Výsledky vyhledávání - "Daljit S. Dhanoa"

Acidic phenols: a new class of potent nonpeptide angiotensin II receptor antagonists

Autor: W.J. Greenlee, Dorothy Levorse, Kenneth J. Fitch, Jim Tata, Peter K. S. Siegl, R. S. L. Chang, Karen Owens, Dooseop Kim, Tsing-Bau Chen, Gloria J. Zingaro, S. Scheck, Daljit S. Dhanoa, Nathan B. Mantlo, Salah D. Kivlighn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:207-212

A series of imidazo[4,5-b]pyridine-based acidic phenols (Table 1,2) and biphenyl ethers (Table 3) are exemplified as novel non-peptide AII receptor antagonists. 0,0′-substituents which affect the acidity of the phenolic portion dramatically impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b4edd3df3b4f383961e4375095d9fa8
https://doi.org/10.1016/s0960-894x(01)81148-3

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Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides

Autor: Scott W. Bagley, Daljit S. Dhanoa, Gloria J. Zingaro, Salah D. Kivlighn, Peter K. S. Siegl, Victor J. Lotti, William J. Greenlee, Raymond S.L. Chang, Tsing B. Chen, Arthur A. Patchett

Publikováno v: Journal of Medicinal Chemistry. 36:4239-4249

The design, synthesis, and biological activity of a new class of highly potent non-peptide AII receptor antagonists derived from N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides which exhibit a high selectivity for the AT1 receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39347debe1b0694fef73874b08aad1
https://doi.org/10.1021/jm00078a014

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Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Autor: William J. Greenlee, Arthur A. Patchett, Salah D. Kivlighn, Raymond S.L. Chang, Peter K. S. Siegl, Tsing B. Chen, Victor J. Lotti, Daljit S. Dhanoa, Scott W. Bagley, Gloria J. Zingaro

Publikováno v: Journal of Medicinal Chemistry. 36:4230-4238

A series of N-acylated indoles (12-18), N-alkylated indoles (19-24), N-acylated dihydroindoles (26-30), and N-alkylated dihydroindoles (31-34) were synthesized and evaluated in the in vitro AT1 (rabbit aorta) and AT2 (rat midbrain) binding assay. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86a91f27a543b6b7b7dcceb6ad1f0be
https://doi.org/10.1021/jm00078a013

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The synthesis of potent marcocyclic renin inhibitors

Autor: Arthur A. Patchett, Daljit S. Dhanoa, William H. Parsons, William J. Greenlee

Publikováno v: Tetrahedron Letters. 33:1725-1728

An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::beb0518d29858a366fe30f807174bbd6
https://doi.org/10.1016/s0040-4039(00)91716-7

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Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites

Autor: J. A. Salon, C. Hou, W. Cui, T A Branchek, Imadul Islam, Yasuchika Yamaguchi, H. Rueger, P. Du, N. Boyle, J. A. Tamm, Y. Shifman, P. J.-J. Vaysse, Daljit S. Dhanoa, Charles Gluchowski, R L Weinshank, Tibur Schmidlin, Mary W. Walker, B. Dowling, N Adham

Publikováno v: Protein engineering. 10(2)

has been discovered (Figure 1b; Rudolf et al., 1994).Neuropeptide Y (NPY) receptors belong to the G-protein- To study the ligand–receptor interactions between the Y1coupled receptor (GPCR) superfamily and mediate several receptor and BIBP3226 Y1 as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d34b339e21b8e945a0709213e726ff
https://pubmed.ncbi.nlm.nih.gov/9089810

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ChemInform Abstract: Synthesis of (+)-Palitantin

Autor: Daljit S. Dhanoa, Lucia Baptistella, Yoji Sakito, Stephen Hanessian

Publikováno v: ChemInform. 21

(-)-Quinic acid was utilized for the synthesis of (+)-palitantin adopting the chiron approach. Pertinent methodology includes stereocontrolled free-radical deoxygenation, functional group adjustments and an α-keto hydroxymethylation reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d31377c05f4b67fe4db566da2fbb766
https://doi.org/10.1002/chin.199009335

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