Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Damian J, Tyler"'
Autor:
Ayaka Shinozaki, Juan D. Sanchez-Heredia, Markus P. Andersen, Mohsen Redda, Duy A. Dang, Esben S. S. Hansen, Rolf F. Schulte, Christoffer Laustsen, Damian J. Tyler, James T. Grist
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract As hyperpolarized (HP) carbon-13 (13C) metabolic imaging is clinically translated, there is a need for easy-to-implement, fast, and robust imaging techniques. However, achieving high temporal resolution without decreasing spatial and/or spec
Externí odkaz:
https://doaj.org/article/a59f0582ba5d4c49b151372016d4d8c8
Autor:
Andrew Tyler, Moritz J. Hundertmark, Jack J. Miller, Oliver Rider, Damian J. Tyler, Ladislav Valkovič
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Motivation:31P magnetic resonance spectroscopic imaging (31P MRSI) is a powerful technique for investigating the metabolic effects of treatments for heart failure in vivo, allowing a better understanding of their mechanism of action in patient cohort
Externí odkaz:
https://doaj.org/article/971d2dad7e0b499bb51c311fd9145cdb
Autor:
James T. Grist, Nikolaj Bøgh, Esben Søvsø Hansen, Anna M. Schneider, Richard Healicon, Vicky Ball, Jack J. J. J. Miller, Sean Smart, Yvonne Couch, Alastair M. Buchan, Damian J. Tyler, Christoffer Laustsen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Hyperpolarized carbon-13 magnetic resonance imaging is a promising technique for in vivo metabolic interrogation of alterations between health and disease. This study introduces a formalism for quantifying the metabolic information in hyperp
Externí odkaz:
https://doaj.org/article/dfd73cea6f4a41c088eadc74c2a3dd37
Autor:
Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are incompletely characterised, but animal and human experiments suggest the involvement of signalling pathways co-dependent upon oxygen and iron availability, inc
Externí odkaz:
https://doaj.org/article/02103a8a32c048e69a723768ec05c297
Autor:
Jonathan M. Hazlehurst, Teegan Reina Lim, Catriona Charlton, Jack J. Miller, Laura L. Gathercole, Thomas Cornfield, Nikolaos Nikolaou, Shelley E. Harris, Ahmad Moolla, Nantia Othonos, Lisa C. Heather, Thomas Marjot, Damian J. Tyler, Carolyn Carr, Leanne Hodson, Jane McKeating, Jeremy W. Tomlinson
Publikováno v:
Metabolism Open, Vol 14, Iss , Pp 100177- (2022)
Background and aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. It is tightly associated with an adverse metabolic phenotype (including obesity and type 2 diabetes) as well as with obstructive sleep apnoea (
Externí odkaz:
https://doaj.org/article/4594b0aa997b40519a78b4393c21a3ac
Autor:
Ladislav Valkovič, Andrew Apps, Jane Ellis, Stefan Neubauer, Damian J Tyler, Albrecht Ingo Schmid, Oliver J Rider, Christopher T Rodgers
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269957 (2022)
Phosphorus magnetic resonance spectroscopy (31P-MRS) has previously demonstrated decreased energy reserves in the form of phosphocreatine to adenosine-tri-phosphate ratio (PCr/ATP) in the hearts of patients with type 2 diabetes (T2DM). Recent 31P-MRS
Externí odkaz:
https://doaj.org/article/1099ea84c2954b89b4e0e6fd24e3d833
Autor:
Kerstin N. Timm, Vicky Ball, Jack J. Miller, Dragana Savic, James A. West, Julian L. Griffin, Damian J. Tyler
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Doxorubicin (DOX) is a successful chemotherapeutic widely used for the treatment of a range of cancers. However, DOX can have serious side-effects, with cardiotoxicity and hepatotoxicity being the most common events. Oxidative stress and changes in m
Externí odkaz:
https://doaj.org/article/8a10b9dada5a48a09336a2deff80dd69
Autor:
Donnie Cameron, Adrian Soto-Mota, David R. Willis, Jane Ellis, Nathan E. K. Procter, Richard Greenwood, Neil Saunders, Rolf F. Schulte, Vassilios S. Vassiliou, Damian J. Tyler, Albrecht Ingo Schmid, Christopher T. Rodgers, Paul N. Malcolm, Kieran Clarke, Michael P. Frenneaux, Ladislav Valkovič
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In this acute intervention study, we investigated the potential benefit of ketone supplementation in humans by studying cardiac phosphocreatine to adenosine-triphosphate ratios (PCr/ATP) and skeletal muscle PCr recovery using phosphorus magnetic reso
Externí odkaz:
https://doaj.org/article/0aa98c2f320e495f9d9b0c3c085e257a
Autor:
Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/5fd6d84b073f4868bfa0e011f96222a9
Autor:
John Kurhanewicz, Daniel B. Vigneron, Jan Henrik Ardenkjaer-Larsen, James A. Bankson, Kevin Brindle, Charles H. Cunningham, Ferdia A. Gallagher, Kayvan R. Keshari, Andreas Kjaer, Christoffer Laustsen, David A. Mankoff, Matthew E. Merritt, Sarah J. Nelson, John M. Pauly, Philips Lee, Sabrina Ronen, Damian J. Tyler, Sunder S. Rajan, Daniel M. Spielman, Lawrence Wald, Xiaoliang Zhang, Craig R. Malloy, Rahim Rizi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 1-16 (2019)
This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging’s (MRI’s) widespread clinical use, and provid
Externí odkaz:
https://doaj.org/article/84ebe3efefdc40839f297b3d92907a8a