Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Damien F Hudson"'
Autor:
Damien F Hudson, David J Amor, Amber Boys, Kathy Butler, Lorna Williams, Tao Zhang, Paul Kalitsis
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006483 (2016)
Bloom syndrome is a recessive human genetic disorder with features of genome instability, growth deficiency and predisposition to cancer. The only known causative gene is the BLM helicase that is a member of a protein complex along with topoisomerase
Externí odkaz:
https://doaj.org/article/13a2d069e43a41f2937e21354a20ca35
Autor:
Candice L Wike, Hillary K Graves, Reva Hawkins, Matthew D Gibson, Michelle B Ferdinand, Tao Zhang, Zhihong Chen, Damien F Hudson, Jennifer J Ottesen, Michael G Poirier, Jill Schumacher, Jessica K Tyler
Publikováno v:
eLife, Vol 5 (2016)
Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromos
Externí odkaz:
https://doaj.org/article/48487e7bf0d44c30afc1c804f5cab2f7
Autor:
Michelle C W Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, An Tran, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004964 (2015)
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can acc
Externí odkaz:
https://doaj.org/article/fbdbd16026c44294a31791d6aec3ee14
Publikováno v:
Seminars in Cell & Developmental Biology
Our understanding of the structure and function of mitotic chromosomes has come a long way since these iconic objects were first recognized more than 140 years ago, though many details remain to be elucidated. In this chapter, we start with the early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec025b30163980f574d31ed7547b8e23
https://doi.org/10.1016/j.semcdb.2021.03.014
https://doi.org/10.1016/j.semcdb.2021.03.014
Publikováno v:
Proc Natl Acad Sci U S A
Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensation. The primary roles of TOP2A in mitosis have been difficult to decipher due to its multiple functions across the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33b45f7f0834765b3ab6f573a05fb7d
https://pubmed.ncbi.nlm.nih.gov/32414923
https://pubmed.ncbi.nlm.nih.gov/32414923
Publikováno v:
The Journal of Cell Biology
Maeshima et al. preview work from the Walther et al. imaging Condensin behavior and describing its stoichiometry in mitosis to model chromosome condensation.
Condensins are key players in mitotic chromosome condensation. Using an elegant combina
Condensins are key players in mitotic chromosome condensation. Using an elegant combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66d1e34cdd3750f3731b569381be482
https://doi.org/10.1083/jcb.201804078
https://doi.org/10.1083/jcb.201804078
Publikováno v:
Open Biology, Vol 9, Iss 12 (2019)
Open Biology
Open Biology
Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e28467bf6d6ac0934ceeae54e9b340
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190222
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190222
Autor:
Paul, Kalitsis, Tao, Zhang, Ji Hun, Kim, Christian F, Nielsen, Kathryn M, Marshall, Damien F, Hudson
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2004
Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. Here, we highlight how to knock protein tags into endogenous loci to faithfully study the condensin complex in vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3abc07368f06e2c7474908530a28beb3
https://pubmed.ncbi.nlm.nih.gov/31147912
https://pubmed.ncbi.nlm.nih.gov/31147912
Publikováno v:
Cell Cycle. 15:3454-3470
The DNA damage checkpoint, when activated in response to genotoxic damage during S phase, arrests cells in G2 phase of the cell cycle. ATM, ATR, Chk1 and Chk2 kinases are the main effectors of this checkpoint pathway. The checkpoint kinases prevent t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d705a7e4305a392e295e023f43a8dc5
https://doi.org/10.1080/15384101.2016.1249075
https://doi.org/10.1080/15384101.2016.1249075
Autor:
Christian F. Nielsen, Paul Kalitsis, Tao Zhang, Ji Hun Kim, Kathryn M. Marshall, Damien F. Hudson
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995196
Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. Here, we highlight how to knock protein tags into endogenous loci to faithfully study the condensin complex in vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440e453903bdf6a1b58e7d792aac2f38
https://doi.org/10.1007/978-1-4939-9520-2_8
https://doi.org/10.1007/978-1-4939-9520-2_8
