Deep learning improves macromolecule identification in 3D cellular cryo-electron tomograms

Autor: Sahradha Albert, Ricardo D. Righetto, Emmanuel Moebel, Charles Kervrann, Tingying Peng, Antonio Martinez-Sanchez, Julio O. Ortiz, Wojciech Wietrzynski, Stefan Pfeffer, Lorenz Lamm, Damien Larivière, Benjamin D. Engel, Wolfgang Baumeister, Eric Fourmentin

Publikováno v: Nature Methods
Nature Methods, 2021, 18 (11), pp.1386-1394. ⟨10.1038/s41592-021-01275-4⟩
Nature Methods, Nature Publishing Group, 2021, 18 (11), pp.1386-1394. ⟨10.1038/s41592-021-01275-4⟩
Nature methods 18(11), 1386-1394 (2021). doi:10.1038/s41592-021-01275-4
Nat. Methods 18, 1386-1394 (2021)
BioImage Informatics 2021
BioImage Informatics 2021, Nov 2021, Paris, France. pp.1-43
BioImage Informatics 2021 (selected talk)
BioImage Informatics 2021 (selected talk), Nov 2021, Paris, France

Cryogenic electron tomography (cryo-ET) visualizes the 3D spatial distribution of macromolecules at nanometer resolution inside native cells. However, automated identification of macromolecules inside cellular tomograms is challenged by noise and rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa11ecb734146eafaab67196e1daef66
https://hdl.handle.net/21.11116/0000-0009-CAC0-A

Deep Learning Improves Macromolecule Identification in 3D Cellular Cryo-Electron Tomograms

Autor: Charles Kervrann, Sahradha Albert, Julio O. Ortiz, Ricardo D. Righetto, Wojciech Wietrzynski, Benjamin D. Engel, Stefan Pfeffer, Emmanuel Moebel, Tingying Peng, Antonio Martinez-Sanchez, Lorenz Lamm, Eric Fourmentin, Damien Larivière, Wolfgang Baumeister

Cryo-electron tomography (cryo-ET) visualizes the 3D spatial distribution of macromolecules at nanometer resolution inside native cells. While this label-free cryogenic imaging technology produces data containing rich structural information, automate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6df3c85b6d2fd0a8c98d7d4be0e7d208
https://doi.org/10.1101/2020.04.15.042747

Will biologists become computer scientists? A truly interdisciplinary effort by computer scientists and biologists to understand how cells process information may yield new insights for both fields

Autor: Tsvi Tlusty, Hélène Kirchner, Damien Larivière, Wallace F. Marshall, Anne Condon, Eric Fourmentin, Vincent Noireaux

Publikováno v: EMBO reports, vol 19, iss 9

EMBO Reports (2018) e46628 The idea that living systems could be understood and described as information‐processing systems has been around even before the first computers were built. From Alan Turing's considerable paper in 1936 to Erwin Schroding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ec57aca5384fd205b38dcd73418383
https://escholarship.org/uc/item/2cs2r86s

A User-Friendly DNA Modeling Software for the Interpretation of Cryo-Electron Microscopy Data

Autor: Bruno Levy, Eric Fourmentin, Jean-François Ménétret, Damien Larivière, Rodrigo Galindo-Murillo, Julie Papillon, Valérie Lamour, Samuel Hornus

Publikováno v: The Bacterial Nucleoid ISBN: 9781493970971

The structural modeling of a macromolecular machine is like a "Lego" approach that is challenged when blocks, like proteins imported from the Protein Data Bank, are to be assembled with an element adopting a serpentine shape, such as DNA templates. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce3d201759a44bff192e380beb433bdb
https://doi.org/10.1007/978-1-4939-7098-8_15

Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli

Autor: Roger J. Heinze, Annet Reumer, Titia K. Sixma, Andreas D Marx, Michele Cristóvão, Ute Curth, Ines Winkler, Peter Friedhoff, Damien Larivière

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry; Vol 286

The ternary complex comprising MutS, MutL, and DNA is a key intermediate in DNA mismatch repair. We used chemical cross-linking and fluorescence resonance energy transfer (FRET) to study the interaction between MutS and MutL and to shed light onto th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53bbbe160fb07f80d95356afa820aa5
https://pubmed.ncbi.nlm.nih.gov/21454657