Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Daleum Nam"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4324-4336 (2024)
Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic processes, and neurotransmitter levels. Leucine-rich repeat kinase 2 (LRRK2) is associated with the
Externí odkaz:
https://doaj.org/article/486c66daa0e54dc99c091cb975b46bdb
Autor:
Daleum Nam, Ami Kim, Sun Jung Han, Sung-Ik Lee, Sung-Hye Park, Wongi Seol, Ilhong Son, Dong Hwan Ho
Publikováno v:
Animal Cells and Systems, Vol 25, Iss 1, Pp 28-36 (2021)
Research on Parkinson’s disease (PD) has been focused on the development of PD diagnostic tools as much as the development of PD therapeutics. Several genetic culprits of PD, including DJ-1, Leucine-rich repeat kinase 2 (LRRK2), and α-synuclein (
Externí odkaz:
https://doaj.org/article/c3461cdab30c4d8c957e3011100640b4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2132 (2023)
α-Synuclein (αSyn) is an important player in Parkinson’s disease (PD) pathogenesis. The aggregation of αSyn is mainly formed in the cytoplasm, whereas some αSyn accumulation has also been found in the nuclei of neurons. To assess the effect of
Externí odkaz:
https://doaj.org/article/72b3a2c50e6f47019861ed7ddcd4d055
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105349- (2021)
Alpha-synuclein (αSyn) is a major component of Lewy bodies, which are a known pathogenic marker of Parkinson's disease (PD). The dysfunction of protein degradation machinery causes αSyn accumulation. The reinforcement of αSyn degradation is a pote
Externí odkaz:
https://doaj.org/article/9c7772b717c54bc1ba91bc855cc3386b
Publikováno v:
Cells, Vol 11, Iss 5, p 861 (2022)
Evidence suggests that crosstalk occurs between microglial leucine-rich repeat kinase 2 (LRRK2)—a regulator of neuroinflammation—and neuron-released α-synuclein (αSyn)—a promoter of microglial activation and neuroinflammatory responses—in n
Externí odkaz:
https://doaj.org/article/ad893a6a11b54c1791b6970305e85286
Autor:
Jihoon Jang, Hakjin Oh, Daleum Nam, Wongi Seol, Mi Kyoung Seo, Sung Woo Park, Hyung Gun Kim, Hyemyung Seo, Ilhong Son, Dong Hwan Ho
Publikováno v:
Animal Cells and Systems, Vol 22, Iss 5, Pp 273-280 (2018)
Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson’s disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis, mitochondrial damage, and nucleolar disruption via up-regulated LRRK2 kinase activity, and th
Externí odkaz:
https://doaj.org/article/9feb4789e01948629aca6824ea330f2e
Publikováno v:
Animal Cells and Systems, Vol 22, Iss 2, Pp 140-147 (2018)
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Although most PD cases are sporadic, 5–10% of them are hereditary and several pathogenic mutations in related genes have been identified. Mutations in TMEM230 were rece
Externí odkaz:
https://doaj.org/article/de85f2ad140644b78524c66df7f174b4
Autor:
Seo-Young Lee, Yeojin Bang, Wongi Seol, Janghwan Kim, Hye-Jung Kim, Hyuna Sim, Mi Kyoung Seo, Hyun Jin Choi, Ilhong Son, Sun-Ku Chung, Juhee Lim, Joo-Eun Lee, Daleum Nam, Sung Woo Park
Publikováno v:
Experimental Neurobiology
Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of familial Parkinson’s disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic G2019S mutation is important for PD development. Several
Publikováno v:
Journal of Parkinson's Disease. 10:981-991
Background α-Synuclein (α-syn) is a major component of Lewy bodies, a pathologic marker of Parkinson's disease (PD) in post-mortem studies. The use of α-syn as a practical PD biomarker has been investigated by numerous researchers. However, report
Publikováno v:
Neurobiology of Disease, Vol 154, Iss, Pp 105349-(2021)
Alpha-synuclein (αSyn) is a major component of Lewy bodies, which are a known pathogenic marker of Parkinson's disease (PD). The dysfunction of protein degradation machinery causes αSyn accumulation. The reinforcement of αSyn degradation is a pote