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pro vyhledávání: '"Daljinder K. Woloch"'
Autor:
Daljinder K. Woloch, Jetze J. Tepe, Jason S. Fisk, Michael R. Kuszpit, Lauren M. Azevedo, Dillon P. Cogan, Jacob R. Ludwig, Theresa A. Lansdell, Gregory P. Patten, Robert A. Mosey
Publikováno v:
Journal of Medicinal Chemistry. 56:5974-5978
The proteasome has emerged as the primary target for the treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type proteasome inhibitors, such as bortezomib. Herein, we describe the optimization of non-c