Výsledky vyhledávání - "Dalit Tchorsh-Yutsis"

Embryonic Pig Pancreatic Tissue for the Treatment of Diabetes: Potential Role of Immune Suppression With 'Off-the-Shelf' Third-Party Regulatory T Cells

Autor: Lior Zangi, Rivka Bitcover, Yael Zlotnikov Klionsky, Elias Shezen, Anna Aronovich, Orna Tal, Helena Katchman, Esther Bachar-Lustig, Smadar Eventov-Friedman, Ilan Feine, Chava Rosen, Dalit Tchorsh-Yutsis, Sivan Cohen, Yair Reisner

Publikováno v: Transplantation. 91:398-405

Background. Xenogeneic embryonic pancreatic tissue can provide an attractive alternative for organ replacement therapy. However, immunological rejection represents a major obstacle. This study examines the potential of regulatory T cells (Tregs) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce25d1105d8f0d527854787364ce422
https://doi.org/10.1097/tp.0b013e318204be15

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Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes

Autor: Anna Aronovich, Hideo Yagita, Yair Reisner, Rivka Bitcover, Helena Katchman, Oren Milstein, Orna Tal, Smadar Eventov-Friedman, Chava Rosen, Elias Shezen, Gil Hecht, Bruce R. Blazar, Sivan Cohen, Yael Zlotnikov Klionsky, Dalit Tchorsh-Yutsis

Publikováno v: Diabetes. 58:1585-1594

OBJECTIVEDefining an optimal costimulatory blockade–based immune suppression protocol enabling engraftment and functional development of E42 pig embryonic pancreatic tissue in mice.RESEARCH DESIGN AND METHODSConsidering that anti-CD40L was found to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00bf49c8711bd8cdbcfbcc151b9dad1c
https://doi.org/10.2337/db09-0112

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A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure

Autor: Irit Milman, Uriel Martinowitz, Gidi Rechavi, David Hagin, Liran Yarimi, Takashi Nagasawa, Chava Rosen, Yaniv Nur, Yael Zlotnikov Klionsky, Anna Aronovich, Yair Reisner, Dalit Tchorsh-Yutsis, Paul S. Frenette, Elias Shezen

Analysis of hematopoietic stem cells (HSCs) in factor VIII knockout (FVIIIKO) mice revealed a novel regulatory role for the coagulation cascade in hematopoiesis. Thus, HSCs in FVIIIKO mice had reduced proportions of CD34(low) cells within Lin(-)Sca(+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7839144de10a3ce9b450bf5acec97f
https://europepmc.org/articles/PMC5527398/

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Growth enhancement by embryonic fibroblasts upon cotransplantation of noncommitted pig embryonic tissues with fully committed organs

Autor: Elias Shezen, Smadar Eventov-Friedman, Sivan Cohen, Anna Aronovich, Helena Katchman, Dalit Tchorsh-Yutsis, Yair Reisner, Yael Zlotnikov Klionsky, Orna Tal

Publikováno v: Transplantation. 89(10)

BACKGROUND We recently defined the optimal gestational time windows for the transplantation of several embryonic tissues. We showed that the liver and kidney obtained from E28 pig embryos can grow and differentiate normally after transplantation, whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031bde80d14eb9fa5f62fa68f2a1910a
https://pubmed.ncbi.nlm.nih.gov/20195218

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Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression

Autor: Dalit, Tchorsh-Yutsis, Gil, Hecht, Anna, Aronovich, Elias, Shezen, Yael, Klionsky, Chava, Rosen, Rivka, Bitcover, Smadar, Eventov-Friedman, Helena, Katchman, Sivan, Cohen, Orna, Tal, Oren, Milstein, Hideo, Yagita, Bruce R, Blazar, Yair, Reisner

Publikováno v: Diabetes

OBJECTIVE Defining an optimal costimulatory blockade–based immune suppression protocol enabling engraftment and functional development of E42 pig embryonic pancreatic tissue in mice. RESEARCH DESIGN AND METHODS Considering that anti-CD40L was found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5b2e4082fe40a99b06066f671cc44c9
https://pubmed.ncbi.nlm.nih.gov/19401429

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Hematopoietic Size Control: A Novel Role for Factor VIII Via the Thrombin/PAR1 Axis in Regulating the Interplay Between Dynamic Bone Structure and Long Term Survival and Mobilization of Hematopoietic Stem Cells

Autor: Gideon Rechavi, Liran Yarimi, Yair Reisner, Uriel Martinowitz, Anna Aronovich, Yaniv Nur, Dalit Tchorsh–Yutsis, Yael Zlotnikov Klionsky, David Hagin, Chava Rosen

Publikováno v: Blood. 118:19-19

Abstract 19 Despite great progress in embryogenesis, the underlying mechanism that controls tissues and organs size remains a mystery. We previously showed that transplanted pig embryonic tissues are markedly enlarged in Factor VIII knockout (F8KO) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73a00eaa704232851cd1af51adb93fda
https://doi.org/10.1182/blood.v118.21.19.19

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Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning

Autor: Eran Ophir, Esther Bachar-Lustig, Noga Or-Geva, Dalit Tchorsh-Yutsis, Yair Reisner, Yael Zlotnikov Klionsky

Publikováno v: Blood. 116:3726-3726

Abstract 3726 Induction of specific durable immune tolerance towards transplanted donor cells and tissues, without chronic administration of toxic immunosuppressive drugs, represents a most desirable goal in transplantation medicine. Two major approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6281ef37bd230d0c446c8e580cd1f567
https://doi.org/10.1182/blood.v116.21.3726.3726

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