Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Damian Garbicz"'
Autor:
Karolina Ferenc, Michał Marcinkowski, Jarosław Olszewski, Paweł Kowalczyk, Tomaš Pilžys, Damian Garbicz, Naser Dib, Bianka Świderska, Piotr Matyba, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract To reveal the sources of obesity and type 2 diabetes (T2D) in humans, animal models, mainly rodents, have been used. Here, we propose a pig model of T2D. Weaned piglets were fed high fat/high sugar diet suppling 150% of metabolizable energy.
Externí odkaz:
https://doaj.org/article/a1890a23242344b092811861fc4bb6a7
Autor:
Damian Mielecki, Elżbieta Grzesiuk, Anna Bednarska, Damian Garbicz, Bianka Świderska, Malgorzata Grzesiuk
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 249, Iss , Pp 114372- (2023)
Pharmaceuticals used in human medicine contaminate freshwater ecosystems. Chemotherapeutics applied in cancer treatment are found in freshwaters at low concentrations (in the range of ng L−1) which, however, can be toxic or mutagenic to aquatic org
Externí odkaz:
https://doaj.org/article/b8a252876fb9450593b1aa29e020d870
Autor:
Damian Garbicz, Piotr Tobiasz, Filip Borys, Tomasz Pilżys, Michał Marcinkowski, Marcin Poterała, Elżbieta Grzesiuk, Hanna Krawczyk
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 123, Iss , Pp 109781- (2020)
In the present study, the synthesis and cytotoxic effect of six stilbenes and three oxepine derivatives against two cancerous – HeLa and U87, and two normal – EUFA30 and HEK293 cell lines has been reported. The results of cytotoxic assay and flow
Externí odkaz:
https://doaj.org/article/d750c2163e8544a5be79827be82252bd
Autor:
Michał Marcinkowski, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Kaja Przygońska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jarosław Poznański, Elżbieta Grzesiuk
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10869 (2021)
FTO is an N6-methyladenosine demethylase removing methyl groups from nucleic acids. Several studies indicate the creation of FTO complexes with other proteins. Here, we looked for regulatory proteins recognizing parts of the FTO dioxygenase region. I
Externí odkaz:
https://doaj.org/article/2da0958bbf674e47a4518742b0d01479
Autor:
Bartosz Bieszczad, Damian Garbicz, Marta Świtalska, Marta K. Dudek, Dawid Warszycki, Joanna Wietrzyk, Elżbieta Grzesiuk, Adam Mieczkowski
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 851 (2021)
Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl grou
Externí odkaz:
https://doaj.org/article/70b24e38a9714d469f45b6920572de9f
Autor:
Michał Marcinkowski, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Damian Mielecki, Grzegorz Nowaczyk, Michał Taube, Maciej Gielnik, Maciej Kozak, Maria Winiewska-Szajewska, Ewa Szołajska, Janusz Dębski, Agnieszka M. Maciejewska, Kaja Przygońska, Karolina Ferenc, Elżbieta Grzesiuk, Jarosław Poznański
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4512 (2021)
The FTO protein is involved in a wide range of physiological processes, including adipogenesis and osteogenesis. This two-domain protein belongs to the AlkB family of 2-oxoglutarate (2-OG)- and Fe(II)-dependent dioxygenases, displaying N6-methyladeno
Externí odkaz:
https://doaj.org/article/2b261959dc6147a9b636ed04b983367f
Autor:
Bartosz Bieszczad, Damian Garbicz, Damian Trzybiński, Marta K. Dudek, Krzysztof Woźniak, Elżbieta Grzesiuk, Adam Mieczkowski
Publikováno v:
Molecules, Vol 25, Iss 12, p 2855 (2020)
Unsymmetrically N-substituted and N,N’-disubstituted 5,12-dihydrodibenzo [b,f][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the dibenzodiazocine scaffold were introduced at the stages of proper select
Externí odkaz:
https://doaj.org/article/dc8da00a1da343ffbfc8935e2775f0ed
Autor:
Bartosz Bieszczad, Damian Garbicz, Damian Trzybiński, Damian Mielecki, Krzysztof Woźniak, Elżbieta Grzesiuk, Adam Mieczkowski
Publikováno v:
Molecules, Vol 25, Iss 4, p 906 (2020)
A novel approach for the synthesis of unsymmetrically substituted dibenzo[b,f][1,5]diazocine-6,12(5H,11H)diones has been developed. This facile three-step method uses variously substituted 1H-benzo[d][1,3]oxazine-2,4-diones (isatoic anhydrides) and 2
Externí odkaz:
https://doaj.org/article/c89be6beab5d40119fff5932365846d4
Autor:
Małgorzata Grzesiuk, Damian Mielecki, Tomasz Pilżys, Damian Garbicz, Michał Marcinkowski, Elżbieta Grzesiuk
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197416 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0195366.].
Externí odkaz:
https://doaj.org/article/ebda1947a85e4544ae6e1b22fc884164
Autor:
Małgorzata Grzesiuk, Damian Mielecki, Tomasz Pilżys, Damian Garbicz, Michał Marcinkowski, Elżbieta Grzesiuk
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195366 (2018)
The waste of commonly used medicines is known to contaminate freshwater ecosystems. Pharmaceuticals can be toxic, mutagenic, or modifying to freshwater organisms even at low concentrations if consider their permanent presence in the environment. Chem
Externí odkaz:
https://doaj.org/article/4c4e3b39a34c4bf9bf90548fa6c5155b