Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Damian, Fermin"'
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Aldehyde dehydrogenase 1, family member A2, is a retinoic acid-synthesizing enzyme encoded by Aldh1a2 in mice and ALDH1A2 in humans. This enzyme is indispensable for kidney development, but its role in kidney physiology and pathophysiology remains to
Externí odkaz:
https://doaj.org/article/2ceb0cffc8fa43e3ab00cd04e3648d55
Autor:
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly und
Externí odkaz:
https://doaj.org/article/a2a886ce9d15408388b2e940336664d3
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Autor:
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O’Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2
Externí odkaz:
https://doaj.org/article/786e05c40b544ed683f2bef88a499a82
Autor:
Sarah E. Graham, Jonas B. Nielsen, Matthew Zawistowski, Wei Zhou, Lars G. Fritsche, Maiken E. Gabrielsen, Anne Heidi Skogholt, Ida Surakka, Whitney E. Hornsby, Damian Fermin, Daniel B. Larach, Sachin Kheterpal, Chad M. Brummett, Seunggeun Lee, Hyun Min Kang, Goncalo R. Abecasis, Solfrid Romundstad, Stein Hallan, Matthew G. Sampson, Kristian Hveem, Cristen J. Willer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Estimated glomerular filtration rate (eGFR) is a measure of kidney function and used to characterize chronic kidney disease. Here, Graham et al. identify 53 novel loci for eGFR in a GWAS meta-analysis, a subset of which are associated with other comm
Externí odkaz:
https://doaj.org/article/7de7f4e3a4e84b4f97be7b7ad13ccb61
Autor:
Jiahao, Liu, Viji, Nair, Yi-Yang, Zhao, Dong-Yuan, Chang, Christine, Limonte, Nisha, Bansal, Damian, Fermin, Felix, Eichinger, Emily C, Tanner, Keith A, Bellovich, Susan, Steigerwalt, Zeenat, Bhat, Jennifer J, Hawkins, Lalita, Subramanian, Sylvia E, Rosas, John R, Sedor, Miguel A, Vasquez, Sushrut S, Waikar, Markus, Bitzer, Subramaniam, Pennathur, Frank C, Brosius, Ian, De Boer, Min, Chen, Matthias, Kretzler, Wenjun, Ju, Kalyani, Perumal
Publikováno v:
Diabetes. 71:2664-2676
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD). Prognostic biomarkers reflective of underlying molecular mechanisms are critically needed for effective management of DKD. A three-marker panel was derived from a
Autor:
Michelle T. McNulty, Damian Fermin, Felix Eichinger, Dongkeun Jang, Matthias Kretzler, Noël P. Burtt, Martin R. Pollak, Jason Flannick, Astrid Weins, David J. Friedman, Matthew G. Sampson, K. Dell, J. Sedor, M. Schachere, J. Negrey, K. Lemley, B. Silesky, T. Srivastava, A. Garrett, C. Sethna, K. Laurent, P. Canetta, A. Pradhan, L. Greenbaum, C. Wang, C. Kang, S. Adler, J. LaPage, A. Athavale, M. Itteera, M. Atkinson, T. Dell, F. Fervenza, M. Hogan, J. Lieske, V. Chernitskiy, F. Kaskel, M. Ross, P. Flynn, J. Kopp, J. Blake, H. Trachtman, O. Zhdanova, F. Modersitzki, S. Vento, R. Lafayette, K. Mehta, C. Gadegbeku, S. Quinn-Boyle, M. Hladunewich, H. Reich, P. Ling, M. Romano, A. Fornoni, C. Bidot, M. Kretzler, D. Gipson, A. Williams, C. Klida, V. Derebail, K. Gibson, E. Cole, J. Ormond-Foster, L. Holzman, K. Meyers, K. Kallem, A. Swenson, K. Sambandam, Z. Wang, M. Rogers, A. Jefferson, S. Hingorani, K. Tuttle, M. Bray, E. Pao, A. Cooper, J.J. Lin, Stefanie Baker, L. Barisoni, J. Bixler, H. Desmond, S. Eddy, D. Fermin, B. Gillespie, V. Kurtz, M. Larkina, S. Li, C.C. Lienczewski, J. Liu, T. Mainieri, L. Mariani, M. Sampson, A. Smith, J. Zee, Carmen Avila-Casado, Serena Bagnasco, Joseph Gaut, Stephen Hewitt, Jeff Hodgin, Kevin Lemley, Laura Mariani, Matthew Palmer, Avi Rosenberg, Virginie Royal, David Thomas, Jarcy Zee, Laura Barisoni, Cynthia Nast
Publikováno v:
Kidney International. 102:136-148
Apolipoprotein L1 (APOL1)-associated focal segmental glomerulosclerosis (FSGS) is the dominant form of FSGS in Black individuals. There are no targeted therapies for this condition, in part because the molecular mechanisms underlying APOL1's pathogen
Autor:
David J. States, Gilbert S. Omenn, Samir M. Hanash, Chunxia Lu, Ronald A. DePinho, Nabeel Bardeesy, Damian Fermin, Yan Zhang, Qing Zhang, Rajasree Menon
Supplementary Figure 1 from Identification of Novel Alternative Splice Isoforms of Circulating Proteins in a Mouse Model of Human Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03761ea3bbcb2d2f3e35de6fa1096b8e
https://doi.org/10.1158/0008-5472.22377212
https://doi.org/10.1158/0008-5472.22377212