Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Damian Yap"'
Autor:
Peter Eirew, Ciara O’Flanagan, Jerome Ting, Sohrab Salehi, Jazmine Brimhall, Beixi Wang, Justina Biele, Teresa Algara, So Ra Lee, Corey Hoang, Damian Yap, Steven McKinney, Cherie Bates, Esther Kong, Daniel Lai, Sean Beatty, Mirela Andronescu, Elena Zaikova, Tyler Funnell, Nicholas Ceglia, Stephen Chia, Karen Gelmon, Colin Mar, Sohrab Shah, Andrew Roth, Alexandre Bouchard-Côté, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Gene fitness and essentiality analyses using in vivo cancer models are challenging due to multiple confounders. Here, the authors develop a quantitative approach to study CRISPR-transduced patient-derived xenografts, which they use to analyse in vivo
Externí odkaz:
https://doaj.org/article/5fd8470d7bc644e19c6718168d7a7669
Autor:
John Hilton, Karen Gelmon, Philippe L. Bedard, Dongsheng Tu, Hong Xu, Anna V. Tinker, Rachel Goodwin, Scott A. Laurie, Derek Jonker, Aaron R. Hansen, Zachary W. Veitch, Daniel J. Renouf, Linda Hagerman, Hongbo Lui, Bingshu Chen, Deb Kellar, Irene Li, Sung-Eun Lee, Takako Kono, Brian Y. C. Cheng, Damian Yap, Daniel Lai, Sean Beatty, John Soong, Kathleen I. Pritchard, Isabel Soria-Bretones, Eric Chen, Harriet Feilotter, Moira Rushton, Lesley Seymour, Samuel Aparicio, David W. Cescon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
G-quadruplex stabilizers, including CX-5461, exhibit synthetic lethality with loss of BRCA1/2 in preclinical models. Here the authors report the results of a phase I study of CX-5461 in patients with solid tumors enriched for DNA-repair deficiencies.
Externí odkaz:
https://doaj.org/article/ee095627571b4e258e1890f77d3d7597
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be
Externí odkaz:
https://doaj.org/article/5b722e62084b4032919682ab16257e1a
Autor:
Yemin Wang, Jiamin Chen, Winnie Yang, Fan Mo, Janine Senz, Damian Yap, Michael S. Anglesio, Blake Gilks, Gregg B. Morin, David G. Huntsman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 8, Pp 650-660 (2015)
DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of
Externí odkaz:
https://doaj.org/article/5bfac26fdb804067afaf5cac6418b5c2
Autor:
Kelvin Yeung, Ann Boija, Edvin Karlsson, Per-Henrik Holmqvist, Yonit Tsatskis, Ilaria Nisoli, Damian Yap, Alireza Lorzadeh, Michelle Moksa, Martin Hirst, Samuel Aparicio, Manolis Fanto, Per Stenberg, Mattias Mannervik, Helen McNeill
Publikováno v:
eLife, Vol 6 (2017)
Mutations in human Atrophin1, a transcriptional corepressor, cause dentatorubral-pallidoluysian atrophy, a neurodegenerative disease. Drosophila Atrophin (Atro) mutants display many phenotypes, including neurodegeneration, segmentation, patterning an
Externí odkaz:
https://doaj.org/article/0bd2f64c752349fd9c79d349b5cff0b5
Autor:
Robert Kridel, Fong Chun Chan, Anja Mottok, Merrill Boyle, Pedro Farinha, King Tan, Barbara Meissner, Ali Bashashati, Andrew McPherson, Andrew Roth, Karey Shumansky, Damian Yap, Susana Ben-Neriah, Jamie Rosner, Maia A Smith, Cydney Nielsen, Eva Giné, Adele Telenius, Daisuke Ennishi, Andrew Mungall, Richard Moore, Ryan D Morin, Nathalie A Johnson, Laurie H Sehn, Thomas Tousseyn, Ahmet Dogan, Joseph M Connors, David W Scott, Christian Steidl, Marco A Marra, Randy D Gascoyne, Sohrab P Shah
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002197 (2016)
BackgroundFollicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience an increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immuno
Externí odkaz:
https://doaj.org/article/cfa88ca4dd45448eacb1f85e9a67401d
Autor:
Haiyang Yun, Frederik Damm, Damian Yap, Adrian Schwarzer, Anuhar Chaturvedi, Nidhi Jyotsana, Michael Lübbert, Lars Bullinger, Konstanze Döhner, Robert Geffers, Samuel Aparicio, R. Keith Humphries, Arnold Ganser, Michael Heuser
Publikováno v:
Haematologica, Vol 99, Iss 9 (2014)
Hypomethylating agents are widely used in patients with myelodysplastic syndromes and unfit patients with acute myeloid leukemia. However, it is not well understood why only some patients respond to hypomethylating agents. We found previously that th
Externí odkaz:
https://doaj.org/article/c1c01bbebbe84a66b400432de44adc56
Autor:
Alexander Lemak, Adelinda Yee, Hong Wu, Damian Yap, Hong Zeng, Ludmila Dombrovski, Scott Houliston, Samuel Aparicio, Cheryl H Arrowsmith
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77020 (2013)
Mixed Lineage Leukemia 5 (MLL5) is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. In addition to its catalytic domain, MLL5 contains a PHD finger domain, a protein module that is often
Externí odkaz:
https://doaj.org/article/b06acf9d1d7d4120b22de65f3d883735
Autor:
Nicholas Ceglia, Diljot Grewal, Justina Biele, Weiner Ac, Brimhall J, Peter Eirew, Samuel Aparicio, Ciara H. O'Flanagan, Havasov E, Masud T, Hakwoo Lee, Beatty S, Samantha Leung, Florian Uhlitz, Abrams D, Ignacio Vázquez-García, Marc J Williams, Damian Yap, Daniel Lai, Salehi S, Sohrab P. Shah, Ting J, Wang B, Farhia Kabeer, Nicole Rusk, Bojilova, Tyler Funnell, Jenifer Pham, Andrew McPherson
Cancer genomes exhibit extensive chromosomal copy number changes and structural variation, yet how allele specific alterations drive cancer genome evolution remains unclear. Here, through application of a new computational approach we report allele s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfe906a55569752a1cc9c03c621e85ce
https://doi.org/10.1101/2021.06.04.447031
https://doi.org/10.1101/2021.06.04.447031