A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons

Autor: Emily F. Mendez, Sandra L. Grimm, Laura Stertz, Damian Gorski, Sai V. Movva, Katherine Najera, Karla Moriel, Thomas D. Meyer, Gabriel R. Fries, Cristian Coarfa, Consuelo Walss-Bass

Publikováno v: Frontiers in Psychiatry, Vol 14 (2023)

IntroductionHuman-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as

Externí odkaz: https://doaj.org/article/e69ef664aef746999f9747cf0a007401

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Autor: Jifeng Bian, Sehun Kim, Sarah J Kane, Jenna Crowell, Julianna L Sun, Jeffrey Christiansen, Eri Saijo, Julie A Moreno, James DiLisio, Emily Burnett, Sandra Pritzkow, Damian Gorski, Claudio Soto, Terry J Kreeger, Aru Balachandran, Gordon Mitchell, Michael W Miller, Romolo Nonno, Turid Vikøren, Jørn Våge, Knut Madslien, Linh Tran, Tram Thu Vuong, Sylvie L Benestad, Glenn C Telling

Publikováno v: PLoS Pathogens, Vol 17, Iss 7, p e1009748 (2021)

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrPC, by its infectious conformation, PrPSc. Following its d

Externí odkaz: https://doaj.org/article/bea6273ddd5944c1a6d5966be71ea6e1

Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease

Autor: Damian Gorski, Megan Klassen, Claudio Soto, Michael B. Coulthart, Jessy A Slota, Sandra Pritzkow, Gordon Mitchell, Stephanie A. Booth, Catherine Robertson, Sarah J. Medina, Christine Mesa

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports

Chronic wasting disease (CWD) is an emerging infectious prion disorder that is spreading rapidly in wild populations of cervids in North America. The risk of zoonotic transmission of CWD is as yet unclear but a high priority must be to minimize furth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ee0d9b478eccb5e62a5a2a3996cd1f
https://doaj.org/article/af040d673aa34dee92178211e6bf509e

North American and Norwegian Chronic Wasting Disease Prions Exhibit Different Potential for Interspecies Transmission and Zoonotic Risk

Autor: Frank Ramirez, Glenn C. Telling, Claudio Soto, Damian Gorski, Sandra Pritzkow, Sylvie L. Benestad

Publikováno v: J Infect Dis

Background Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting various species of wild and captive cervids. The risk that CWD poses to cohabiting animals or more importantly to humans is largely unknown. Methods In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b536d4bba761698a0245b332e34e63
https://europepmc.org/articles/PMC8807243/

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Autor: Bian, Jifeng¹ (AUTHOR), Kim, Sehun¹ (AUTHOR), Kane, Sarah J.¹ (AUTHOR), Crowell, Jenna¹ (AUTHOR), Sun, Julianna L.^1,2 (AUTHOR), Christiansen, Jeffrey¹ (AUTHOR), Saijo, Eri¹ (AUTHOR), Moreno, Julie A.¹ (AUTHOR), DiLisio, James¹ (AUTHOR), Burnett, Emily¹ (AUTHOR), Pritzkow, Sandra³ (AUTHOR), Gorski, Damian³ (AUTHOR), Soto, Claudio³ (AUTHOR), Kreeger, Terry J.⁴ (AUTHOR), Balachandran, Aru⁵ (AUTHOR), Mitchell, Gordon⁵ (AUTHOR), Miller, Michael W.⁶ (AUTHOR), Nonno, Romolo⁷ (AUTHOR), Vikøren, Turid⁸ (AUTHOR), Våge, Jørn⁸ (AUTHOR)

Publikováno v: PLoS Pathogens. 7/26/2021, Vol. 17 Issue 7, p1-33. 33p.