Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Damien M. Laudier"'
Autor:
Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M. Laudier, Venetia Zachariou, James C. Iatridis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1762 (2024)
Chronic painful intervertebral disc (IVD) degeneration (i.e., discogenic pain) is a major source of global disability needing improved knowledge on multiple-tissue interactions and how they progress in order improve treatment strategies. This study u
Externí odkaz:
https://doaj.org/article/75d9ffc03fd64012be12f8a682c69cce
Autor:
Zachary S. Gallate, Danielle N. D'Erminio, Philip Nasser, Damien M. Laudier, James C. Iatridis
Publikováno v:
JOR Spine, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Back and neck pain are leading causes of global disability that are associated with intervertebral disc (IVD) degeneration. Causes of IVD degeneration are multifactorial, and diet, age, and diabetes have all been linked to IVD deg
Externí odkaz:
https://doaj.org/article/c4d49ddd72e647b5b8fe3e80c0b234c2
Autor:
Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M. Laudier, Venetia Zachariou, James C. Iatridis
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3425 (2023)
Intervertebral disc (IVD) degeneration with Modic-like changes is strongly associated with pain. Lack of effective disease-modifying treatments for IVDs with endplate (EP) defects means there is a need for an animal model to improve understanding of
Externí odkaz:
https://doaj.org/article/e3bdd6b53a2041dca2901cacd237f033
Autor:
Divya Krishnamoorthy, Robert C. Hoy, Devorah M. Natelson, Olivia M. Torre, Damien M. Laudier, James C. Iatridis, Svenja Illien-Jünger
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structure-mo
Externí odkaz:
https://doaj.org/article/c0b99b40da8241b3acb5ad2e352222ae
Autor:
Dalin Wang, Alon Lai, Jennifer Gansau, Alan C. Seifert, Jazz Munitz, Kashaf Zaheer, Neharika Bhadouria, Yunsoo Lee, Philip Nasser, Damien M. Laudier, Nilsson Holguin, Andrew C. Hecht, James C. Iatridis
BACKGROUND CONTEXT: Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better understand pathop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898f51172a42b916c06588adc5c1d676
https://doi.org/10.1101/2023.01.27.525924
https://doi.org/10.1101/2023.01.27.525924
Autor:
Kristen L. Howell, Matthias A. Zumstein, Helen L. Moser, Adam C. Abraham, Alice H. Huang, Leesa M. Galatz, Damien M. Laudier
Publikováno v:
J Orthop Res
Rotator cuff supraspinatus tendon injuries are common with high rates of anatomic failure after surgical repair. The purpose of the study was to define clinically relevant features of a mouse model of supraspinatus tendon injury to determine painful,
Autor:
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Publikováno v:
Biomaterials. 287
Discectomy procedures alleviate disability caused by intervertebral disc (IVD) herniation, but do not repair herniation-induced annulus fibrosus (AF) defects. Cell therapy shows promise for IVD repair, yet cell delivery biomaterials capable of sealin
Autor:
Dalin Wang, Alon Lai, Jennifer Gansau, Philip Nasser, Yunsoo Lee, Damien M. Laudier, James C. Iatridis
Publikováno v:
J Mech Behav Biomed Mater
Back pain is often associated with intervertebral disc (IVD) degeneration, and IVD degeneration phenotypes are commonly characterized by annulus fibrosus (AF)-driven and endplate (EP)-driven phenotypes. Few studies of EP injury exist in animal models
Autor:
Deepak Vashishth, Svenja Illien-Jünger, Philip Nasser, Devorah M. Natelson, Damien M. Laudier, Alon Lai, Jashvant Poeran, Divya Krishnamoorthy, Andrew Torres, Robert C. Hoy, Danielle N. D'Erminio, James C. Iatridis
Publikováno v:
J Orthop Res
Back pain and spinal pathologies are associated with obesity in juveniles and adults, yet studies identifying causal relationships are lacking and none investigate sex differences. This study determined if high fat (HF) diet causes structural and fun
Autor:
Victoria Mroz, Changli Zhang, Elizabeth W. Bradley, George Zhou, Olivia M. Torre, Alon Lai, Svenja Illien-Jünger, Robert C Hoy, James C. Iatridis, Madeline P. Smith, Jennifer J. Westendorf, Damien M. Laudier
Publikováno v:
Cell Death and Disease, Vol 10, Iss 10, Pp 1-15 (2019)
Cell Death & Disease
Cell Death & Disease
Back pain is a leading cause of global disability and is strongly associated with intervertebral disc (IVD) degeneration (IDD). Hallmarks of IDD include progressive cell loss and matrix degradation. The Akt signaling pathway regulates cellularity and