Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Dalia M. Araujo"'
Autor:
Paul A. Lapchak, Dalia M. Araujo
Publikováno v:
Expert Opinion on Emerging Drugs. 12:97-112
Thrombolysis with intravenous alteplase (recombinant tissue-type plasminogen activator) continues to be the sole recourse for acute ischemic stroke therapy, provided that patients seek treatment preferably within 3 h of stroke onset. The narrow windo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7b7db09c5b41c90b30aae91a234575
https://doi.org/10.1517/14728214.12.1.97
https://doi.org/10.1517/14728214.12.1.97
Publikováno v:
Experimental Neurology. 185:154-159
Tenecteplase (TNK) was engineered to have increased fibrin specificity and an increased half-life compared to Alteplase. Although Tenecteplase is currently being tested in a Phase II clinical trial in acute ischemic stroke patients, little is known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0a9c4bc5fdd7715704d8d17a216ad0
https://doi.org/10.1016/j.expneurol.2003.09.009
https://doi.org/10.1016/j.expneurol.2003.09.009
Autor:
Dalia M. Araujo, Paul A. Lapchak
Publikováno v:
American Journal of Cardiovascular Drugs. 3:87-94
The only drug approved by the US FDA for use in patients with acute ischemic stroke is the thrombolytic, alteplase. Whereas alteplase rapidly restores blood flow, the drug has to be administered within 6 hours after symptom onset and is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc38416ba7c490e31ad051a599591f2
https://doi.org/10.2165/00129784-200303020-00002
https://doi.org/10.2165/00129784-200303020-00002
Publikováno v:
Brain Research. 959:183-190
Caspase inhibition has been proposed as a target to attenuate ischemia-induced neurodegeneration and behavioral dysfunction. The present study evaluated the pharmacological effects of a single dose of an irreversible cell permeant general (nonselecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491d8f1d0e4325b2d2d58f75d43b81c3
https://doi.org/10.1016/s0006-8993(02)03739-3
https://doi.org/10.1016/s0006-8993(02)03739-3
Publikováno v:
Stroke. 33:1411-1415
Background and Purpose — It has been proposed that the novel spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N -oxide (NXY-059) may be useful in the treatment of ischemic stroke. However, there is little information concer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05de30dfe8ee4a595b344ab839454d05
https://doi.org/10.1161/01.str.0000015346.00054.8b
https://doi.org/10.1161/01.str.0000015346.00054.8b
Autor:
Dalia M. Araujo, Paul A. Lapchak
Publikováno v:
CNS Drugs. 15:819-829
Thrombolysis with alteplase (recombinant tissue plasminogen activator; rtPA) has proven to be beneficial for acute stroke management, despite the narrow window of opportunity for treatment and the increased risk of haemorrhage. Because of the latter,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53619d0c2e25216bb46ff7868aec807d
https://doi.org/10.2165/00023210-200115110-00001
https://doi.org/10.2165/00023210-200115110-00001
Publikováno v:
Neuroscience. 101:811-814
Prosaposin is a 517 amino acid membrane component and secreted protein 5. , 7. , 9. that is proteolytically cleaved to generate the four small glycoproteins; saposins A, B, C and D. 9. , 13. , 19. Prosaposin’s ability to promote neurite outgrowth 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ab503099deba6a2d605ab90b4870b8
https://doi.org/10.1016/s0306-4522(00)00466-8
https://doi.org/10.1016/s0306-4522(00)00466-8
Autor:
Dalia M. Araujo, Alexander J. Annala, Simon R. Cherry, Keith J. Tatsukawa, Harley I. Kornblum, Michael E. Phelps
Publikováno v:
Nature Biotechnology. 18:655-660
The study of neural repair and neuroplasticity in rodents would be enhanced by the ability to assess neuronal function in vivo. Positron emission tomography (PET) is used to study brain plasticity in humans, but the limited resolution and sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d9055c76f59f45a6d4b3f4ded15f17
https://doi.org/10.1038/76509
https://doi.org/10.1038/76509
Autor:
Dalia M. Araujo, Ai Yi, Yasuyuki Miyoshi, Don M. Gash, Dana Hilt, Shoushu Jiao, F Collin, Zhiming Zhang, Paul A. Lapchak
Publikováno v:
Brain Research. 789:9-22
The present study determined the topographical distribution profile for [125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned (unilateral intracarotid injection) rhesus monkeys following an intraventricular injection. Aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c88350fcf1bcfa08e98ef177d92050f
https://doi.org/10.1016/s0006-8993(97)01495-9
https://doi.org/10.1016/s0006-8993(97)01495-9
Publikováno v:
Brain Research. 777:153-160
A recombinant adenoviral vector encoding the human glial cell line-derived neurotrophic factor (GDNF) gene (Ad-GDNF) was used to express the neurotrophic factor GDNF in the unilaterally 6-hydroxydopamine (6-OHDA) denervated substantia nigra (SN) of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df4c96d3b473466b227fac4f8cc5222
https://doi.org/10.1016/s0006-8993(97)01100-1
https://doi.org/10.1016/s0006-8993(97)01100-1