Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Damien Demozay"'
Autor:
Sarah Hyllekvist Jørgensen, Kristina Bennet Emdal, Anna-Kathrine Pedersen, Lene Nygaard Axelsen, Helene Faustrup Kildegaard, Damien Demozay, Thomas Åskov Pedersen, Mads Grønborg, Rita Slaaby, Peter Kresten Nielsen, Jesper Velgaard Olsen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Insulin resistance impairs the cellular insulin response, and often precedes metabolic disorders, like type 2 diabetes, impacting an increasing number of people globally. Understanding the molecular mechanisms in hepatic insulin resistance i
Externí odkaz:
https://doaj.org/article/78e6b6a506d841aca705b82fea36c55f
Autor:
Vivi F H Jensen, Anne-Marie Mølck, Jette Nowak, Maria Wohlfarth, Eva Nüsken, Damien Demozay, Kai-Dietrich Nüsken, Ingrid B Bøgh
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265988 (2022)
Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutri
Externí odkaz:
https://doaj.org/article/9a0a516057bc45e7af4128d5a8bdcacf
Autor:
Henning Hvid, Christian L. Brand, Tina Hummelshøj, Sanne Jensen, Stephan D. Bouman, Andrew Bowler, Bjarne R. Poulsen, Peter Tiainen, Thorbjörn Åkertröm, Damien Demozay, Thomas Hoeg-Jensen, Camilla Ingvorsen, Thomas Å. Pedersen, Jim McGuire, Thomas Egebjerg, Karen A. Cappelen, Ina P. Eliasen, Bo F. Hansen, Stephanie Hennen, Carsten E. Stidsen, Grith S. Olsen, Nikolaj K. Roed
Publikováno v:
Diabetologia. 66(2)
Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of severe hypoglycaemia with intensive insulin therapy is a major obstacle that prevents many in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a9f61c32ff3fc5f78040483b515db
https://pubmed.ncbi.nlm.nih.gov/36404376
https://pubmed.ncbi.nlm.nih.gov/36404376
Autor:
CHRISTIAN FLEDELIUS, HELLE IVERSEN, RIKKE S. INGVORSEN, LISBETH B. ERIKSEN, ANNA BLOIS, YVENET MONTAUBAN, RENE RIJNBRAND, WEN HAN, JACOB F. JEPPESEN, DAMIEN DEMOZAY
Publikováno v:
Diabetes. 71
Insulin resistant individuals display elevated fasting and post-prandial glucose levels which are mainly driven by inadequate inhibition of gluconeogenesis (GNG) and are rarely normalized. The aim of this study was to investigate whether direct inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46368123f0ad423fe26b32e0ae16e125
https://doi.org/10.2337/db22-215-lb
https://doi.org/10.2337/db22-215-lb
Autor:
Brandon B. Boland, Christopher J. Rhodes, Joseph Grimsby, Damien Demozay, Cristina Alarcon, Charles Brown
Publikováno v:
Endocrinology. 159(2)
Mammalian metabolism has evolved to adapt to changes in nutrient status. Insulin, the key anabolic hormone, facilitates intracellular storage of nutrient fuels and plays a pivotal role in the transition away from catabolism upon refeeding. Although c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434a911c68d119e976b1975eb2058d05
https://pubmed.ncbi.nlm.nih.gov/29244064
https://pubmed.ncbi.nlm.nih.gov/29244064
Autor:
Mei Li, Amy J. Wright, Mark A. Atkinson, Brigid Gregg, Patrick C. Moore, Ben A. Hall, Damien Demozay, Christopher J. Rhodes, Aliya N. Husain
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:3197-3206
Insulin resistance can be compensated by increased functional pancreatic β-cell mass; otherwise, diabetes ensues. Such compensation depends not only on environmental and genetic factors but also on the baseline β-cell mass from which the expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5387fb36d4a56f31849340ae2a1e8
https://doi.org/10.1210/jc.2012-1206
https://doi.org/10.1210/jc.2012-1206
Autor:
Christopher J. Rhodes, Shin Tsunekawa, Isabelle Briaud, Roland Stein, Damien Demozay, Jill F. McCuaig, Domenico Accili
Publikováno v:
Diabetes
OBJECTIVE Appropriate regulation of insulin receptor substrate 2 (IRS-2) expression in pancreatic β-cells is essential to adequately compensate for insulin resistance. In liver, basal IRS-2 expression is controlled via a temporal negative feedback o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e3570bad2e166cd028a8ab377adb48
https://doi.org/10.2337/db11-0340
https://doi.org/10.2337/db11-0340
Publikováno v:
Diabetes
OBJECTIVE Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet β-cells by promoting growth and survival. IRS-2 turnover is rapid in primary β-cells, but its expression is highly regulated at the transcriptional level, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc487d310d81191bdcaa20dde1bc3fe
https://pubmed.ncbi.nlm.nih.gov/21940781
https://pubmed.ncbi.nlm.nih.gov/21940781
Publikováno v:
Diabetes. 57(5)
OBJECTIVE— Oxidative stress is associated with insulin resistance and is thought to contribute to progression toward type 2 diabetes. Oxidation induces cellular damages through increased amounts of reactive aldehydes from lipid peroxidation. The ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba49f0e9047b47b3ec3e7c15acb5d8a
https://pubmed.ncbi.nlm.nih.gov/18174527
https://pubmed.ncbi.nlm.nih.gov/18174527
Autor:
Emmanuel Van Obberghen, Damien Demozay, Sophie Grillo, Jean-Christophe Mas, Luciano Pirola, Carine Chavey, Stéphane Rocchi
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6261-6270. ⟨10.1074/jbc.M312062200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (8), pp.6261-6270. ⟨10.1074/jbc.M312062200⟩
Phosphatidylinositol 3-kinase signaling regulates the expression of several genes involved in lipid and glucose homeostasis; deregulation of these genes may contribute to insulin resistance and progression toward type 2 diabetes. By employing RNA arb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6eed6d6236d801f39c71fa75772349
https://hal.archives-ouvertes.fr/hal-03066275
https://hal.archives-ouvertes.fr/hal-03066275
