The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells

Autor: Francesco Papa, Francesca Paola Lorusso, Anna Maria Sardanelli, Patrizio Panelli, Alessandro Stella, Damiano Panelli, Sergio Papa, Massimo Caputi

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1829:211-218

A study is presented on the regulation of alternative splicing (AS) of the Ndufb11 gene of complex I of the mitochondrial respiratory chain and the impact on this process of rotenone treatment in neuroblastoma cells. In physiological conditions the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6795b1a22c4729bccd54c34d7ce18f0
https://doi.org/10.1016/j.bbagrm.2012.12.001

Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases

Autor: Zuzana Technikova-Dobrova, Sergio Papa, Domenico De Rasmo, Vittoria Petruzzella, Damiano Panelli, Francesco Papa, Giuseppe Palmisano, Anna Maria Sardanelli, Anna Signorile, Antonio Gnoni, Salvatore Scacco, Loris Micelli

Publikováno v: Papa, S, De Rasmo, D, Technikova-Dobrova, Z, Panelli, D, Signorile, A, Scacco, S, Petruzzella, V, Papa, F, Palmisano, G, Gnoni, A, Micelli, L & Sardanelli, A M 2012, ' Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases ', F E B S Letters, vol. 586, no. 5, pp. 568-577 . https://doi.org/10.1016/j.febslet.2011.09.019

In mammals, complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain has 31 supernumerary subunits in addition to the 14 conserved from prokaryotes to humans. Multiplicity of structural protein components, as well as of bioge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e18ec26646a5ffbf1c6044ee5bfbcb
https://doi.org/10.1016/j.febslet.2011.09.019

Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases

Autor: Nazzareno Capitanio, M Scivetti, Giuseppe De Michele, Damiano Panelli, Claudia Piccoli, Teresa Rizza, Raffaella Trentadue, Arcangela Iuso, Francesco Papa, Domenico De Rasmo, Vittoria Petruzzella, Enrico Bertini, Salvatore Scacco, Anna Maria Sardanelli, Rita Vitale, Sergio Papa

Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787:502-517

This paper covers genetic and biochemical aspects of mitochondrial bioenergetics dysfunction in hereditary neurological disorders associated with complex I defects. Three types of hereditary complex I dysfunction are dealt with: (i) homozygous mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1bf6d7880b1cdf84814aa74a328ee8
https://doi.org/10.1016/j.bbabio.2008.12.018

Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms

Autor: Vittoria, Petruzzella, Anna Maria, Sardanelli, Salvatore, Scacco, Damiano, Panelli, Francesco, Papa, Raffaella, Trentadue, Sergio, Papa

Publikováno v: Advances in experimental medicine and biology. 942

This chapter covers genetic and biochemical aspects of mitochondrial bioenergetics dysfunction in neurological disorders associated with complex I defects. Complex I formation and functionality in mammalian cells depends on coordinated expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aee7decc17fb6af4354910f75106c15e
https://pubmed.ncbi.nlm.nih.gov/22399432

Dysfunction of Mitochondrial Respiratory Chain Complex I in Neurological Disorders: Genetics and Pathogenetic Mechanisms

Autor: Damiano Panelli, Sergio Papa, Raffaella Trentadue, Vittoria Petruzzella, Francesco Papa, Salvatore Scacco, Anna Maria Sardanelli

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9789400728684

This chapter covers genetic and biochemical aspects of mitochondrial bioenergetics dysfunction in neurological disorders associated with complex I defects. Complex I formation and functionality in mammalian cells depends on coordinated expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3015386108bc99206bfa698b4640bccf
https://doi.org/10.1007/978-94-007-2869-1_17