Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Damien Garbett"'
Autor:
Damien Garbett, Anjali Bisaria, Changsong Yang, Dannielle G. McCarthy, Arnold Hayer, W. E. Moerner, Tatyana M. Svitkina, Tobias Meyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extra
Externí odkaz:
https://doaj.org/article/59bc2c586f4e4738a09ac0f4b0640fca
Publikováno v:
Proceedings of the National Academy of Sciences. 119
To orchestrate cell mechanics, trafficking, and motility, cytoskeletal filaments must assemble into higher-order networks whose local subcellular architecture and composition specify their functions. Cross-linking proteins bridge filaments at the nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384eb6d5b9b66fc5d9acc309e41658ac
https://doi.org/10.1073/pnas.2205370119
https://doi.org/10.1073/pnas.2205370119
Autor:
Tobias Meyer, Anjali Bisaria, Damien Garbett, Changsong Yang, W. E. Moerner, Dannielle G. McCarthy, Tatyana Svitkina, Arnold Hayer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10b45c180180d1b94c19d340caa064c
http://link.springer.com/article/10.1038/s41467-020-18586-3
http://link.springer.com/article/10.1038/s41467-020-18586-3
To fulfill the cytoskeleton’s diverse functions in cell mechanics and motility, actin networks with specialized architectures are built by crosslinking proteins, which bridge filaments to control micron-scale network geometry through nanoscale bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f59dc6c8d5e02b317f1b3f37ce41ff4
https://doi.org/10.1101/2021.12.07.471696
https://doi.org/10.1101/2021.12.07.471696
Autor:
Sungmin Nam, Ovijit Chaudhuri, Ze Gong, Jay C. Hou, Damien Garbett, Katrina M. Wisdom, Tobias Meyer, Hong-pyo Lee, David J. Odde, Vivek B. Shenoy, Kolade Adebowale
Publikováno v:
Nat Mater
Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the leading edge, mature focal adhesions and spread morphologies. These observations result from adherent cell migration studies on stiff, elastic substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcb6e3142c0b509ab6044fd1958a97d
Autor:
Michael Rape, Kevin G. Mark, Lindsey R. Pack, Tobias Meyer, Damien Garbett, Steven D. Cappell
Publikováno v:
Nature. 558:313-317
Mammalian cells integrate mitogen and stress signalling before the end of G1 phase to determine whether or not they enter the cell cycle1–4. Before cells can replicate their DNA in S phase, they have to activate cyclin-dependent kinases (CDKs), ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2497095bcf45144e1cb9339c00510bb
https://doi.org/10.1038/s41586-018-0199-7
https://doi.org/10.1038/s41586-018-0199-7
Publikováno v:
Science
Actin cortex controls cell migration Cell migration is mainly controlled by local actin polymerization–driven membrane protrusion. However, a second structural mechanism might also regulate membrane protrusions and directed migration: changes in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d781fe0d76ffb2f7a522378305ab1abd
Publikováno v:
Molecular Biology of the Cell
The apical scaffolding protein E3KARP, a paralogue of EBP50, is regulated by Ser-303 cell-cycle phosphorylation. This phosphorylation enhances its exchange rate in vivo and reduces its apical localization and function. The dynamics of EBP50 and E3KAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2313a21254092f6884aaeda8c21c77
https://doi.org/10.1091/mbc.e15-07-0498
https://doi.org/10.1091/mbc.e15-07-0498
Autor:
Steven D, Cappell, Kevin G, Mark, Damien, Garbett, Lindsey R, Pack, Michael, Rape, Tobias, Meyer
Publikováno v:
Nature. 558(7709)
Mammalian cells integrate mitogen and stress signaling prior to the end of G1 phase to decide whether or not to enter the cell cycle1–4. Before cells can replicate their DNA in S phase, they have to activate cyclin-dependent kinases (CDKs), induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::982bf7875f7fe9c5f2f75b3773fa1c97
https://pubmed.ncbi.nlm.nih.gov/29875408
https://pubmed.ncbi.nlm.nih.gov/29875408
Autor:
Anthony Bretscher, Damien Garbett
Publikováno v:
Molecular Biology of the Cell
The function of scaffolding proteins is to bring together two or more proteins in a relatively stable configuration, hence their name. Numerous scaffolding proteins are found in nature, many having multiple protein–protein interaction modules. Over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878b7727f84332da7341821f2ad55a24
http://europepmc.org/articles/PMC4142605
http://europepmc.org/articles/PMC4142605