Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge.

Autor: Damian A Oyong, Fergal J Duffy, Maxwell L Neal, Ying Du, Jason Carnes, Katharine V Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D Aitchison, Stephen C De Rosa, Evan W Newell, M Juliana McElrath, Suzanne M McDermott, Kenneth D Stuart

Publikováno v: PLoS Pathogens, Vol 19, Iss 5, p e1011051 (2023)

Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria

Externí odkaz: https://doaj.org/article/5e95f5d58ff341c091cc9cbb0bcf49d6

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

Autor: Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey, Michelle J. Boyle

Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)

Abstract Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on

Externí odkaz: https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Autor: Thi H. O. Nguyen, Jane Davies, Aeron C. Hurt, Carolien E van de Sandt, Malet Aban, Damian A. Oyong, Marios Koutsakos, Kim L. Harland, Steven Y. C. Tong, Jessica R. Webb, Katie L. Flanagan, Cath Blacker, Adam K. Wheatley, Peter C. Doherty, Jane Nelson, Louise C. Rowntree, Amy W. Chung, Timon Damelang, Anngie Everitt, Katherine Kedzierska, Maria Auladell, E. Bridie Clemens, Stephen J. Kent, Luca Hensen, Magdalena Plebanski, Bruce D. Wines, Jessica R. Loughland, P. Mark Hogarth, Adrian Miller

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118(41). National Academy of Sciences

Significance Indigenous populations worldwide are highly susceptible to influenza virus infections. Vaccination with inactivated virus is highly recommended to protect Indigenous populations, including Indigenous Australians. There is no study to dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8177d032c766c8c1ba09d40bd774890
https://doi.org/10.1073/pnas.2109388118

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

Autor: Timothy William, Dean Andrew, Michelle J. Boyle, Christian R. Engwerda, Matthew J. Grigg, James S. McCarthy, Nicholas M. Anstey, Arya SheelaNair, Kim A. Piera, Ashraful Haque, Jessica R. Loughland, Damian A. Oyong, Fabian de Labastida Rivera, Bridget E. Barber

Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Malaria Journal

Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22a4baab7493ce832405d564937a45
https://doi.org/10.1186/s12936-019-2962-0

Assessment of Point-of-Care Diagnostics for G6PD Deficiency in Malaria Endemic Rural Eastern Indonesia

Autor: J. Kevin Baird, Ari W. Satyagraha, Decy Subekti, Ungke Antonjaya, Alida Harahap, Iqbal R. F. Elyazar, Rosalie Elvira, Gonzalo J. Domingo, Damian A. Oyong, Ismail Ekoprayitno Rozi, Arkasha Sadhewa, Denny Feriandika

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004457 (2016)

Background Patients infected by Plasmodium vivax or Plasmodium ovale suffer repeated clinical attacks without primaquine therapy against latent stages in liver. Primaquine causes seriously threatening acute hemolytic anemia in patients having inherit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365b70f9600aa4d26455779b769f9b17
https://doi.org/10.1371/journal.pntd.0004457