Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Damian W. Young"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract The thermal shift assay (TSA)—also known as differential scanning fluorimetry (DSF), thermofluor, and Tm shift—is one of the most popular biophysical screening techniques used in fragment-based ligand discovery (FBLD) to detect protein
Externí odkaz:
https://doaj.org/article/716f45629e2b4f94b161dcee7038bf05
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Seyed Arad Moghadasi, Morgan A. Esler, Yuka Otsuka, Jordan T. Becker, Sofia N. Moraes, Constance B. Anderson, Srinivas Chamakuri, Christopher Belica, Chloe Wick, Daniel A. Harki, Damian W. Young, Louis Scampavia, Timothy P. Spicer, Ke Shi, Hideki Aihara, William L. Brown, Reuben S. Harris
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The main protease, Mpro, of SARS-CoV-2 is required to cleave the viral polyprotein into precise functional units for virus replication and pathogenesis. Here, we report quantitative reporters for Mpro function in living cells in which protea
Externí odkaz:
https://doaj.org/article/5f8de00bdfcb488bbae8b0acf0272a23
Autor:
Alejandro Sarrion-Perdigones, Lyra Chang, Yezabel Gonzalez, Tatiana Gallego-Flores, Damian W. Young, Koen J. T. Venken
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Multiplexed detection of luciferase-based sensors in the same sample is challenging and limited by the substrates’ emission spectra. Here the authors establish a system based on three different luciferases and sequential detection to achieve measur
Externí odkaz:
https://doaj.org/article/d0eba81dab4c416f9ae7a95bfa426800
Autor:
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Molecules, Vol 27, Iss 11, p 3419 (2022)
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five
Externí odkaz:
https://doaj.org/article/e03a14a45cc14395a67b86b6084b9499
Autor:
Murugesan Palaniappan, Kurt M. Bohren, Yong Wang, Damian W. Young, Suzanne A. Fuqua, Martin M. Matzuk
Publikováno v:
Cancer Research. 83:P6-10
Background: Activating somatic ESR1 mutations Y537S and D538G occur more frequently in endocrine therapy-resistant metastatic breast cancer, which is associated with an aggressive phenotype and poor survival in breast cancer patients. These gain of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::444fe3e4b1fba73600a2be509c16b62a
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-12
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-12
Autor:
Ram K. Modukuri, Diana Monsivais, Feng Li, Murugesan Palaniappan, Kurt M. Bohren, Zhi Tan, Angela F. Ku, Yong Wang, Chandrashekhar Madasu, Jian-Yuan Li, Suni Tang, Gabriella Miklossy, Stephen S. Palmer, Damian W. Young, Martin M. Matzuk
Publikováno v:
Journal of Medicinal Chemistry. 66:2143-2160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899e0b4e19580a2aa29d02840b07db86
https://doi.org/10.1021/acs.jmedchem.2c01886
https://doi.org/10.1021/acs.jmedchem.2c01886
Autor:
Rihana S. Bokhari, Afshin Beheshti, Sarah E. Blutt, Dawn E. Bowles, David Brenner, Robert Britton, Lawrence Bronk, Xu Cao, Anushree Chatterjee, Delisa E. Clay, Colleen Courtney, Donald T. Fox, M.Waleed Gaber, Sharon Gerecht, Peter Grabham, David Grosshans, Fada Guan, Erin A. Jezuit, David G. Kirsch, Zhandong Liu, Mirjana Maletic-Savatic, Kyle M. Miller, Ruth A. Montague, Prashant Nagpal, Sivan Osenberg, Luke Parkitny, Niles A. Pierce, Christopher Porada, Susan M. Rosenberg, Paul Sargunas, Sadhana Sharma, Jamie Spangler, Daniel Naveed Tavakol, Dilip Thomas, Gordana Vunjak-Novakovic, Chunbo Wang, Luke Whitcomb, Damian W. Young, Dorit Donoviel
Publikováno v:
Life Sciences in Space Research. 35:105-112
Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db21af2f4810813483ee882f5aff2ef
https://doi.org/10.1016/j.lssr.2022.08.003
https://doi.org/10.1016/j.lssr.2022.08.003
Publikováno v:
Journal of Medicinal Chemistry. 65:14289-14304
A range of enzymes drive human physiology, and their activities are tightly regulated through numerous signaling pathways. Depending on the context, these pathways may activate or inhibit an enzyme as a way to ensure proper execution of cellular func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262c40ca8fe453e4b531680b12194d58
https://doi.org/10.1021/acs.jmedchem.2c01291
https://doi.org/10.1021/acs.jmedchem.2c01291