Cholinergic modulation of dentate gyrus processing through dynamic reconfiguration of inhibitory circuits

Autor: Mora B. Ogando, Olivia Pedroncini, Noel Federman, Sebastián A. Romano, Luciano A. Brum, Guillermo M. Lanuza, Damian Refojo, Antonia Marin-Burgin

Publikováno v: Cell Reports, Vol 36, Iss 8, Pp 109572- (2021)

Summary: The dentate gyrus (DG) of the hippocampus plays a key role in memory formation, and it is known to be modulated by septal projections. By performing electrophysiology and optogenetics, we evaluated the role of cholinergic modulation in the p

Externí odkaz: https://doaj.org/article/a6009a4d7f3643b3a402e38da29b7393

MicroRNA-9 controls dendritic development by targeting REST

Autor: Sebastian A Giusti, Annette M Vogl, Marisa M Brockmann, Claudia A Vercelli, Martin L Rein, Dietrich Trümbach, Wolfgang Wurst, Demian Cazalla, Valentin Stein, Jan M Deussing, Damian Refojo

Publikováno v: eLife, Vol 3 (2014)

MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitor

Externí odkaz: https://doaj.org/article/8d59cdbcf0d342a4a0ce2238b26225f7

Super-resolution Imaging of Energy Transfer by Intensity-Based STED-FRET

Autor: Alan M. Szalai, Thomas M. Jovin, Philip Tinnefeld, Nicolas Unsain, Bruno Siarry, Florian Steiner, Alfredo Cáceres, Fernando D. Stefani, Jerónimo Lukin, Damian Refojo, Sebastian A. Giusti

Publikováno v: Nano letters. 21(5)

Forster resonance energy transfer (FRET) imaging methods provide unique insight into the spatial distribution of energy transfer and (bio)molecular interaction events, though they deliver average information for an ensemble of events included in a di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e2032bc05146a53539b6f1839af2e
https://pubmed.ncbi.nlm.nih.gov/33621102

Automated quantification of protein periodic nanostructures in fluorescence nanoscopy images: abundance and regularity of neuronal spectrin membrane-associated skeleton

Autor: Damian Refojo, Federico Martín Barabas, Martín Diego Bordenave, Sebastian A. Giusti, Luciano A. Masullo, Fernando D. Stefani, Alfredo Cáceres, Nicolas Unsain

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Fluorescence nanoscopy imaging permits the observation of periodic supramolecular protein structures in their natural environment, as well as the unveiling of previously unknown protein periodic structures. Deciphering the biological functions of suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0a44efe3d581d228b1b97716c47503
http://link.springer.com/article/10.1038/s41598-017-16280-x

Neddylation regulates excitatory synaptic transmission and plasticity

Autor: Ulf Einsfelder, Marisa M Brockmann, Nils Körber, Valentin Stein, Damian Refojo, Michael Döngi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports

Post-translational modifications, like phosphorylation, ubiquitylation, and sumoylation, have been shown to impact on synaptic neurotransmission by modifying pre- and postsynaptic proteins and therefore alter protein stability, localization, or prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3137e28ca36c44e75ff02728d4a70
https://doi.org/10.1038/s41598-019-54182-2