Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Damien M Rasmussen"'
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Autor:
Damien M. Rasmussen, Manny M. Semonis, Joseph M. Muretta, Andrew R. Thompson, David D. Thomas, William C.K. Pomerantz, Nicholas M. Levinson
Publikováno v:
bioRxiv
Both first-generation αC-out and newer αC-in RAF inhibitors paradoxically activate BRAF kinase at subsaturating concentrations. Paradoxical activation by αC-in inhibitors is linked to the formation of BRAF dimers, but why activation rather than in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be22b6affe409fae8cfbcfc0f229d60
https://doi.org/10.1101/2023.04.18.536450
https://doi.org/10.1101/2023.04.18.536450
Autor:
Abir Majumdar, Gianluigi Veglia, Andrew R. Thompson, Tiffany A. Engel, Manu Veliparambil Subrahmanian, Nicholas M. Levinson, David D. Thomas, Joseph M. Muretta, David J. Burban, Damien M. Rasmussen
Publikováno v:
Nature chemical biology
Cyclin-dependent kinases (CDKs) are the master regulators of the eukaryotic cell cycle. To become activated, CDKs require both regulatory phosphorylation and binding of a cognate cyclin subunit. We studied the activation process of the G1/S kinase Cd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718f99a0223b2986545629535aa25c49
https://pubmed.ncbi.nlm.nih.gov/33526892
https://pubmed.ncbi.nlm.nih.gov/33526892
Autor:
Abir Majumdar, Damien M. Rasmussen, Erik B. Faber, Andrew R. Thompson, David D. Thomas, Joseph M. Muretta, Emily F. Ruff, Nicholas M. Levinson, Eric W. Lake
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Many drugs trigger changes to the structure of their target receptor upon binding. These conformational effects are thought to be an essential part of molecular recognition but have proven challenging to quantify. Using a high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7e838b277600ebbd4a0d0e15f08a2e
https://doi.org/10.1073/pnas.1811158115
https://doi.org/10.1073/pnas.1811158115