Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Damian F.J. Purcell"'
Autor:
Terry M. Nolan, Georgia Deliyannis, Maryanne Griffith, Sabine Braat, Lilith F. Allen, Jennifer Audsley, Amy W. Chung, Marcin Ciula, Nicholas A. Gherardin, Michelle L. Giles, Tom P. Gordon, Samantha L. Grimley, Lana Horng, David C. Jackson, Jennifer A. Juno, Katherine Kedzierska, Stephen J. Kent, Sharon R. Lewin, Mason Littlejohn, Hayley A. McQuilten, Francesca L. Mordant, Thi H.O. Nguyen, Vanessa Pac Soo, Briony Price, Damian F.J. Purcell, Pradhipa Ramanathan, Samuel J. Redmond, Steven Rockman, Zheng Ruan, Joseph Sasadeusz, Julie A. Simpson, Kanta Subbarao, Stewart A. Fabb, Thomas J. Payne, Asuka Takanashi, Chee Wah Tan, Joseph Torresi, Jing Jing Wang, Lin-Fa Wang, Hareth Al-Wassiti, Chinn Yi Wong, Sophie Zaloumis, Colin W. Pouton, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104878- (2023)
Summary: Background: SARS-CoV-2 booster vaccination should ideally enhance protection against variants and minimise immune imprinting. This Phase I trial evaluated two vaccines targeting SARS-CoV-2 beta-variant receptor-binding domain (RBD): a recomb
Externí odkaz:
https://doaj.org/article/759603e2b16e4eff9551a0f453f831d4
Autor:
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104574- (2023)
Summary: Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during sto
Externí odkaz:
https://doaj.org/article/3f8a77f37e1f498db21c0e05005ef2d3
Autor:
Behnaz Heydarchi, Damian F.J. Purcell
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101911- (2022)
Summary: We describe herein a protocol for production of chimeric bovine-human monoclonal antibodies (mAbs) from vaccinated cows. The genes of HIV-1-specific single B cells are amplified by reverse transcription-polymerase chain reaction (RT-PCR), cl
Externí odkaz:
https://doaj.org/article/8025063b35ac4af88f7fdd196535f7d2
Autor:
Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105259- (2022)
Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here,
Externí odkaz:
https://doaj.org/article/8d6f566f8f3c4f6d9a283613b3b50fb7
Autor:
Thomas S. Fulford, Huy Van, Nicholas A. Gherardin, Shuning Zheng, Marcin Ciula, Heidi E. Drummer, Samuel Redmond, Hyon-Xhi Tan, Irene Boo, Rob J. Center, Fan Li, Samantha L. Grimley, Bruce D. Wines, Thi H.O. Nguyen, Francesca L. Mordant, Paula Ellenberg, Louise C. Rowntree, Lukasz Kedzierski, Allen C. Cheng, Denise L. Doolan, Gail Matthews, Katherine Bond, P. Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Deborah A. Williamson, Damian F.J. Purcell, David A. Anderson, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103729- (2021)
Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from
Externí odkaz:
https://doaj.org/article/b797a15ea4c145e7a13177048c7b5ebe
Autor:
Ester Lopez, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O’Neill, Phillip Pymm, Samuel J. Redmond, Wen Shi Lee, Nicholas A. Gherardin, Adam K. Wheatley, Jennifer A. Juno, Kevin J. Selva, Samantha K. Davis, Samantha L. Grimley, Leigh Harty, Damian F.J. Purcell, Kanta Subbarao, Dale I. Godfrey, Stephen J. Kent, Wai-Hong Tham, Amy W. Chung
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly evolving domains, which can result in the emergence of immune escape mutations, limiting the effectiveness of vaccines an
Externí odkaz:
https://doaj.org/article/6496c3fb4c0b4160a25ed36ea7212210
Autor:
Brendan E. Russ, Moshe Olshansky, Jasmine Li, Michelle L.T. Nguyen, Linden J. Gearing, Thi H.O. Nguyen, Matthew R. Olson, Hayley A. McQuilton, Simone Nüssing, Georges Khoury, Damian F.J. Purcell, Paul J. Hertzog, Sudha Rao, Stephen J. Turner
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3624-3636 (2017)
Summary: Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that control these changes are largely unknown. Using ChIP-seq for specific histone po
Externí odkaz:
https://doaj.org/article/caa7cee84b0340d08a22a2756c89adcf
Autor:
Talia M. Mota, Georges Khoury, Wei Zhao, James McMahon, Steven G. Deeks, Paul U. Cameron, Damian F.J. Purcell, Sharon R. Lewin
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss , Pp 9- (2017)
Externí odkaz:
https://doaj.org/article/c9e0fa7dbcaa4d28b1544690ad396087
Publikováno v:
Viruses, Vol 11, Iss 6, p 507 (2019)
A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T cell responses would be optimal for preventing HIV-1 transmissions. Replication incompetent HIV-1 virus-like particles (
Externí odkaz:
https://doaj.org/article/20913755c99a4caa98484f19f2ca528a
Autor:
Behnaz Heydarchi, Danielle S. Fong, Hongmei Gao, Natalia A. Salazar-Quiroz, Jack M. Edwards, Christopher A. Gonelli, Samantha Grimley, Turgut E. Aktepe, Charlene Mackenzie, William J. Wales, Marit J. van Gils, Albert Cupo, Isabelle Rouiller, Paul R. Gooley, John P. Moore, Rogier W. Sanders, David Montefiori, Ashish Sethi, Damian F.J. Purcell
Publikováno v:
Cell Reports Medicine, 3(5):100635. Cell Press
Human immunodeficiency virus type 1 (HIV-1) vaccination of cows has elicited broadly neutralizing antibodies (bNAbs). In this study, monoclonal antibodies (mAbs) are isolated from a clade A (KNH1144 and BG505) vaccinated cow using a heterologous clad