Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system.

Autor: Damen MPM; Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Phan TH; Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Ummels R; Department of Medical Microbiology and Infection Control, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, 1081 HV Amsterdam, The Netherlands., Rubio-Canalejas A; Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Bitter W; Department of Medical Microbiology and Infection Control, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, 1081 HV Amsterdam, The Netherlands., Houben ENG; Section Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. Electronic address: e.n.g.houben@vu.nl.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 May 01; Vol. 295 (18), pp. 5960-5969. Date of Electronic Publication: 2020 Mar 17.

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

Autor: Ates LS; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Sayes F; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Frigui W; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Ummels R; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands., Damen MPM; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Bottai D; University of Pisa, Department of Biology, Pisa, Italy., Behr MA; McGill International TB Centre, Infectious Diseases and Immunity in Global Health Program at the McGill University Health Centre Research Institute, Montreal, Canada., van Heijst JWJ; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Bitter W; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands., Majlessi L; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France., Brosch R; Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France.

Publikováno v: PLoS pathogens [PLoS Pathog] 2018 Jun 18; Vol. 14 (6), pp. e1007139. Date of Electronic Publication: 2018 Jun 18 (Print Publication: 2018).