Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe‐Dnmts axis

Autor: Vladislav Strmiska, Petr Michalek, Zuzana Lackova, Roman Guran, Sona Krizkova, Lucie Vanickova, Ondrej Zitka, Marie Stiborova, Tomas Eckschlager, Borivoj Klejdus, Dalibor Pacik, Eliska Tvrdikova, Claudia Keil, Hajo Haase, Vojtech Adam, Zbynek Heger

Publikováno v: Molecular Oncology, Vol 13, Iss 5, Pp 1002-1017 (2019)

DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells while decreasing their doubli

Externí odkaz: https://doaj.org/article/04f0e5a202ed485ea5b906c03279d789

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer.

Autor: Zbynek Heger, Miguel Angel Merlos Rodrigo, Petr Michalek, Hana Polanska, Michal Masarik, Vitezslav Vit, Mariana Plevova, Dalibor Pacik, Tomas Eckschlager, Marie Stiborova, Vojtech Adam

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165830 (2016)

The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent LNCaP) with sarcosine stimulate

Externí odkaz: https://doaj.org/article/e0dd4ea7f85c43e08a03d6591ff42422

Contents Vol. 92, 2014

Autor: Juan Francisco Hermida Gutiérrez, Ho Song Yu, Cui-Yun Tian, Jie Li, Folin Liu, Sun-Ouck Kim, Praful Ravi, C. Andreoni, Oliver W. Hakenberg, Christian Uprimny, Stefan Zastrow, Dalibor Pacik, Feng Wang, Piotr Milecki, Qiang Lv, Nobuo Tsuru, Jia Li, Taek Won Kang, Massimo Madonia, Chunxi Wang, Satz Mengensatzproduktion, Evangelos Liatsikos, Rahul Janak Sinha, Yuanhu Yuan, Giorgio Gandaglia, Zoltan Bajory, Murat Kosan, Shohei Tobu, Qian Zhang, Dong Deuk Kwon, Silke Gillessen, Jesús Moreno Sierra, V. Ortiz, Ken-ichi Mori, Xiaoning Wang, Qiang Cao, Heng-Qing An, Jinghai Hu, Zhe Tian, Nianzeng Xing, Roland Dahlem, Luis Ortega Medina, Yuting Wu, Quoc-Dien Trinh, Vincenzo Favilla, Luis A. Kluth, Yan Wang, Jun Yang, In Sang Hwang, Gengqing Wu, Wahid Tantawy, Giorgio Ivan Russo, Massimiliano Veroux, Dazhi Long, Vladimir Novotny, Ben Xu, Andreas Becker, Mohammad Mohseni, Jiro Uozumi, Richard Cathomas, Pu Li, Eu Chang Hwang, Rudolf Wolfgang Gasser, Tommaso Castelli, Rihai Xiao, Stavros Kontogiannis, Seyed Reza Hosseini, Alexander Fesenko, Maxine Sun, Hakan Ozkardes, Xiaoqing Wang, Panagiotis Kallidonis, Tufan Cicek, Hannes Steiner, Pierre I. Karakiewicz, Martin Hatzinger, Markus Graefen, Ignacio T. Castillón Vela, Krzystof Lesniewski-Kmak, Serdar Goktas, Xiaobing Ju, Abdulrahman Al-Aown, Changjun Yin, Frederico Goncalves, Yukio Homma, Florian Roghmann, Guoxi Zhang, Gabriel Kacso, Giuseppe Morgia, Ji Lu, Mitsuru Noguchi, Haruki Kume, Farshid Alizadeh, Gökçen Çoban, Iason Kyriazis, Chao Qin, Dheeraj Kumar Gupta, Immanuel von Bar, Maria Eugenia León Rueda, Hiroyuki Ihara, Joachim Noldus, Xiaoxin Meng, Hui Xu, Thorsten Schlomm, Yijun Xue, Mohit Pandey, Yu-Jie Wang, Ahmed El Ghoneimy, Xiaofeng Zou, Anh Phuong, Giuseppe Sortino, Umut Gonulalan, Gero Kramer, Michael Sohn, Qihui Chen, Ioannis Georgiopoulos, Jie Jin, Yanbo Wang, Pengfei Shao, Min Liu, Mounira Bouzid, Murat Akand, Renate Pichler, Zhihua Lu, Isabel Heidegger, Toru Sugihara, Alexander Kroiss, Druckerei Stückle, Javier Casado Varela, Manabu Matsuo, Junhui Zhang, Fengming Jiang, R.K. Krebs, Jianzhong Zhang, Georg Schäfer, Alberto Saita, Yuchuan Hou, Sebastiano Cimino, Vishwajeet Singh, Gerald Klinglmair, Manfred P. Wirth, Jens-Uwe Stolzenburg

Publikováno v: Urologia Internationalis. 92:I-VI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa05c7419b363d521fa23b2e02733a9
https://doi.org/10.1159/000363542

Estrogens and aspects of prostate disease

Autor: Helmut Klocker, Dalibor Pacik, Domenico Prezioso, Kurt G. Naber, Mario Reis, Keith Griffiths, Bernard Lobel, Louis J. Denis, Alexandria Sciarra

Publikováno v: International Journal of Urology. 14:1-16

Estrogens have long been associated with the processes involved in prostate carcinogenesis, particularly in cancer suppression. However, the synergistic influence of low concentrations of estrogens, together with androgens, in promoting aberrant grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::768e1392e2313ae8f0a42cb7c7267d05
https://doi.org/10.1111/j.1442-2042.2006.01476.x

Diagnosis of prostate cancer

Autor: Jehonathan H, Pinthus, Dalibor, Pacik, Jacob, Ramon

Publikováno v: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 175

The contemporary challenge of prostate cancer diagnosis has been changed in the past decade from the endeavor to increase detection to that of detecting only those tumors that are clinically significant. Better interpretation of the role of prostate-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b875a0306fcc28df4b81da2dcbdc995
https://pubmed.ncbi.nlm.nih.gov/17432555