Výsledky vyhledávání - "Damian M. Kraus"

Alternative Complement Pathway Activation Is Essential for Inflammation and Joint Destruction in the Passive Transfer Model of Collagen-Induced Arthritis

Autor: William P. Arend, Joshua M. Thurman, Damian M. Kraus, Allyson Wood, V. Michael Holers, Michael C. Carroll, Nirmal K. Banda

Publikováno v: The Journal of Immunology. 177:1904-1912

Activation of each complement initiation pathway (classical, alternative, and lectin) can lead to the generation of bioactive fragments with resulting inflammation in target organs. The objective of the current study was to determine the role of spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15fb663b6a37d495ceaf0a446cb30b5
https://doi.org/10.4049/jimmunol.177.3.1904

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CSMD1 Is a Novel Multiple Domain Complement-Regulatory Protein Highly Expressed in the Central Nervous System and Epithelial Tissues

Autor: Gary Elliott, Andrew A. Welcher, Hilary T. Chute, Sheila Scully, Damian M. Kraus, V. Michael Holers, Staci D. Sanford, Foster Stephen, Tom Horan, Karl H. Pfenninger

Publikováno v: The Journal of Immunology. 176:4419-4430

In this study, we describe the identification and in vitro functional activity of a novel multiple domain complement regulatory protein discovered based on its homology to short consensus repeat (SCR)-containing proteins of the regulators of compleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ed87174a134591141b63e1a0afaf07
https://doi.org/10.4049/jimmunol.176.7.4419

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Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion

Autor: Damian M. Kraus, Joshua M. Thurman, NP Barry, Moshe Levi, Hector Molina, Danica Galešić Ljubanović, V. Michael Holers, Pamela A. Royer, Gregory Proctor

Publikováno v: Journal of Clinical Investigation. 116:357-368

Ischemia/reperfusion (I/R) of several organs results in complement activation, but the kidney is unique in that activation after I/R occurs only via the alternative pathway. We hypothesized that selective activation of this pathway after renal I/R co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ebc6a6481b72a4f5b7b37cff4f50bb
https://doi.org/10.1172/jci24521

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A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice

Autor: Pamela A. Royer, Lynne M. Mitchell, Jane E. Salmon, Dennis E. Hourcade, Patricia C. Giclas, V. Michael Holers, Gary S. Gilkeson, Joshua M. Thurman, Guillermina Girardi, Damian M. Kraus, Hee J. Kang

Publikováno v: Molecular Immunology. 42:87-97

Studies in gene-targeted mice have demonstrated that factor B of the alternative complement pathway plays an important role in several disease models, but an exogenous inhibitor of factor B has not previously been available. We have developed an inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b57b9b3ac20284750bb16135abe933
https://doi.org/10.1016/j.molimm.2004.07.043

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Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y

Autor: Damian M. Kraus, Nirmal K. Banda, V. Michael Holers, Alison M. Bendele, William P. Arend, Michele Muggli

Publikováno v: The Journal of Immunology. 171:2109-2115

The objective of these studies was to examine collagen-induced arthritis (CIA) in C57BL/6 mice transgenic for the rodent complement regulatory protein complement receptor 1-related gene/protein y (Crry) (Crry-Tg), a C3 convertase inhibitor. The score

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404c9b53ac3e9f3199a5991738a32218
https://doi.org/10.4049/jimmunol.171.4.2109

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Administration of a Soluble Recombinant Complement C3 Inhibitor Protects Against Renal Disease in MRL/lpr Mice

Autor: Damian M. Kraus, V. Michael Holers, Lihua Bao, Mark Haas, Richard J. Quigg, Jonathan K. Rakstang, Bradley K. Hack

Publikováno v: Journal of the American Society of Nephrology. 14:670-679

Complement receptor 1-related gene/protein y (Crry) in rodents is a potent membrane complement regulator that inhibits complement C3 activation by both classical and alternative pathways. To clarify the role of complement in lupus nephritis, MRL/lpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f34e7ab9a3097420514aa3cef6bcf79
https://doi.org/10.1097/01.asn.0000051597.27127.a1

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Mechanisms of effects of complement inhibition in murine collagen-induced arthritis

Autor: Long H. Huynh, William P. Arend, Damian M. Kraus, Nirmal K. Banda, V. Michael Holers, Alison M. Bendele, Andrea Vondracek

Publikováno v: Arthritis & Rheumatism. 46:3065-3075

Objective To determine the mechanisms of amelioration of collagen-induced arthritis (CIA) in DBA/1J mice by inhibition of complement activation. Methods Mice received 2 intradermal injections of bovine type II collagen (CII), on days 0 and 21. From d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c551b7c371037d5948ed4a144eafdd80
https://doi.org/10.1002/art.10591

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Transgenic Expression of a Soluble Complement Inhibitor Protects Against Renal Disease and Promotes Survival in MRL/lpr Mice

Autor: V. Michael Holers, Mark Haas, K. K. Culhane, Damian M. Kraus, Jessy J. Alexander, Richard J. Quigg, Susan A. Boackle, Randall K. Anderson, Pierce Park, Patrick N. Cunningham, Lihua Bao

Publikováno v: The Journal of Immunology. 168:3601-3607

To investigate the role of complement in lupus nephritis, we used MRL/lpr mice and a transgene overexpressing a soluble complement regulator, soluble CR1-related gene/protein y (sCrry), both systemically and in kidney. Production of sCrry in sera led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e05c56436f7c30bda44beb915e7f8c
https://doi.org/10.4049/jimmunol.168.7.3601

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Inhibiting the Complement System Does Not Reduce Injury in Renal Ischemia Reperfusion

Autor: Patrick N. Cunningham, Lihua Bao, V. Michael Holers, Mark Haas, Damian M. Kraus, Richard J. Quigg, Pierce Park, Jessy J. Alexander, Joel M. Guthridge

Publikováno v: Journal of the American Society of Nephrology. 12:1383-1390

The complex pathogenesis of ischemia reperfusion injury (IRI) includes endothelial expression of adhesion molecules, leukocyte recruitment and activation, reactive oxygen species production, and apoptotic and necrotic cell death. A role for complemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d76d9e229cfb659b920daa0f42491e
https://doi.org/10.1681/asn.v1271383

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Transgenic Mice Overexpressing the Complement Inhibitor Crry as a Soluble Protein Are Protected from Antibody-induced Glomerular Injury

Autor: Richard J. Quigg, D. Berthiaume, Damian M. Kraus, Jessy J. Alexander, V.M. Holers, Chun He, Alice Lim

Publikováno v: The Journal of Experimental Medicine

Complement receptor 1-related gene/protein y (Crry) is a potent murine membrane complement regulator that inhibits classical and alternative pathway C3 convertases. In nephrotoxic serum (NTS) nephritis, injected antibodies (Abs) bind to glomeruli, le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7126784178c5817ed8b08adc18a8f87
https://doi.org/10.1084/jem.188.7.1321

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