Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Damien Begue"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v
Externí odkaz:
https://doaj.org/article/d64305878b7f4abe9dd92a3040e7b4f4
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
Publikováno v:
eLife, Vol 8 (2019)
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz:
https://doaj.org/article/2f4c85fb4b8e4572b5af26dcb106d8f3
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2e8d59f2b3487af480f725db360e69
https://doi.org/10.1101/2023.02.08.527642
https://doi.org/10.1101/2023.02.08.527642
Autor:
Ulrike Naumann, David A. Ruddy, Debora Bonenfant, Valentina Cordo, Stephane Ferretti, Andreas Weiss, Verena Apfel, Ines Barbosa, Alexandra Buhles, Reinaldo Almeida, Grainne Kerr, Damien Begue, Laetitia Martinuzzi, Giorgio G. Galli, Luca Tordella, Michelle Piquet, Laura Holzer
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4617fa9d1331f299416bc9bfec2b576
https://doi.org/10.1021/acsptsci.0c00196
https://doi.org/10.1021/acsptsci.0c00196
The problematic connection between low-luminosity gamma-ray bursts and ultra-high-energy cosmic rays
Publikováno v:
Proceedings of 37th International Cosmic Ray Conference — PoS(ICRC2021).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6046a7304b7959962b2370f97c263b
https://doi.org/10.22323/1.395.0467
https://doi.org/10.22323/1.395.0467
Autor:
Feng Cong, Bo Lu, Damien Begue, Youzhen Wang, Mika Manser, Alicia Lindeman, John S. Reece-Hoyes, Qiong Wang, Hao Zeng, Xiaomo Jiang, Debora Bonenfant, Carsten Russ, Raffaella Zamponi, Shumei Qiu, Johnny Castillo-Cabrera, Frederic Sigoillot, Vaik Strande, Zinger Yang
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61abbde7cb9e64212a50ddcb52a3dfb
https://doi.org/10.7554/elife.50223
https://doi.org/10.7554/elife.50223
Autor:
Johnny Castillo-Cabrera, Alicia Lindeman, Xiaomo Jiang, Carsten Russ, Frederic Sigoillot, Debora Bonenfant, Damien Begue, Shumei Qiu, Raffaella Zamponi, Feng Cong, Hao Zeng, Mika Manser, Bo Lu, Youzhen Wang, Qiong Wang, Vaik Strande, Zinger Yang, John S. Reece-Hoyes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40e3295e80b4df6685068ff933d82852
https://doi.org/10.7554/elife.50223.sa2
https://doi.org/10.7554/elife.50223.sa2