Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Damian, Stephan"'
Publikováno v:
British Journal of Pharmacology. 149:199-205
Background and purpose: ATP-sensitive K+ (KATP) channels are composed of pore-forming subunits (Kir6.x) and of sulphonylurea receptors (SUR). Both sulphonylureas and KATP channel openers act by binding to SUR. Sulphonylureas reach their binding site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ffa95ba9fc86380bef59fc345c375d
https://doi.org/10.1038/sj.bjp.0706858
https://doi.org/10.1038/sj.bjp.0706858
Publikováno v:
Diabetologia. 49:2039-2048
Sulfonylureas and glinides close beta cell ATP-sensitive K(+) (K(ATP)) channels to increase insulin release; the concomitant closure of cardiovascular K(ATP) channels, however, leads to complications in patients with cardiac ischaemia. The insulinotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89549a9ede786aeae2f3e295a9a2234
https://doi.org/10.1007/s00125-006-0307-3
https://doi.org/10.1007/s00125-006-0307-3
Autor:
Joseph Bryan, Renate Prager, David Ortiz, Petra Kühner, Marcus Winkler, Ulrich Russ, Damian Stephan, Ulrich Quast
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 385(3)
The pancreatic K(ATP) channel, SUR1/Kir6.2, couples insulin secretion to the plasma glucose level. The channel is an octamer with four Kir6.2 subunits forming the pore and four sulphonylurea receptors (SUR1) regulating channel activity. SUR1 is an AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0827e530625788f8cc7eef12e5722e64
https://pubmed.ncbi.nlm.nih.gov/22083559
https://pubmed.ncbi.nlm.nih.gov/22083559
Background and purpose: The antidiabetic sulphonylurea, glibenclamide, acts by inhibiting the pancreatic ATP-sensitive K+ (KATP) channel, a tetradimeric complex of KIR6.2 and sulphonylurea receptor 1 (KIR6.2/SUR1)4. At room temperature, recovery of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6518106755a7cd0a061a2bad62a13e99
https://europepmc.org/articles/PMC2697833/
https://europepmc.org/articles/PMC2697833/
Publikováno v:
British journal of pharmacology. 145(7)
ATP-sensitive K(+) channels (K(ATP) channels) are complexes of inwardly rectifying K(+) channels (Kir6.x) and sulphonylurea receptors (SURs). Kir6.2-containing channels are closed by ATP binding to Kir6.2, and opened by MgADP binding to SUR. Channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a5d8692cbd498ed2346fb5c08f40fa8
https://pubmed.ncbi.nlm.nih.gov/15895108
https://pubmed.ncbi.nlm.nih.gov/15895108
Autor:
Damian, Stephan, Eva, Stauss, Ulf, Lange, Holger, Felsch, Cornelia, Löffler-Walz, Annette, Hambrock, Ulrich, Russ, Ulrich, Quast
Publikováno v:
British journal of pharmacology. 144(8)
1. ATP-sensitive K(+) channels (K(ATP) channels) are tetradimeric complexes of inwardly rectifying K(+) channels (Kir6.x) and sulphonylurea receptors (SURs). The SURs SUR2A (cardiac) and SUR2B (smooth muscle) differ only in the last 42 amino acids. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69dea685fa034f809c6469a600aa765c
https://pubmed.ncbi.nlm.nih.gov/15711591
https://pubmed.ncbi.nlm.nih.gov/15711591
Publikováno v:
Diabetes. 53
Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by closing the ATP-sensitive K+ channel (KATP channel) in the pancreatic β-cell membrane. KATP channels subserve important functions also in the heart. First, KATP channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d81fd282897c7277cdf685b435c161
https://pubmed.ncbi.nlm.nih.gov/15561904
https://pubmed.ncbi.nlm.nih.gov/15561904