien R. Drew, Jessica A. Neil, Jia Ping Tan, Wai-Hong Tham, Guizhi Sun, Yichen Zhou, Kanta Subbarao, Joseph Chen, Raj Rudraraju, Guiying Nie, Xiaodong Liu, Monika Mohenska
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has caused a global health crisis. The primary site of infection is in the respiratory tract but the virus has been associated with a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20073da1f66bf4438d4fb662d16d4b8
https://doi.org/10.1101/2021.10.27.465224
https://doi.org/10.1101/2021.10.27.465224
Autor:
Aung Thi, Nyi Nyi Zaw, Julia C. Cutts, Htin Kyaw Thu, Wai Yan Min Htay, Paul A. Agius, Kyaw Zayar Aung, Alyssa E. Barry, James G. Beeson, Win Han Oo, Julie A. Simpson, Myat Mon Thein, Aung Paing Soe, Zahra Razook, Sophie Zaloumis, Damien R. Drew, Katherine O’Flaherty, Freya J. I. Fowkes, Naanki Parischa
Publikováno v:
BMC Medicine
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Background In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health volunteers (VHVs) reporting the results of rapid diagnostic tests (RDTs), known to miss many asymptomatic infections. Integr
Autor:
Raelene Pickering, Adam K. Wheatley, Michael A. Dengler, Melanie H. Dietrich, Damian F. J. Purcell, Damien R. Drew, Li Lynn Tan, Amy Adair, Hariprasad Venugopal, Ebene R. Haycroft, Miles P. Davenport, Stephen J. Kent, Kanta Subbarao, Wai-Hong Tham, Francesca L Mordant, Matthew T. O'Neill, Ester Lopez, James P Cooney, Dale I. Godfrey, Phillip Pymm, Amy W. Chung, Marc Pellegrini, Nichollas E. Scott, Marcel Doerflinger, Deborah Cromer, Alisa Glukhova, Nicholas A Gherardin, Cody C. Allison, Li-Jin Chan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Neutralizing antibodies are important for immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as therapeutics for the prevention and treatment of COVID-19. We identified high-affinity nanobodies against SARS