Výsledky vyhledávání - "Damien Ficheux"

Akademický článek

Structuring detergents for extracting and stabilizing functional membrane proteins.

Autor: Rima Matar-Merheb, Moez Rhimi, Antoine Leydier, Frédéric Huché, Carmen Galián, Elodie Desuzinges-Mandon, Damien Ficheux, David Flot, Nushin Aghajari, Richard Kahn, Attilio Di Pietro, Jean-Michel Jault, Anthony W Coleman, Pierre Falson

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18036 (2011)

BACKGROUND: Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason is the fact that detergents do not stabilize membrane domains as efficiently as natural

Externí odkaz: https://doaj.org/article/d1116ef3cda343c380bc293ef9c8badf

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Akademický článek

Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptide.

Autor: Ammar Achour, Jean-Michel Biquard, Velibor Krsmanovic, Jean-Pierre M'bika, Damien Ficheux, Marianna Sikorska, Alain J Cozzone

Publikováno v: PLoS ONE, Vol 2, Iss 11, p e1214 (2007)

BackgroundCell mediated immunity, including efficient CTL response, is required to prevent HIV-1 from cell-to-cell transmission. In previous investigations, we have shown that B1 peptide derived by Fourier transformation of HIV-1 primary structures a

Externí odkaz: https://doaj.org/article/82aaafaf9e67463e915190b29ebc5b01

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'Reactive nanoprecipitation': a one-step route to functionalized polylactide-based nanoparticles

Autor: Damien Ficheux, Céline Terrat, Thomas Trimaille, Bernard Verrier, Didier Gigmes

Publikováno v: RSC Advances. 5:103060-103063

We report here a straightforward nanoprecipitation-based process to prepare functionalized polylactide (PLA) nanoparticles (NPs). It relies on an organic phase containing a PLA-based amphiphilic copolymer bearing N-succinimidyl esters that can sponta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78845affbd64b922b20f6f26a1da89d3
https://doi.org/10.1039/c5ra21578a

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Solid phase synthesis of the retro viral nucleocapsid protein NCp10 of Moloney Murine Leukaemia virus and related 'zinc-fingers' in free SH forms

Autor: Jean-Luc Darlix, Yves Mely, Marie-Claude Fournie-Zaluski, Isabelle Savignol, Dominique Gerard, Damien Ficheux, Bernard P. Roques, Fabrice Cornille

Publikováno v: International Journal of Peptide and Protein Research. 36:551-558

The core of retroviruses contains a highly conserved, low molecular weight, basic protein that binds nucleic acids and is essential for genomic RNA packaging. The 56 amino acid protein, NCp10, of Moloney Murine Leukaemia virus (MoMuLV) has the CysX2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4caeaecfda0b05584489d2f531bc3a7d
https://doi.org/10.1111/j.1399-3011.1990.tb00995.x

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Investigating the Mechanism of the Nucleocapsid Protein Chaperoning of the Second Strand Transfer during HIV-1 DNA Synthesis

Autor: Yves Mély, Hugues de Rocquigny, Jean-Luc Darlix, Damien Ficheux, Nick Ramalanjaona, Aurélie Millet

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2007, 374, pp.1041-1053
Journal of Molecular Biology, Elsevier, 2007, xxx, pp.1041-1053

International audience; Conversion of the human immunodeficiency virus type 1 (HIV-1) genomic RNA into the proviral DNA by reverse transcriptase involves two obligatory strand transfers that are chaperoned by the nucleocapsid protein (NC). The second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51433feedd35645be6cfd67bd3bf39d
https://doi.org/10.1016/j.jmb.2007.10.001

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Structural Requirements for Nucleocapsid Protein-mediated Dimerization of Avian Leukosis Virus RNA

Autor: Eric Ennifar, Philippe Fosse, Françoise Chaminade, Laurence Josset, Jean-Luc Darlix, Damien Ficheux, Igor Kanevsky, Moez Ben Ali

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2006, pp.1082-1096
Journal of Molecular Biology, Elsevier, 2006, pp.1082-1096. ⟨10.1016⟩
Journal of Molecular Biology, 2007, 372 (4), pp.1082-96. ⟨10.1016/j.jmb.2007.07.026⟩
Journal of Molecular Biology, Elsevier, 2007, 372 (4), pp.1082-96. ⟨10.1016/j.jmb.2007.07.026⟩

International audience; The avian leukosis virus (ALV) belongs to the alpha group of retroviruses that are widespread in nature. The 5'-untranslated region of ALV genome contains the L3 element that is important for virus infectivity and the formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43b87cb1cc0563473387ab68ff8be89
https://doi.org/10.1016/j.jmb.2007.07.026

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Analysis of hepatitis C virus RNA dimerization and core–RNA interactions

Autor: Igor Kanevsky, Philippe Fossé, Jean-Pierre Lavergne, Jean-Luc Darlix, François Penin, Caroline Gabus, Roland Ivanyi-Nagy, Damien Ficheux

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2006, 34 (9), pp.2618-33. ⟨10.1093/nar/gkl240⟩
Nucleic Acids Research, 2006, 34 (9), pp.2618-33. ⟨10.1093/nar/gkl240⟩

The core protein of hepatitis C virus (HCV) has been shown previously to act as a potent nucleic acid chaperone in vitro, promoting the dimerization of the 3'-untranslated region (3'-UTR) of the HCV genomic RNA, a process probably mediated by a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149c2d81b7b633649e287748bc7a5b21
http://europepmc.org/articles/PMC1463901

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During the Early Phase of HIV-1 DNA Synthesis, Nucleocapsid Protein Directs Hybridization of the TAR Complementary Sequences via the Ends of their Double-stranded Stem

Autor: Chinnappan Raja, Nicole Glasser, Hugues de Rocquigny, Jean-Luc Darlix, Damien Ficheux, Julien Godet, Yves Mély

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2006, 356, pp.1180-1192

International audience; Reverse transcription of HIV-1 genomic RNA requires two obligatory strand transfers. During the first strand transfer reaction, the minus strand strong-stop DNA (ss-cDNA) is transferred by hybridization of complementary sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1fcd416efd5c10b03e811592f0231f
https://doi.org/10.1016/j.jmb.2005.12.038

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Structure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A

Autor: Roland Montserret, Ralf Bartenschlager, Damien Ficheux, Darius Moradpour, Nicole Appel, Stephanie Ramboarina, François Penin, Hubert E. Blum, Volker Brass

Publikováno v: Journal of Biological Chemistry. 279:40835-40843

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a membrane-associated, essential component of the viral replication complex. Here, we report the three-dimensional structure of the membrane anchor domain of NS5A as determined by NMR spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7e25ef4d8397fde8071402af7d4b1b
https://doi.org/10.1074/jbc.m404761200

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α-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily

Autor: David J.S. Hulmes, Audrey McAlinden, Damien Ficheux, David A.D. Parry, Linda J. Sandell, Thomasin A. Smith

Publikováno v: Journal of Biological Chemistry. 278:42200-42207

Alpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils. Such sequences are found at the N-terminal e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2488c78ac1a1984194f01b22befff1
https://doi.org/10.1074/jbc.m302429200

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