Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Dalian Ding"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Blast wave exposure, a leading cause of hearing loss and balance dysfunction among military personnel, arises primarily from direct mechanical damage to the mechanosensory hair cells and supporting structures or indirectly through excessive
Externí odkaz:
https://doaj.org/article/f0a96ac11a5b446b9e2ad72ee9d33d32
Autor:
Ghjuvan'Ghjacumu Shackleford, Leandro N Marziali, Yo Sasaki, Anke Claessens, Cinzia Ferri, Nadav I Weinstock, Alexander M Rossor, Nicholas J Silvestri, Emma R Wilson, Edward Hurley, Grahame J Kidd, Senthilvelan Manohar, Dalian Ding, Richard J Salvi, M Laura Feltri, Maurizio D'Antonio, Lawrence Wrabetz
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010477 (2022)
Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly, defects in myelination or myelin maintenance lead to secondary axonal damage and subsequent degeneration. Studies utilizing genetic (CNPase-, MAG-, and PLP-null
Externí odkaz:
https://doaj.org/article/3727869bf2534264a552e58bc6edf603
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hearing impairment is a cardinal feature of Down syndrome (DS), but its clinical manifestations have been attributed to multiple factors. Murine models could provide mechanistic insights on various causes of hearing loss in DS. To investigate mechani
Externí odkaz:
https://doaj.org/article/775fe0127b654807a470ff617fc72d58
Autor:
Senthilvelan Manohar, Guang-Di Chen, Dalian Ding, Lijie Liu, Jian Wang, Yu-Chen Chen, Lin Chen, Richard Salvi
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
Noise-induced hearing loss (NIHL), caused by direct damage to the cochlea, reduces the flow of auditory information to the central nervous system, depriving higher order structures, such as the hippocampus with vital sensory information needed to car
Externí odkaz:
https://doaj.org/article/11ca1c467da340bfa8f24f88b76d5811
Autor:
Yue Yu, Jun Huang, Xuehui Tang, Jerome Allison, David Sandlin, Dalian Ding, Yi Pang, Chunming Zhang, Tianwen Chen, Nathan Yin, Lan Chen, William Mustain, Wu Zhou, Hong Zhu
Publikováno v:
Journal of Otology, Vol 15, Iss 3, Pp 77-85 (2020)
The ears are air-filled structures that are directly impacted during blast exposure. In addition to hearing loss and tinnitus, blast victims often complain of vertigo, dizziness and unsteady posture, suggesting that blast exposure induces damage to t
Externí odkaz:
https://doaj.org/article/e613b383ba254381bfd9ceb5e09eea0e
Autor:
Dalian Ding, Jianghui Zhang, Fang Liu, Peng Li, Weidong Qi, Yazhi Xing, Haibo Shi, Haiyan Jiang, Hong Sun, Shankai Yin, Richard Salvi
Publikováno v:
Journal of Otology, Vol 15, Iss 1, Pp 36-40 (2020)
The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However, little is known about fighting oxidat
Externí odkaz:
https://doaj.org/article/20fb8dbe0abd460ab8739860160324ba
Autor:
Hyo-Jin Park, Mi-Jung Kim, Christina Rothenberger, Ashok Kumar, Edith M. Sampson, Dalian Ding, Chul Han, Karessa White, Kevin Boyd, Senthilvelan Manohar, Yong-Hwan Kim, Maria S. Ticsa, Aaron S. Gomez, Isabela Caicedo, Upal Bose, Paul J. Linser, Takuya Miyakawa, Masaru Tanokura, Thomas C. Foster, Richard Salvi, Shinichi Someya
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).
Externí odkaz:
https://doaj.org/article/a4b9d8b940ff4c42bbb2c14bdd319a1a
Autor:
Dalian Ding, Haiyan Jiang, Senthilvelan Manohar, Xiaopeng Liu, Li Li, Guang-Di Chen, Richard Salvi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss
Externí odkaz:
https://doaj.org/article/5630d4e5b7dc49d89ae5af957b8acc13
Autor:
Dalian Ding, Haiyan Jiang, Jianhui Zhang, Xianrong Xu, Weidong Qi, Haibo Shi, Shankai Yin, Richard Salvi
Publikováno v:
Journal of Otology, Vol 13, Iss 4, Pp 115-121 (2018)
Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-respon
Externí odkaz:
https://doaj.org/article/34b544fbda0a47deac79e356a951c380
Autor:
Kaitlyn R. Calabro, Sanford L. Boye, Shreyasi Choudhury, Diego Fajardo, James J. Peterson, Wei Li, Sean M. Crosson, Mi-Jung Kim, Dalian Ding, Richard Salvi, Shinichi Someya, Shannon E. Boye
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Usher’s syndrome is the most common combined blindness–deafness disorder with USH1B, caused by mutations in MYO7A, resulting in the most severe phenotype. The existence of numerous, naturally occurring shaker1 mice harboring variable MYO7A mutati
Externí odkaz:
https://doaj.org/article/8c3c907278374492bd371de6e22e0688