The effective family size of immigrant founders predicts their long-term demographic outcome: from Québec settlers to their 20th-century descendants

Autor: Damian Labuda, Hélène Vézina, Tommy Harding, Emmanuel Milot

Human evolution involves population splits, size fluctuations, founder effects, and admixture. Population history reconstruction based on genetic diversity data routinely relies on simple demographic models while projecting the past. No specific demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b212a4244b90f5721f1875516aa3a7b5
https://doi.org/10.1101/2021.07.25.453708

Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies

Autor: Christoph Preuss, Emmanuel Milot, Dominic Nelson, Hélène Vézina, Gregor Andelfinger, Yixiao Zeng, Marianne de Vriendt, Damian Labuda, Simon Gravel, Claudia Moreau

Publikováno v: The American Journal of Human Genetics. 103:893-906

Learning the transmission history of alleles through a family or population plays an important role in evolutionary, demographic, and medical genetic studies. Most classical models of population genetics have attempted to do so under the assumption t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c34fd41cd171aae696e74c1991ba6
https://doi.org/10.1016/j.ajhg.2018.10.017

Native American admixture in the Quebec founder population.

Autor: Claudia Moreau, Jean-François Lefebvre, Michèle Jomphe, Claude Bhérer, Andres Ruiz-Linares, Hélène Vézina, Marie-Hélène Roy-Gagnon, Damian Labuda

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65507 (2013)

For years, studies of founder populations and genetic isolates represented the mainstream of genetic mapping in the effort to target genetic defects causing Mendelian disorders. The genetic homogeneity of such populations as well as relatively homoge

Externí odkaz: https://doaj.org/article/1c4887638ef94d09b7c4ba6c9852076b

Genotype-based test in mapping cis-regulatory variants from allele-specific expression data.

Autor: Jean Francois Lefebvre, Emilio Vello, Bing Ge, Stephen B Montgomery, Emmanouil T Dermitzakis, Tomi Pastinen, Damian Labuda

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38667 (2012)

Identifying and understanding the impact of gene regulatory variation is of considerable importance in evolutionary and medical genetics; such variants are thought to be responsible for human-specific adaptation and to have an important role in genet

Externí odkaz: https://doaj.org/article/80e86948ec4f4745961a8aa51975cb63

The genomic history of Southern Europe

Autor: Richard Cottiaux, Eadaoin Harney, Iain Mathieson, Elizaveta Veselovskaya, Corinne Thevenet, Georgi Ganetsovski, Philipp W. Stockhammer, Petar Stanev, Douglas J. Kennett, Stefan Chohadzhiev, Adina Boroneanţ, Domenico Lo Vetro, Megan Michel, Nicholas J. Conard, Maleen Leppek, Fanica Veljanovska, Harald Meller, Martina Lari, Clive Bonsall, Michael Bolus, Thomas Higham, Andrej Starović, Darko Komšo, Mario Novak, Ivaylo Lozanov, Maja Čuka, Vanya Petrova, Krum Bacvarov, Alicja Budnik, Cosimo Posth, Cristian Virag, Stanislav Iliev, Wolfgang Haak, Francesca Candilio, Iñigo Olalde, Tamás Hajdu, David Caramelli, Raiko Krauß, Ivor Janković, Swapan Mallick, Matthew Ferry, Ben Krause-Kyora, Maria Teschler-Nicola, Kristin Stewardson, Cătălin Lazăr, Anastasia Papathanasiou, Giulio Catalano, Veneta Handzhyiska, Kendra Sirak, Kathrin Nägele, Kurt W. Alt, Bernard Gély, Ivor Karavanić, Svetlana Venelinova, Nedko Elenski, Dragana Antonović, Ron Pinhasi, Maria Malina, Inna Potekhina, Ivan Valchev, Alexey G. Nikitin, Kath McSweeney, Dusan Boric, Alissa Mittnik, Nick Patterson, Saskia Pfrengle, Angela Simalcsik, Anna Szécsényi-Nagy, Abigail Ash, Malcolm Lillie, Mario Šlaus, Fabio Martini, David Reich, Johannes Krause, Tamás Szeniczey, Bence Viola, Dženi Los, Luca Sineo, Hervé Bocherens, Christophe Cupillard, Yavor Boyadzhiev, Pavel Mirea, Sahra Talamo, Alexandra Kozak, Katerina Harvati, Songül Alpaslan-Roodenberg, Nasreen Broomandkhoshbacht, Marko Menđušić, Gunita Zariņa, Olivia Cheronet, Isil Kucukkalipci, Denise Keating, Dorothée G. Drucker, Stefan Alexandrov, Vladimir Slavchev, Radian Andreescu, Eppie R. Jones, Beatriz Gamarra, Michael Francken, Nadin Rohland, Gloria G. Fortes, Jonas Oppenheimer, Stefania Vai, T. Douglas Price, Sergey Vasilyev, Borislava Galabova, Krassimir Leshtakov, Bisserka Gaydarska, Mende Balázs Gusztáv, Joško Zaninović, Nadezhda Atanassova, Vyacheslav Moiseyev, Josip Burmaz, Daniel Fernandes, Steve Zäuner, Damian Labuda, Frédérique Valentin

