Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Damian Houde"'
Autor:
Sriram Sathyanarayanan, Dalia Burzyn, Su Chul Jang, Sonya Haupt, Mcconnell Russell E, Scott Estes, Charan Leng, Ke Xu, James E. Thornton, Raymond J. Moniz, Kyriakos D. Economides, Nikki L. Ross, Youniss Madeleine, Rane A. Harrison, Olga Burenkova, Chang Ling Sia, Kevin Dooley, Martin Shelly, Jonathan D. Finn, Jorge Sanchez-Salazar, Kulman John D, Bryan D. Choi, Damian Houde, Christine McCoy, Nuruddeen D. Lewis, Katherine Kirwin, Leonid Gaidukov, Williams Douglas E
Publikováno v:
Mol Ther
Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of exogenous cargo tethered to the EV surface or packaged inside the lumen are key strategies for gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbabea1bba95f566b0264c85c6b11c8
https://doi.org/10.1016/j.ymthe.2021.01.020
https://doi.org/10.1016/j.ymthe.2021.01.020
Autor:
Damian Houde, Jake W. Pawlowski, Tyler Carlage, Marina Feschenko, Adriana Bajardi-Taccioli, Igor A. Kaltashov
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 151:133-144
Monoclonal antibodies (mAbs) are the fastest growing class of biopharmaceuticals. The specific therapeutic tasks vary among different mAbs, which may include neutralization of soluble targets, activation of cytotoxic pathways, targeted drug delivery,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1381797f16d4a6035e1d3717e4b64b2e
https://doi.org/10.1016/j.jpba.2017.12.061
https://doi.org/10.1016/j.jpba.2017.12.061
Autor:
Zoran Sosic, Igor A. Kaltashov, Damian Houde, Iva Turyan, Khaja Muneeruddin, Ruth Frenkel, Cedric E. Bobst
Publikováno v:
The Analyst. 142:336-344
Detailed profiling of both enzymatic (e.g., glycosylation) and non-enzymatic (e.g., oxidation and deamidation) post-translational modifications (PTMs) is frequently required for the quality assessment of protein-based drugs. Challenging as it is, thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44afcb1e99f69ddee5eb2532874b5039
https://doi.org/10.1039/c6an02041k
https://doi.org/10.1039/c6an02041k
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3278-3289
Characterization of immunoglobulin solutions at high concentrations represents a significant challenge. A current trend in the biopharmaceutical industry is to manufacture highly concentrated drug products, which can be used to deliver high doses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f3046ad95cd0f5542247e1cee875c8
https://doi.org/10.1016/j.xphs.2016.07.021
https://doi.org/10.1016/j.xphs.2016.07.021
Autor:
Qiu Danwen, Joseph Arndt, Damian Houde, Bang-Jin Gong, Chao Quan, Christian Code, Kasper D. Rand, Pepinsky R Blake
Publikováno v:
Pharmaceutical Research. 33:1383-1398
Oligosaccharides play diverse and unpredictable functional roles when attached to proteins and are a largely unexplored scaffold for deconstructing and attributing novel functions to proteins during drug development. Here, the glycoprotein Artemin (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2d15c0190cb56e9a90556c516d70d6
https://doi.org/10.1007/s11095-016-1880-x
https://doi.org/10.1007/s11095-016-1880-x
Publikováno v:
Journal of the American Society for Mass Spectrometry. 27:669-676
When highly concentrated, an antibody solution can exhibit unusual behaviors, which can lead to unwanted properties, such as increased levels of protein aggregation and unusually high viscosity. Molecular modeling, along with many indirect biophysica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506f75b4f3d94743894036cf8d55fcd1
https://doi.org/10.1007/s13361-015-1331-7
https://doi.org/10.1007/s13361-015-1331-7
Autor:
Olivia Henderson, Pavel Landsman, Deniz B. Temel, Andrea Spencer, Mark L. Brader, Fabian Vega, Damian Houde, Shujun Bai, Daniel P. DeCollibus
Publikováno v:
Journal of Pharmaceutical Sciences. 105:50-63
The evaluation of stability with respect to particles in prefilled syringes is complicated by the presence of silicone oil. The mobility, colloidal characteristics, and kinetic instability of silicone oil in contact with a protein formulation may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d7a7a76bed483f63041b9ff1447a08
https://doi.org/10.1016/j.xphs.2015.10.012
https://doi.org/10.1016/j.xphs.2015.10.012
Publikováno v:
Journal of Pharmaceutical Sciences. 104:3984-3989
Protein self-association or aggregation is a property of significant concern for biopharmaceutical products due to the potential ability of aggregates to cause adverse toxicological and immunological effects. Thus, during the development of a protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028601b6d2b3619239040d8fad558f5e
https://doi.org/10.1002/jps.24616
https://doi.org/10.1002/jps.24616
Autor:
Tiffany F. Chen, Stephen L. Sazinsky, David J. DiLillo, Julie Bird, Huawei Qiu, Kevin K. Li, John R. Engen, K. Dane Wittrup, Jeffrey V. Ravetch, Damian Houde, George T. Cheng
Publikováno v:
PMC
© 2017 Elsevier Ltd The binding of human IgG1 to human Fc gamma receptors (hFcγRs) is highly sensitive to the presence of a single N-linked glycosylation site at asparagine 297 of the Fc, with deglycosylation resulting in a complete loss of hFcγR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e211e3a765a22c223837394b25362cf
https://pubmed.ncbi.nlm.nih.gov/28694069
https://pubmed.ncbi.nlm.nih.gov/28694069