Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Damian C, Crowther"'
Autor:
Zengjie Xia, Emily E. Prescott, Agnieszka Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A. Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, Michael R. Strickland, Hong Jiang, Peter Thornton, Damian C. Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M. Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B. Wharton, David M. Holtzman, Tarja Malm, Rohan T. Ranasinghe, David Klenerman, Suman De
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions bet
Externí odkaz:
https://doaj.org/article/65a320a335c64d1798e94a4de6e507f4
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 10, Pp 1187-1199 (2017)
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired wit
Externí odkaz:
https://doaj.org/article/151e4c80585d444ea54d194275e185c3
Autor:
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1366-1378 (2017)
Abstract We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2‐expressing human embryoni
Externí odkaz:
https://doaj.org/article/c069149e8d3140e48dd7f555f57c2d71
Autor:
Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 deple
Externí odkaz:
https://doaj.org/article/7b2b3980bb0d47cfbbc1901e8b838972
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 7, Pp 657-667 (2015)
Metals, including iron, are present at high concentrations in amyloid plaques in individuals with Alzheimer's disease, where they are also thought to be cofactors in generating oxidative stress and modulating amyloid formation. In this study, we pres
Externí odkaz:
https://doaj.org/article/4c28afbbf13d4058b39bbce889668a79
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 4, Pp 445-458 (2014)
Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer’s disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosop
Externí odkaz:
https://doaj.org/article/45b02dde27724083952a28eec161f030
Autor:
Graham Belfield, Doris Rassl, Damian C. Crowther, Richard Berks, Ewa Kolosionek, Helen Parfrey, Marisa Coetzee, Nicola Davis, Maryam Clausen, Susan J. Monkley, Overed-Sayer Catherine L, Cory M. Hogaboam, Leire Escudero-Ibarz, Lynne Murray, Leia R. Griffin, Maria Karlsson, Alan Carruthers
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of normal ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e29cb1c4508a83ba2b1e63764115fc
http://europepmc.org/articles/PMC8566588
http://europepmc.org/articles/PMC8566588
Autor:
Zengjie Xia, Emily E. Prescott, Hollie E Wareing, Martyna M Matuszyk, Helen Dakin, Eleni Dimou, Eric Zuo, Yu P. Zhang, Jeff Y.L. Lam, John S. H. Danial, Tom Leah, Katy A. Barnes, Michael Strickland, Hong Jiang, Peter Thornton, Damian C. Crowther, David M. Holtzman, Simon M. Bell, Adrian Higginbottom, Laura Ferraiuolo, Heather Mortiboys, Stephen B. Wharton, Rohan T. Ranasinghe, David Klenerman, Suman De
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d178cf169160d5c45dfdb6da9374332
https://doi.org/10.1101/2021.07.13.452239
https://doi.org/10.1101/2021.07.13.452239
Autor:
Jigna V Patel, Josef T. Kittler, Nicholas J. Brandon, Nicol Birsa, Jack H. Howden, Roland Bürli, Damian C. Crowther, Guillermo López-Doménech, Christian Covill-Cooke, Corinne Morfill
Publikováno v:
The EMBO Journal
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin mitochondrial quality control system in vitro and in vivo. We find that upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305abf2e7580b5c9325788b9c1be8dab
https://doi.org/10.15252/embj.2018100715
https://doi.org/10.15252/embj.2018100715
Autor:
Eleonora Khabirova, Aileen Moloney, Stefan J Marciniak, Julie Williams, David A Lomas, Stephen G Oliver, Giorgio Favrin, David B Sattelle, Damian C Crowther
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102985 (2014)
The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the sev
Externí odkaz:
https://doaj.org/article/59f5395e1eb941d4808ef402ed75ac77