Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Damien Abreu"'
Autor:
Damien Abreu, Stephen I. Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, Cris M. Brown, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess A. Marshall, Tamara Hershey, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and roden
Externí odkaz:
https://doaj.org/article/cc59812ac3294482ac751139a8922e28
Autor:
Amy L. Clark, Kohsuke Kanekura, Zeno Lavagnino, Larry D. Spears, Damien Abreu, Jana Mahadevan, Takuya Yagi, Clay F. Semenkovich, David W. Piston, Fumihiko Urano
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cy
Externí odkaz:
https://doaj.org/article/be8e2bac311c4815b5a158b712b3a6a3
Autor:
Brian S. Kim, Damien Abreu
Publikováno v:
Immunology and Allergy Clinics of North America. 41:347-359
Dermatitis encompasses a spectrum of inflammatory skin disorders with aberrant immune responses classified as type 1, type 2, and/or type 3. Major advances in the understanding of the pathogenesis of atopic dermatitis (AD) have shed new light on how
Autor:
Takuya Yagi, Cris M. Brown, Simin Lu, Fumihiko Urano, Jana Mahadevan, Damien Abreu, Kohsuke Kanekura, Shuntaro Morikawa
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Endoplasmic reticulum (ER) stress-mediated cell death is an emerging target for human chronic disorders, including neurodegeneration and diabetes. However, there is currently no treatment for preventing ER stress-mediated cell death. Here, we show th
Autor:
Fumihiko Urano, Michael R. DiGruccio, David W. Piston, Jung Hoon Cho, Xue Wen Ng, Damien Abreu, Hannah Conway, Henry F. Roseman, Jing W. Hughes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The primary cilium is a small subcompartment of the cell but has powerful influence on pancreatic islet function. In this study, we find a critical role for cilia in regulating β-cell function and energy metabolism. Importantly, the del
Autor:
David W. Piston, Fumihiko Urano, John M P Revilla, Kelly Kries, Rie Asada, Damien Abreu, Zeno Lavagnino
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and apoptosis. The mechanisms guiding β-cell outcomes secondary to WFS1 function, however
Autor:
Ashley N Simpson, Damien Abreu, Toni S. Pearson, Hongjie Gu, Tamara Hershey, Neil H. White, Gregory P. Van Stavern, James Hoekel, Stacy Hurst, Robert C. Bucelli, Chinyere Onwumere, Cris M. Brown, Bess A. Marshall, Stephen I. Stone, Fumihiko Urano, Kelly Kries, Lawrence Tychsen
Publikováno v:
JCI Insight.
BACKGROUNDWolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and rodent
Autor:
Rolf Graf, Jana Mahadevan, Rie Asada, Bess A. Marshall, Stephen I. Stone, Kelly Kries, Damien Abreu, Fumihiko Urano, Tamara Hershey
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 and type 2 diabetes mellitus, as well as genetic forms of diabetes, especially Wolfram syndrome. However, there are currently no convenient ways to as
Autor:
Damien, Abreu, Stephen I, Stone, Toni S, Pearson, Robert C, Bucelli, Ashley N, Simpson, Stacy, Hurst, Cris M, Brown, Kelly, Kries, Chinyere, Onwumere, Hongjie, Gu, James, Hoekel, Lawrence, Tychsen, Gregory P, Van Stavern, Neil H, White, Bess A, Marshall, Tamara, Hershey, Fumihiko, Urano
Publikováno v:
JCI Insight
BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and roden
Autor:
Neil H. White, Toni S. Pearson, Stacy Hurst, Hongjie Gu, Tamara Hershey, Ashley N Simpson, Lawrence Tychsen, Cris M. Brown, Kelly Kries, James Hoekel, Damien Abreu, Bess A. Marshall, Stephen I. Stone, Fumihiko Urano, Robert C. Bucelli, Gregory P. Van Stavern
BackgroundWolfram syndrome is a rare endoplasmic reticulum disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is currently no treatment to delay, halt, or reverse the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb70672123fe31e0eed6b81fc5615a0f
https://doi.org/10.1101/2020.10.07.20208694
https://doi.org/10.1101/2020.10.07.20208694