In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

Autor: Arnold Donkor Forkuo, Charles Ansah, Kwesi Boadu Mensah, Kofi Annan, Ben Gyan, Anjo Theron, Dalu Mancama, Colin W. Wright

Publikováno v: Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017)

Abstract Background Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication of malaria. The high patronage of the aqueous root extract of the popular West African anti-malarial plant Cryptol

Externí odkaz: https://doaj.org/article/b86bc2e8fefc4e1f9c37785ec7650004

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Autor: Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg

Externí odkaz: https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b

Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes

Autor: Michèle Ramsay, Sibongile Tshabalala, Neil A. Martinson, Natasha Beeton-Kempen, Ananyo Choudhury, Dalu Mancama

Publikováno v: Pharmacogenetics and Genomics

Supplemental Digital Content is available in the text.
Background African populations are characterised by high genetic diversity, which provides opportunities for discovering and elucidating novel variants of clinical importance, especially tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37476c8b6bfc6bccbf6247b7dc947516
https://doi.org/10.1097/fpc.0000000000000380

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite

Autor: Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale

Publikováno v: Journal of medicinal chemistry. 64(4)

A novel diazaspiro[3.4]octane series was identified from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec7cacd693b294b3c6008da32ec3b00e
https://pubmed.ncbi.nlm.nih.gov/33573376

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Autor: Sabine Ottilie, Belinda C. Bezuidenhout, Claire Le Manach, Sonja B Lauterbach, Grant A. Boyle, Dale Taylor, Mariёtte E. van der Watt, James Duffy, Janette Reader, Kelly Chibale, Gregory S. Basarab, Luisa Nardini, David Calvo, Erica Erlank, Theresa L. Coetzer, Dalu Mancama, Nimisha Mittal, Elizabeth A. Winzeler, Phanankosi Moyo, Nelius Venter, Lizette L. Koekemoer, Lyn-Marie Birkholtz, André Horatscheck, Anjo Theron, Ashleigh van Heerden

New chemical matter is needed to target the divergent biology associated with the different life cycle stages ofPlasmodium. Here, we report the parallel screening of the Medicines for Malaria Venture Pandemic Response Box to identify multistage-activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b62554483139943f425434f420265a7
https://doi.org/10.1101/2020.06.05.133405