Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Damara Gebauer"'
Autor:
Lars Karlsson, Neelakandha S. Mani, Todd K. Jones, Steven Nguyen, Pragnya J. Desai, Cheryl A. Grice, Kristen L. Arienti, Robin L. Thurmond, Frank U. Axe, James P. Edwards, Mike Randal, Siquan Sun, Danielle K. Wiener, Michael K. Ameriks, Jing Liu, Alice Lee-Dutra, Damara Gebauer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2370-2374
A series of pyrazole-based thioethers were prepared and found to be potent cathepsin S inhibitors. A crystal structure of 13 suggests that the thioether moiety may bind to the S3 pocket of the enzyme. Additional optimization led to the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c34a29a046072b572140132f3755f69
https://doi.org/10.1016/j.bmcl.2010.01.108
https://doi.org/10.1016/j.bmcl.2010.01.108
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:1041-1045
The cleavage and polyadenylation specificity factor (CPSF) complex is required for the cleavage and polyadenylation of the 3'-end of messenger RNA precursors in eukaryotes. During structural studies of the 100 kDa subunit (CPSF-100, Ydh1p) of the yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc651e2bef30bac7856812d5d14b6551
https://doi.org/10.1107/s1744309106038152
https://doi.org/10.1107/s1744309106038152
Autor:
Yang Shen, Liang Tong, Damara Gebauer, Martin Krönke, Jiang Li, Katja Wiegmann, Gerwald Jogl, Hamid Kashkar
Publikováno v:
The EMBO Journal. 21:4785-4795
The BEACH domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. However, it does not share any sequence homology with other proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a52ce9eb54e75adfed9b288226634e
https://doi.org/10.1093/emboj/cdf502
https://doi.org/10.1093/emboj/cdf502
Autor:
Michael K. Ameriks, James P. Edwards, Jian Zhu, Lars Karlsson, Bart L. Staker, Hans E. Purkey, Damara Gebauer, Ingrid C. Choong, Siquan Sun, Robin L. Thurmond, Scott D. Bembenek, Matthew T Burdett, Yin Gu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(14)
A pyridazin-4-one fragment 4 (hCatS IC50 = 170 μM) discovered through Tethering was modeled into cathepsin S and predicted to overlap in S2 with the tetrahydropyridinepyrazole core of a previously disclosed series of CatS inhibitors. This fragment s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0724023e642a3d9c338e4a46b68cbe
https://pubmed.ncbi.nlm.nih.gov/20541404
https://pubmed.ncbi.nlm.nih.gov/20541404
Autor:
Elizabeth Ann Gleason, Lars Karlsson, Hui Cai, Damara Gebauer, James P. Edwards, Yin Gu, Siquan Sun, Michael K. Ameriks, Jian Zhu, Robin L. Thurmond, Steven Nguyen
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
Basic lipophilic substituents dramatically improved the cellular potency of a previously disclosed series of pyrazole-based arylalkyne cathepsin S inhibitors. The incorporation of substituted benzylamines in the para position of the arylalkyne mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1365145a9bdbdafe7d0d09e7a22c246d
https://pubmed.ncbi.nlm.nih.gov/19783435
https://pubmed.ncbi.nlm.nih.gov/19783435
Autor:
Damara Gebauer, Hailong Zhang, Syuzo Kaneko, Liang Tong, Corey R. Mandel, Vasupradha Vethantham, James L. Manley
Publikováno v:
Nature. 444(7121)
The crystal structure of CPSF-73, part of a complex involved in mRNA cleavage and polyadenylation is solved. CPSF-73 was purified and shown to endonucleolytically cleave mRNA, in a reaction mediated by two zinc ligands. Most eukaryotic messenger RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0326f324efa9b5839e28373ec3af1e6d
https://pubmed.ncbi.nlm.nih.gov/17128255
https://pubmed.ncbi.nlm.nih.gov/17128255
Publikováno v:
Biochemistry. 43(47)
The beige and Chediak-Higashi syndrome (BEACH) domain defines a large family of eukaryotic proteins that have diverse cellular functions in vesicle trafficking, membrane dynamics, and receptor signaling. The domain is the only module that is highly c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c815f8dbb348724bb2a4fa3b7c9d0dd8
https://pubmed.ncbi.nlm.nih.gov/15554694
https://pubmed.ncbi.nlm.nih.gov/15554694
Autor:
Rong Qi, Joanne Edington, Bhubaneswar Mishra, David C. Page, Laura G. Brown, Zhongwu Lai, Damara Gebauer, Veronica Gibaja, Lei Ni, Hongjuan Zhao, Thomas Anantharaman, Stephanie Delobette, Richa Saxena, Joseph Giacalone, Yiannis Skiadas, David C. Schwartz
The accurate mapping of clones derived from genomic regions containing complex arrangements of repeated elements presents special problems for DNA sequencers. Recent advances in the automation of optical mapping have enabled us to map a set of 16 BAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa03293dfaed7de6e855683c1459668e
https://europepmc.org/articles/PMC310922/
https://europepmc.org/articles/PMC310922/
Autor:
Brett Porter, Jieyi Lin, Rong Qi, Y. Skiadis, Stephanie Delobette, Joanne Edington, Joseph Giacalone, Catharina Hiort, Thomas Anantharaman, Zhongwu Lai, E. Lee, J. Evenzehav, Christopher Aston, Edward J. Huff, D. C. Schwartz, Eileen T. Dimalanta, Virginia Clarke, Bud Mishra, Damara Gebauer, Junping Jing
Publikováno v:
RECOMB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd1c55c441e13490a54032044be8d9e
https://doi.org/10.1145/279069.279124
https://doi.org/10.1145/279069.279124