Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Damian Graczyk"'
Autor:
Rafał Jastrząb, Rafał Tomecki, Aneta Jurkiewicz, Damian Graczyk, Agnieszka K. Szczepankowska, Jennifer Mytych, Damian Wolman, Pawel Siedlecki
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, posing a serious public health challenge that necessitates the development of new therapeutics, therapies, and prevention methods. Among the various therapeuti
Externí odkaz:
https://doaj.org/article/f921edc8c32a40359c88a84053354c17
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13475 (2021)
In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a p
Externí odkaz:
https://doaj.org/article/d6c9fec8f4bb4c1e9a153b6802dec1f7
Autor:
Damian Graczyk, Aneta Jurkiewicz
Publikováno v:
Gene. 831:146548
Macrophages are transcriptionally highly dynamic cell type, rapidly adapting to a changing environment to execute innate immune functions. Activation of macrophages with lipopolysaccharides (LPS), a major component of the outer membrane of most Gram-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c8dc8d8943ce972d1251b34bee6051
https://doi.org/10.1016/j.gene.2022.146548
https://doi.org/10.1016/j.gene.2022.146548
Autor:
Neuton Gorjão, Magdalena Boguta, Theodoros Kantidakis, Małgorzata Cieśla, Aneta Jurkiewicz, Ewa Leśniewska, Robert J. White, Damian Graczyk
Publikováno v:
Molecular and Cellular Biology
Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a drug that is widely used for immunosuppression in organ transplantation and autoimmune diseases, as well as anticancer chemotherapy. It inhibits IMP dehydrogenase, a rate-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ee918ad318711cafbdc37c856c933c
https://publications.aston.ac.uk/id/eprint/40781/1/MCB.00294_19.full.pdf0.pdf
https://publications.aston.ac.uk/id/eprint/40781/1/MCB.00294_19.full.pdf0.pdf
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:320-329
The synthesis of transfer RNA (tRNA) is directed by RNA polymerase III (Pol III) specialized in high-level transcription of short DNA templates. Pol III recruitment to tRNA genes is controlled by two general initiation factors, TFIIIB and TFIIIC. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c65d1652a6f8a6c6536f0009bc48b9
https://doi.org/10.1016/j.bbagrm.2018.01.011
https://doi.org/10.1016/j.bbagrm.2018.01.011
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13475, p 13475 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c948f7701490b4f9fc450e9750f1ced
https://doi.org/10.3390/ijms222413475
https://doi.org/10.3390/ijms222413475
Publikováno v:
ONCOGENE, 34(40), 5152-5162. Nature Publishing Group
Oncogene
Oncogene
Tumour cells often acquire the ability to escape cell death, a key event leading to the development of cancer. In almost half of all human cancers, the capability to induce cell death is reduced by the mutation and inactivation of p53, a tumour suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e53220ced744480791572c2519ce4f6
https://hdl.handle.net/11370/6669a56f-a0b7-4586-91f5-617038550836
https://hdl.handle.net/11370/6669a56f-a0b7-4586-91f5-617038550836
Autor:
Magdalena Boguta, Olivier Lefebvre, Dominika Wichtowska, Ewa Morawiec, Christine Conesa, Damian Graczyk
Publikováno v:
Gene. 526:16-22
Maf1 is a negative regulator of RNA polymerase III (Pol III) in yeast. Maf1-depleted cells manifest elevated tRNA transcription and inability to grow on non-fermentable carbon source, such as glycerol. Using genomic microarray approach, we examined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b9ef2a8260bcac3cd882e394e5fe80
https://doi.org/10.1016/j.gene.2013.04.055
https://doi.org/10.1016/j.gene.2013.04.055
Inflammation in the tumor microenvironment has many tumor-promoting effects. In particular, tumor-associated macrophages (TAMs) produce many cytokines which can support tumor growth by promoting survival of malignant cells, angiogenesis, and metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78f3a7fd32f1be9a0479fc48b89e61b
https://europepmc.org/articles/PMC4405649/
https://europepmc.org/articles/PMC4405649/
Autor:
Magdalena Boguta, Damian Graczyk
Publikováno v:
Proceedings of the National Academy of Sciences. 108
We recently reported (1) that casein kinase II (CK2)-mediated phosphorylation of Maf1 stimulates polymerase III (Pol III) transcription upon transfer of yeast from repressive conditions in glycerol medium to medium with glucose. Willis et al. (2) hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315116e7a794ff781021881a7523636c
https://doi.org/10.1073/pnas.1107626108
https://doi.org/10.1073/pnas.1107626108