Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Damien Ferraro"'
Autor:
Charles P. Hart, Mark D. Matteucci, John G. Curd, W. Steve Ammons, Jian-Xin Duan, Yan Wang, Damien Ferraro, Dharmendra Ahluwalia, Jingli Wang, Qian Liu, Jessica D. Sun
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fcaedba61d40db0e601de0a736eb65
https://doi.org/10.1158/1078-0432.22443263
https://doi.org/10.1158/1078-0432.22443263
Autor:
Yan Wang, Mark D. Matteucci, Qian Liu, Jessica D Sun, Dharmendra Ahluwalia, Don Jung, Charles P. Hart, Damien Ferraro
Publikováno v:
Cancer Biology & Therapy. 17:371-380
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide. In hypoxic conditions Br-IPM is released and alkylates DNA. Ifosfamide is a chloro-isophosphoramide prodrug activated by hepatic Cytochrome P450 enzymes. Bo
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Autor:
Yan Wang, Damien Ferraro, Dharmendra Ahluwalia, W. Steve Ammons, Mark D. Matteucci, Lee D. Cranmer, Jian Xin Duan, Jessica D Sun, John G. Curd, Charles P. Hart, Qian Liu, Amanda F. Baker, Jingli Wang
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:1487-1498
Subregional hypoxia is a common feature of tumors and is recognized as a limiting factor for the success of radiotherapy and chemotherapy. TH-302, a hypoxia-activated prodrug selectively targeting hypoxic regions of solid tumors, delivers a cytotoxic
Autor:
W. Steve Ammons, Damien Ferraro, Jingli Wang, Qian Liu, Yan Wang, Charles P. Hart, Dharmendra Ahluwalia, Jian-Xin Duan, John G. Curd, Mark D. Matteucci, Jessica D Sun
Publikováno v:
Clinical Cancer Research. 18:758-770
Purpose: Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). The
Autor:
Jess Bell, Stephen V. Liu, Damien Ferraro, Ronald L. Korn, Danny Rischin, Tillman E. Pearce, Jason Valardi
Publikováno v:
Journal of Clinical Oncology. 34:e23158-e23158
e23158Background: Tumor hypoxia is associated with resistance to chemotherapy and radiotherapy. Recurrent/metastatic squamous cell carcinomas of the head and neck & skin (SCCHN/SCCS) and non-small ...