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Publikováno v:
Journal of Cell Science. Apr2023, Vol. 136 Issue 7, p1-2. 2p.
Autor:
Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E. Divine, Jonathan N. Pruneda, Serge Mostowy
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bacteria targeted by
Externí odkaz:
https://doaj.org/article/436bf4795b76401d890df3ba3027711b
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 4, Pp 151359- (2023)
Staphylococcus aureus, a Gram-positive bacterial pathogen, is an urgent health threat causing a wide range of clinical infections. Originally viewed as a strict extracellular pathogen, accumulating evidence has revealed S. aureus to be a facultative
Externí odkaz:
https://doaj.org/article/2a4e19b813af4c758b710d43022eaf83
Autor:
Sydney L. Miles, Vincenzo Torraca, Zoe A. Dyson, Ana Teresa López-Jiménez, Ebenezer Foster-Nyarko, Damián Lobato-Márquez, Claire Jenkins, Kathryn E. Holt, Serge Mostowy
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Enteroinvasive Escherichia coli (EIEC) and Shigella are closely related agents of bacillary dysentery. It is widely viewed that EIEC and Shigella species evolved from E. coli via independent acquisitions of a large virulence plasmid (pINV) e
Externí odkaz:
https://doaj.org/article/c4d043d4f7ee43a1a46f60e1377649ae
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/abf193106edc4c27a6b392ee28887133
Autor:
Damián Lobato-Márquez, Jingwei Xu, Gizem Özbaykal Güler, Adaobi Ojiakor, Martin Pilhofer, Serge Mostowy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Septins are cytoskeletal proteins that assemble into complexes and contribute to immunity by entrapping intracellular bacteria in cage-like structures. Here, Lobato-Márquez et al. reconstitute septin cages in vitro using purified recombinant complex
Externí odkaz:
https://doaj.org/article/7bfe02646c054d8c8ec6e9ed6237ffa9
Autor:
Pamela P. Lee, Damián Lobato-Márquez, Nayani Pramanik, Andrea Sirianni, Vanessa Daza-Cajigal, Elizabeth Rivers, Alessia Cavazza, Gerben Bouma, Dale Moulding, Kjell Hultenby, Lisa S. Westerberg, Michael Hollinshead, Yu-Lung Lau, Siobhan O. Burns, Serge Mostowy, Mona Bajaj-Elliott, Adrian J. Thrasher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflamm
Externí odkaz:
https://doaj.org/article/7f189439f64c4318ac3cf0baaa3c3614
Autor:
Sammy El-Mansi, Christopher L. Robinson, Katja B. Kostelnik, Jessica J. McCormack, Tom P. Mitchell, Damián Lobato-Márquez, Vinothini Rajeeve, Pedro Cutillas, Daniel F. Cutler, Serge Mostowy, Thomas D. Nightingale
Publikováno v:
Blood.
In response to tissue injury, within seconds the ultra-large glycoprotein von Willebrand factor (VWF) is released from endothelial storage organelles (Weibel−Palade bodies) into the lumen of the blood vasculature, where it leads to the recruitment
Autor:
Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E. Divine, Jonathan N. Pruneda, Serge Mostowy
During host cell invasion,Shigellaescapes to the cytosol and polymerizes actin for cell-to-cell spread. To restrict cell-to-cell spread, host cells employ cell-autonomous immune responses including antibacterial autophagy and septin cage entrapment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cc227a07d1008e23f0d46347daefa71
https://doi.org/10.1101/2022.11.14.516380
https://doi.org/10.1101/2022.11.14.516380