Publikováno v: bioRxiv
Nature
Nature, Nature Publishing Group, 2018, 555 (7695), pp.197-203. ⟨10.1038/nature25778⟩
BASE-Bielefeld Academic Search Engine
Volume 555
Issue 7695
Mathieson, I, Alpaslan-Roodenberg, S, Posth, C, Szécsényi-Nagy, A, Rohland, N, Mallick, S K, Olalde, I, Broomandkhoshbacht, N, Candilio, F, Cheronet, O, Fernandes, D N, Ferry, M, Gamarra, B, González-Fortes, G, Haak, W, Harney, E, Jones, E, Keating, D J, Krause-Kyora, B, Kucukkalipci, I, Michel, M, Mittnik, A, Nägele, K, NOVAK, M, Oppenheimer, J, Patterson, N, Pfrengle, S, Sirak, K, Stewardson, K, Vai, S, Alexandrov, S, Alt, K W, Andreescu, R, Antonović, D, Ash, A, Atanassova, N, Bacvarov, K, Gusztáv, M B, Bocherens, H, Bolus, M, Boroneanţ, A, Boyadzhiev, Y, Budnik, B A, Burmaz, J, Chohadzhiev, S, Conard, N J, Cottiaux, R, Čuka, M, Cupillard, C, Drucker, D G, Elenski, N, Francken, M, Galabova, B, Ganetsovski, G, Gély, B, Hajdu, T, Handzhyiska, V, Harvati, K, Higham, T, Iliev, S, Janković, I, Karavanić, I, Kennett, D J, Komšo, D, Kozak, A M, Labuda, D, Lari, M, Lazar, C, Leppek, M, Leshtakov, K, Lo Vetro, D, Los, D, Lozanov, I, Malina, M, Martini, F, McSweeney, K, Meller, H, Mentušić, M, Mirea, P, Moiseyev, V, Petrova, V, Douglas Price, T, Simalcsik, A, Sineo, L, Šlaus, M, Slavchev, V, Stanev, P, Starović, A, Szeniczey, T, Talamo, S, Teschler-Nicola, M, Thevenet, C, Valchev, I, Valentin, F, Vasilyev, S, Veljanovska, F, Venelinova, S, Veselovskaya, E, Viola, B, Virag, C, Zaninović, J, Zaüner, S, Stockhammer, P W, Catalano, G, Krauß, R, Caramelli, D, Zariną, G, Gaydarska, B, Lillie, M, Nikitin, A G, Potekhina, I, Papathanasiou, K A, Borić, D, Bonsall, C, Krause, J, Pinhasi, R & Reich, D 2018, ' The genomic history of southeastern Europe ', Nature, vol. 555, no. 7695, pp. 197-203 . https://doi.org/10.1038/nature25778

Farming was first introduced to southeastern Europe in the mid-7th millennium BCE - brought by migrants from Anatolia who settled in the region before spreading throughout Europe. However, the dynamics of the interaction between the first farmers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54757f3ec713f3a77a418f79afef788f
http://hdl.handle.net/10447/273248