Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Damien Fraysse"'
Autor:
Clare M. Bolton, Peter Weber, Peter Chiu, Julie Jones, Damien Fraysse, Jimenez Juan Miguel, Elisabeth Doyle, Matthias Hesse, Adam P. Curnock
Publikováno v:
Biochemical Society Transactions. 42:1524-1528
Protein kinase Cθ (PKCθ) is a member of a large family of serine/threonine kinases that are involved in diverse cellular functions. PKCθ has roles in T-cell activation and survival, where the dependency of T-cell responses on this enzyme appears t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc85e7844e312be66337a013a4e898e
https://doi.org/10.1042/bst20140167
https://doi.org/10.1042/bst20140167
Autor:
John Pollard, Francesca Mazzei, Chau Mak, Damien Fraysse, Sanjay Patel, Sharn Ramaya, David Bebbington, John Studley, Joanne Pinder, Ronald Knegtel, Daniel Robinson, Andrew Miller, Francoise Pierard, Michael O'donnell, Alistair Rutherford, Jean-Damien Charrier, David Kay, Michael Mortimore, Simon Everitt, Hayley Binch, Golec Julian M C, James Westcott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3586-3592
The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925b30e50e9b61648460b5b023cd8ac
https://doi.org/10.1016/j.bmcl.2009.04.136
https://doi.org/10.1016/j.bmcl.2009.04.136
Autor:
Damien Fraysse, Peter Chiu, Philip N. Collier, Heather Twin, Luca Settimo, Francoise Pierard, Dean Boyall, Shazia Keily, Claire M. Bolton, Christopher John Davis, Guy Brenchley, Adam P. Curnock, Jaclyn Henderson, Adam Tanner, Juan-Miguel Jimenez, Andrew Miller, Stephen Clinton Young
Publikováno v:
Journal of medicinal chemistry. 56(5)
Protein kinase C θ (PKCθ) has a central role in T cell activation and survival; however, the dependency of T cell responses to the inhibition of this enzyme appears to be dictated by the nature of the antigen and by the inflammatory environment. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18d0371ff520503045d7d7722ddbc9b
https://pubmed.ncbi.nlm.nih.gov/23442161
https://pubmed.ncbi.nlm.nih.gov/23442161
Autor:
Ronald Knegtel, Ian Ager, Luca Settimo, Stephen Clinton Young, Dean Boyall, Richele K Rasmussen, Claire M. Bolton, Peter Chiu, Adam P. Curnock, Christopher John Davis, Adam Tanner, Juan-Miguel Jimenez, Damien Fraysse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
The identification of a novel series of PKCθ inhibitors and subsequent optimization using docking based on a crystal structure of PKCθ is described. SAR was rapidly generated around an amino pyridine-ketone hit; (6-aminopyridin-2-yl)(2-aminopyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcb8517f1186f9dfe4bbe54db055a35
https://pubmed.ncbi.nlm.nih.gov/22738630
https://pubmed.ncbi.nlm.nih.gov/22738630