Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Dallas Boodhoo"'
Autor:
Alexandru Tatomir, Freidrich Anselmo, Dallas Boodhoo, Hegang Chen, Armugam P. Mekala, Vinh Nguyen, Jacob Cuevas, Violeta Rus, Horea Rus
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Regular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable tool for measuring disease activity in multiple sclerosis (MS) if they reflect the patholo
Externí odkaz:
https://doaj.org/article/c1a6b37ddc154eb2b4edd7d48cc60a85
Autor:
Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Jean-Paul Courneya, Dallas Boodhoo, Cornelia Cudrici, Dafin F. Muresanu, Violeta Rus, Tudor C. Badea, Horea Rus
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Response Gene to Complement 32 (RGC-32) is an important mediator of the TGF-β signaling pathway, and an increasing amount of evidence implicates this protein in regulating astrocyte biology. We showed recently that spinal cord astrocytes in mice lac
Externí odkaz:
https://doaj.org/article/6ab4589ccead47d7b05317a5a92110a0
Autor:
Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Dallas Boodhoo, Armugam Mekala, Cornelia Cudrici, Tudor C. Badea, Dafin F. Muresanu, Violeta Rus, Horea Rus
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Astrocytes are increasingly recognized as critical contributors to multiple sclerosis pathogenesis. We have previously shown that lack of Response Gene to Complement 32 (RGC-32) alters astrocyte morphology in the spinal cord at the peak of experiment
Externí odkaz:
https://doaj.org/article/d0ac47c8491a434c82051567eb600e28
Autor:
Alexandru Tatomir, Gautam Rao, Dallas Boodhoo, Sonia I. Vlaicu, Austin Beltrand, Freidrich Anselmo, Violeta Rus, Horea Rus
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with surviving OLGs in multiple sclerosis (MS) plaques, but it is not yet known whether SIRT1 is
Externí odkaz:
https://doaj.org/article/782962ac7e694e6f9da9a252777e91d6
Autor:
Sonia I. Vlaicu, Alexandru Tatomir, Matthew Fosbrink, Vinh Nguyen, Dallas Boodhoo, Cornelia Cudrici, Tudor C. Badea, Violeta Rus, Horea Rus
Publikováno v:
Clinical immunology (Orlando, Fla.). 238
Proliferation of endothelial cells (EC) and smooth muscle cells (SMC) is a critical process in atherosclerosis. Here, we investigated the involvement of sublytic C5b-9 effector Response Gene to Complement 32 (RGC-32) in cell cycle activation, phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed97ac84089e66c0ab3eba285fe399be
https://pubmed.ncbi.nlm.nih.gov/35462050
https://pubmed.ncbi.nlm.nih.gov/35462050
Autor:
Horea Rus, Freidrich Anselmo, Dallas Boodhoo, Austin Beltrand, Violeta Rus, Gautam G. Rao, Alexandru Tatomir, Sonia I. Vlaicu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with surviving OLGs in multiple sclerosis (MS) plaques, but it is not yet known whether SIRT1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f22d386d097d75b182daa2ac60479
http://europepmc.org/articles/PMC7160252
http://europepmc.org/articles/PMC7160252
Autor:
Freidrich Anselmo, Daniel Hewes, Horea Rus, Alexandru Tatomir, Violeta Rus, Dallas Boodhoo, Jonathan Ciriello
Publikováno v:
Experimental and Molecular Pathology. 105:175-180
We have previously shown that SIRT1 mRNA expression was significantly lower in relapsing MS patients compared to those in remission. Our goal was to longitudinally investigate the role of active, phosphorylated SIRT1 (p-SIRT1) as a potential biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9c9028e6588c6cccc2242797821e65
https://doi.org/10.1016/j.yexmp.2018.07.008
https://doi.org/10.1016/j.yexmp.2018.07.008
Autor:
Vinh Nguyen, Dallas Boodhoo, Horea Rus, Cornelia Cudrici, Anamaria Talpos-Caia, Armugam P. Mekala, Alexandru Tatomir, Cosmin Tegla, Tudor C. Badea, Freidrich Anselmo, Adam Sugarman, Violeta Rus, Alvaro Martin
Publikováno v:
Immunologic Research. 66:445-461
Extracellular matrix (ECM) deposition in active demyelinating multiple sclerosis (MS) lesions may impede axonal regeneration and can modify immune reactions. Response gene to complement (RGC)-32 plays an important role in the mediation of TGF-β down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498427a477dea4ca1d7da9daa701e3f5
https://doi.org/10.1007/s12026-018-9011-x
https://doi.org/10.1007/s12026-018-9011-x
Autor:
Armugam P. Mekala, Dallas Boodhoo, Jason R. Lees, Paul A. Antony, Cosmin Tegla, Irina G. Luzina, Vinh Q. Nguyen, Cornelia Cudrici, Alexandru Tatomir, Horea Rus, Tudor C. Badea, Violeta Rus
Publikováno v:
The Journal of Immunology. 198:3869-3877
Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-β tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f08c5baeee227f96c5443eeaf8e433b
https://doi.org/10.4049/jimmunol.1602158
https://doi.org/10.4049/jimmunol.1602158
Autor:
Horea Rus, Freidrich Anselmo, Romeo Ioan Chira, Violeta Rus, Alexandru Tatomir, Sonia I. Vlaicu, Dallas Boodhoo
Publikováno v:
Immunologic research. 67(2-3)
The response gene to complement (RGC)-32 acts as a cell cycle regulator and mediator of TGF-β effects. However, recent studies have revealed other functions for RGC-32 in diverse processes such as cellular migration, differentiation, and fibrosis. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcdad9536996c7bff200a4d4c429655
https://pubmed.ncbi.nlm.nih.gov/31250246
https://pubmed.ncbi.nlm.nih.gov/31250246