Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Damien M. Cronier"'
Autor:
Victor M. Villalobos, Gary Mo, Mark Agulnik, Seth M. Pollack, Daniel A. Rushing, Arun Singh, Brian A. Van Tine, Rhian McNaughton, Rodney L. Decker, Wei Zhang, Ashwin Shahir, Damien M. Cronier
Publikováno v:
Cancer Medicine, Vol 9, Iss 3, Pp 882-893 (2020)
Abstract Background Olaratumab, a fully human monoclonal antibody, selectively binds to human platelet‐derived growth factor receptor alpha and blocks ligand binding. This study assessed the effect of olaratumab on the pharmacokinetics (PK) of doxo
Externí odkaz:
https://doaj.org/article/ea5713e478994fba9c19d01324de61f2
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
PDF - 1128K, Figure S1. Knockdown of CDK7 and CDK9 can inhibit RNAP II CTD P-Ser2 and P-Ser5. Figure S2. LY2857785 and flavopiridol inhibit MCL-1, XIAP protein expression and induce CASP-3 and cleaved PARP in AML cell MV-4-11. Table S1. LY2857785 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb62eb48bfbf19159c380c73cb9da0d
https://doi.org/10.1158/1535-7163.22500105.v1
https://doi.org/10.1158/1535-7163.22500105.v1
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
XLSX - 54K, Table S2. 261 probsets gene signature in sens and res cell lines in Excel format.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70fa29c964bb208bbfee904a5d0548e
https://doi.org/10.1158/1535-7163.22500102
https://doi.org/10.1158/1535-7163.22500102
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805b19504f4ca7d3dd3ca23723e6c77
https://doi.org/10.1158/1535-7163.c.6536355
https://doi.org/10.1158/1535-7163.c.6536355
Autor:
Geoffrey I. Shapiro, Patrick Y. Wen, Keith T. Flaherty, Edward M. Chan, Damien M. Cronier, Martin Frenzel, Lily Q. Li, Palaniappan Kulanthaivel, Ricardo Martinez, Tuan S. Nguyen, Angie D. Fulford, Andrew E. Schade, Richard P. Beckmann, Aejaz Nasir, John F. Hilton, Drew W. Rasco, Muralidhar Beeram, Kyriakos P. Papadopoulos, Leena Gandhi, Jonathan W. Goldman, Anthony W. Tolcher, Sara M. Tolaney, Lee S. Rosen, Amita Patnaik
Supplementary Table 1. Summary of 33 Patients Treated with Abemaciclib in Dose Escalation. Supplementary Table 2. Baseline patient and disease characteristics. Supplementary Table 3. Possibly related treatment-emergent adverse events (>10% all grades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36991b4fd4f6f7c7f083e22b6e2c0a5d
https://doi.org/10.1158/2159-8290.22531521
https://doi.org/10.1158/2159-8290.22531521
Autor:
Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, Andres Forero-Torres
PDF file - 69K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5bce7434c575177dc299c654e0ecb9
https://doi.org/10.1158/1078-0432.22443729.v1
https://doi.org/10.1158/1078-0432.22443729.v1
Autor:
Kenneth C. Anderson, James E. Wooldridge, Damien M. Cronier, Christopher J. Kaiser, Ilaria Conti, Tuan S. Nguyen, Susan Carpenter, Andres Forero, Adam D. Cohen, Raymond J. Hohl, Gary Schiller, Paul G. Richardson, Edward A. Faber, Noopur S. Raje
Percentage Change from Baseline (PCB) for B-cells (CD19+) and Immunoglobulins (Ig)at 20-day time intervals post-baseline.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387a9ef6f5fd7dffebd49e21182e0fa0
https://doi.org/10.1158/1078-0432.22467221
https://doi.org/10.1158/1078-0432.22467221
Autor:
Kenneth C. Anderson, James E. Wooldridge, Damien M. Cronier, Christopher J. Kaiser, Ilaria Conti, Tuan S. Nguyen, Susan Carpenter, Andres Forero, Adam D. Cohen, Raymond J. Hohl, Gary Schiller, Paul G. Richardson, Edward A. Faber, Noopur S. Raje
Percentage Change from Baseline (PCB) for B-cells (CD19+) and Immunoglobulins (Ig)at 20-day time intervals post-baseline.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1083f3e87dcfda390895a523a9332083
https://doi.org/10.1158/1078-0432.22467218.v1
https://doi.org/10.1158/1078-0432.22467218.v1
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 247KB, Model simulations of the plasma concentration, the biomarker levels of p-Rb, TopoIIalpha and pHH3, and the effect parameters driving tumor growth inhibition for a 21 day daily dosing regimen of 25 (red line), 50 (blue line) and 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b5db9af7e29850dcb2c11a77a6b18
https://doi.org/10.1158/1078-0432.22446507
https://doi.org/10.1158/1078-0432.22446507
Autor:
Kristen N. Ganjoo, James E. Wooldridge, Brian K. Link, Mitchell R. Smith, Christopher A. Slapak, James G. Nelson, Barrett W. Allan, Susan P. Carpenter, Nam H. Dang, Damien M. Cronier, Maksim Pashkevich, Brad L. Pohlman, Sven de Vos, Andres Forero-Torres
PDF file - 122K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253351cf56a63c221795dc17528edcd9
https://doi.org/10.1158/1078-0432.22443726.v1
https://doi.org/10.1158/1078-0432.22443726.v1