Výsledky vyhledávání - "Damien Meng-Kiat Leow"

Akademický článek

Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons

Autor: Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Lucrecia Chen, Yang-Kai Ng, Crystal Jing-Jing Yeo, Barry Halliwell, Wei-Yi Ong

Publikováno v: Antioxidants, Vol 13, Iss 6, p 693 (2024)

Cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson’s disease patients. Ergothioneine (ET), a natural dietary compound, has been shown to have

Externí odkaz: https://doaj.org/article/4e01849889b64fed887664b880bec3b1

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What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson’s Disease?

Autor: Wei-Yi Ong, Damien Meng-Kiat Leow, Deron R. Herr, Crystal Jing-Jing Yeo

Publikováno v: NeuroMolecular Medicine. 25:1-13

Research advances have shed new insight into cellular pathways contributing to PD pathogenesis and offer increasingly compelling therapeutic targets. In this review, we made a broad survey of the published literature that report possible disease-modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f180675bd30c8c9e2c6d051588e678cc
https://doi.org/10.1007/s12017-022-08718-x

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Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells

Autor: Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Zachary Wei-Jie Fong, Barry Halliwell, Wei-Yi Ong

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5498

Recent findings have suggested that the natural compound ergothioneine (ET), which is synthesised by certain fungi and bacteria, has considerable cytoprotective potential. We previously demonstrated the anti-inflammatory effects of ET on 7-ketocholes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e95f1214c3a5fcde1dff8f21d8f0e

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Protective Effect of Ergothioneine Against Stroke in Rodent Models

Autor: Wei-Yi, Ong, Mei-Han, Kao, Wai-Mui, Cheung, Damien Meng-Kiat, Leow, Irwin Kee-Mun, Cheah, Teng-Nan, Lin

Publikováno v: NeuroMolecular Medicine.

Ergothioneine (ET) is a naturally occurring antioxidant and cytoprotective agent that is synthesized by fungi and certain bacteria. Recent studies have shown a beneficial effect of ET on neurological functions, including cognition and animal models o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8113af3c004d6a453562386411433aa6
https://doi.org/10.1007/s12017-022-08727-w

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