Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dalia Barkley"'
Autor:
Gustavo S. França, Maayan Baron, Maayan Pour, Benjamin R. King, Anjali Rao, Selim Misirlioglu, Dalia Barkley, Igor Dolgalev, Kwan Ho-Tang, Gal Avital, Felicia Kuperwaser, Ayushi Patel, Douglas A. Levine, Timothee Lionnet, Itai Yanai
Advancements in rational drug design over the past decades have consistently produced new cancer therapies, but such treatments are inevitably countered through an adaptive process that fosters therapy resistance. Malignant cells achieve drug resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8e76627cabae11568a1bcb87b2d339
https://doi.org/10.1101/2022.06.21.496830
https://doi.org/10.1101/2022.06.21.496830
Autor:
Joseph C. Devlin, Dalia Barkley, Florian Wagner, Cristina H. Hajdu, Reuben Moncada, Maayan Baron, Itai Yanai, Diane M. Simeone, Marta Chiodin
Publikováno v:
Nature Biotechnology. 38:333-342
Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell populations in a tissue, but characterizing their spatial organization remains challenging. We combine a microarray-based spatial transcriptomics method that reveals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae79029da72e45c87cfb74ce594c42b2
https://doi.org/10.1038/s41587-019-0392-8
https://doi.org/10.1038/s41587-019-0392-8
Autor:
Dalia Barkley, Reuben Moncada, Maayan Pour, Deborah A. Liberman, Ian Dryg, Gregor Werba, Wei Wang, Maayan Baron, Anjali Rao, Bo Xia, Gustavo S. França, Alejandro Weil, Deborah F. Delair, Cristina Hajdu, Amanda W. Lund, Iman Osman, Itai Yanai
While genetic tumor heterogeneity has long been recognized, recent work has revealed significant variation among cancer cells at the epigenetic and transcriptional levels. Profiling tumors at the single-cell level in individual cancer types has shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b0517bd27c75794c38c7131743e486
https://doi.org/10.1101/2021.12.20.473565
https://doi.org/10.1101/2021.12.20.473565
Publikováno v:
Genome research. 31(10)
Phenotypic heterogeneity within malignant cells of a tumor is emerging as a key property of tumorigenesis. Recent work using single-cell transcriptomics has led to the identification of distinct cancer cell states across a range of cancer types, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a897d61491a15face0e1a5a716454ed
https://pubmed.ncbi.nlm.nih.gov/34599005
https://pubmed.ncbi.nlm.nih.gov/34599005
Publikováno v:
Nature
Deciphering the principles and mechanisms by which gene activity orchestrates complex cellular arrangements in multicellular organisms has far-reaching implications for research in the life sciences. Recent technological advances in next-generation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ec9cef1651c2dff414c8ad79325fc4
https://europepmc.org/articles/PMC8475179/
https://europepmc.org/articles/PMC8475179/
Publikováno v:
Cancer Research. 82:1600-1600
Interferon-gamma (IFNγ) is a canonical proinflammatory cytokine that has well-studied antitumor functions such as the upregulation of MHC Class I (MHC-I), increased Th1 development, macrophage activity, innate immune cell recruitment, and in tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faf7440f269ca41c50bbb295e146cecb
https://doi.org/10.1158/1538-7445.am2022-1600
https://doi.org/10.1158/1538-7445.am2022-1600
Single-cell RNA-Seq measurements are commonly affected by high levels of technical noise, posing challenges for data analysis and visualization. A diverse array of methods has been proposed to computationally remove noise by sharing information acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea60eee53720d9ab2a5690173dafbc30
https://doi.org/10.1101/655365
https://doi.org/10.1101/655365
Autor:
Yun Yan, Bo Xia, Sang Yong Kim, Maayan Baron, Marta Chiodin, Florian Wagner, David L. Keefe, Dalia Barkley, Itai Yanai, Joseph P. Alukal, Jef D. Boeke
Publikováno v:
Cell
The testis expresses the largest number of genes of any mammalian organ, a finding that has long puzzled molecular biologists. Analyzing our single-cell transcriptomic maps of human and mouse spermatogenesis, we provide evidence that this widespread
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39ad04fe4e7a154404f18f89bb3a0a5
https://pubmed.ncbi.nlm.nih.gov/31978338
https://pubmed.ncbi.nlm.nih.gov/31978338
Autor:
Joseph C. Devlin, Marta Chiodin, Diane M. Simeone, Maayan Baron, Reuben Moncada, Cristina H. Hajdu, Florian Wagner, Itai Yanai, Dalia Barkley
Publikováno v:
Nature Biotechnology. 38:1476-1476
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2400bdad2bca04233e3ec347ef9a56
https://doi.org/10.1038/s41587-020-00776-5
https://doi.org/10.1038/s41587-020-00776-5
Autor:
Dalia Barkley, Itai Yanai
Publikováno v:
Trends in Cancer. 5:655-656
While intratumoral heterogeneity has been extensively studied in terms of genetic alterations and phenotypic properties such as drug resistance, only recently has single-cell RNA-seq begun to expose the remarkable transcriptional diversity within tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e1a77396dd1909d0e402e47ba5f63b
https://doi.org/10.1016/j.trecan.2019.09.002
https://doi.org/10.1016/j.trecan.2019.09.002