Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Damian M. Cummings"'
Autor:
Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A. Salih, Takshashila Tripathi, Frances A. Edwards, Damian M. Cummings
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-20 (2021)
Abstract Background Microglia are active modulators of Alzheimer’s disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relationships and investigat
Externí odkaz:
https://doaj.org/article/c241915267b041949cedfb8d22f43f62
Autor:
Evelyn Medawar, Tiffanie A. Benway, Wenfei Liu, Taylor A. Hanan, Peter Haslehurst, Owain T. James, Kenrick Yap, Laurenz Muessig, Fabia Moroni, Muzammil A. Nahaboo Solim, Gaukhar Baidildinova, Rui Wang, Jill C. Richardson, Francesca Cacucci, Dervis A. Salih, Damian M. Cummings, Frances A. Edwards
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 422-435 (2019)
Background: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APPSwe/PSEN1M146V) show altered synaptic transmission, compatible with increased physiological f
Externí odkaz:
https://doaj.org/article/5722d6f40c0e41faafdec353fb1fb985
Autor:
Mar Matarin, Dervis A. Salih, Marina Yasvoina, Damian M. Cummings, Sebastian Guelfi, Wenfei Liu, Muzammil A. Nahaboo Solim, Thomas G. Moens, Rocio Moreno Paublete, Shabinah S. Ali, Marina Perona, Roshni Desai, Kenneth J. Smith, Judy Latcham, Michael Fulleylove, Jill C. Richardson, John Hardy, Frances A. Edwards
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 633-644 (2015)
We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of “amyloid” transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and “TAU” transgenic mice (mutant human MAPT gene). Micr
Externí odkaz:
https://doaj.org/article/0334cf3976634ae2a36a01bc25cb4353
Autor:
Joshua J. W. Paulin, Peter Haslehurst, Alexander D. Fellows, Wenfei Liu, Joshua D. Jackson, Zelah Joel, Damian M. Cummings, Frances A. Edwards
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines. Strong stimuli can also be pathological, causing a homeostatic response, depressing and sh
Externí odkaz:
https://doaj.org/article/1968c8857feb4f82a552d36a07e26ca0
Autor:
Sara J. Baldock, Punarja Kevin, Garry R. Harper, Rebecca Griffin, Hussein H. Genedy, M. James Fong, Zhiyi Zhao, Zijian Zhang, Yaochun Shen, Hungyen Lin, Catherine Au, Jack R. Martin, Mark D. Ashton, Mathew J. Haskew, Beverly Stewart, Olga Efremova, Reza N. Esfahani, Hedley C. A. Emsley, John B. Appleby, David Cheneler, Damian M. Cummings, Alexandre Benedetto, John G. Hardy
Publikováno v:
Advanced Materials Technologies. :2201274
3D objects with integrated electronics are produced using an additive manufacturing approach relying on multiphoton fabrication (direct laser writing, (DLW)). Conducting polymer-based structures (with micrometer-millimeter scale features) are printed
Autor:
Frances A. Edwards, David Cheneler, Garry R. Harper, Amelia V. Edwards, John G. Hardy, Damian M. Cummings, Christopher Hann, Hanna Leeson, Diane T. Spencer, Kiron Rajeev, Wan Li Low, Allan Rennie, Larysa Tymczyszyn, Mark D. Ashton, Pierre L. Martin‐Hirsch, Henry Ivill
Publikováno v:
Materials Advances. 2:1600-1605
Multielectrode arrays (MEAs) are electrical devices that transduce (record/deliver) cellular voltage signals. Commercially available MEAs are expensive and here we provide proof of concept for the application of an additive manufacturing approach to
Autor:
Jack I. Wood, Eugenia Wong, Ridwaan Joghee, Aya Balbaa, Karina S. Vitanova, Katie M. Stringer, Alison Vanshoiack, Stefan-Laural J. Phelan, Francesca Launchbury, Sneha Desai, Takshashila Tripathi, Jörg Hanrieder, Damian M. Cummings, John Hardy, Frances A. Edwards
Publikováno v:
Cell reports. 41(8)
Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG) expression in microglia-touching plaques, neighboring plaques, and far from plaques in an aged Alzheimer's mouse model with late plaque development. In 18-month-ol
Autor:
Jack Wood, Eugenia Wong, Ridwaan Joghee, Aya Balbaa, Karina S. Vitanova, Alison Vanshoiack, Stefan-Laural J. Phelan, Francesca Launchbury, Sneha Desai, Takshashila Tripathi, Jörg Hanrieder, Damian M. Cummings, John Hardy, Frances A. Edwards
Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG) expression in microglia touching plaques, neighboring plaques, and far from plaques in 18-month-oldAPPNLF/NLFknock-in mice with and without the Alzheimer’s disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3e36fe6fab6307b22c36a3dca65b9a
https://doi.org/10.1101/2022.01.26.477873
https://doi.org/10.1101/2022.01.26.477873
Autor:
Natalie Wong, Karina S. Vitanova, Jack Wood, Chloe M. Hall, Carlijn Peerboom, Takshashila Tripathi, Victoria C. Smith, Frances A. Edwards, Takaomi C. Saido, John G. Hardy, Damian M. Cummings, Bart De Strooper, Rui Wang, Takashi Saito, Diana P. Benitez, Dhaval D. Joshi, Dervis A. Salih, Katie M. Stringer, Shenyi Jiang, Jörg Hanrieder
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-20 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-20 (2021)
Funder: Cure Alzheimer's Fund; doi: http://dx.doi.org/10.13039/100007625
Funder: UK Dementia Research Institute (GB)
Funder: Censejo Nacional de Ciencia Tecnilogia (MX)
Funder: Alzheimerfonden; doi: http://dx.doi.org/10.13039/501100008
Funder: UK Dementia Research Institute (GB)
Funder: Censejo Nacional de Ciencia Tecnilogia (MX)
Funder: Alzheimerfonden; doi: http://dx.doi.org/10.13039/501100008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121253db83740465e799f00b52cbdcfd