Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Dale W Prebble"'
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Akademický článek
Cheminformatics-Guided Exploration of Synthetic Marine Natural Product-Inspired Brominated Indole-3-Glyoxylamides and Their Potentials for Drug Discovery
Autor: Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Publikováno v: Molecules, Vol 29, Iss 15, p 3648 (2024)
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a
Externí odkaz: https://doaj.org/article/f89cc53b0fe941b8a953a64e5fcc6f23
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2
Akademický článek
α-synuclein aggregation inhibitory activity of the bromotyrosine derivatives aerothionin and aerophobin-2 from the subtropical marine sponge Aplysinella sp
Autor: Dale W. Prebble, Safak Er, Mingming Xu, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100472- (2022)
The neuronal protein α-synuclein (α-syn) is one of the main constituents of intracellular amyloid aggregations found in the post-mortem brains of Parkinson’s disease (PD) patients. Recently, we screened the MeOH extracts obtained from 300 sub-tro
Externí odkaz: https://doaj.org/article/ebdbe234d624481a967c223a4a7ebfda
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3
Akademický článek
Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia
Autor: Dale W. Prebble, Tanja M. Voser, Safak Er, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100302- (2022)
During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract res
Externí odkaz: https://doaj.org/article/d9b1edf9ef4c4f8cb9d92ed987c40d02
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6
Sycosterol A, an α-Synuclein Inhibitory Sterol from the Australian Ascidian Sycozoa cerebriformis
Autor: George D. Mellick, Mingming Xu, Dale W Prebble, Anthony R. Carroll
Publikováno v: Journal of Natural Products. 84:3039-3043
During a recent biodiscovery study to identify new α-synuclein (α-syn) aggregation inhibitors, we screened 29 Australian marine sponge and ascidian extracts in an MS binding assay. This resulted in an extract from the ascidian Sycozoa cerebriformis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::251bf081018e751ae238c5d59c252a64
https://doi.org/10.1021/acs.jnatprod.1c00768
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7
Anti-prion and α-Synuclein Aggregation Inhibitory Sterols from the Sponge Lamellodysidea cf. chlorea
Autor: Dale W Prebble, Mingming Xu, Merrick Ekins, Alan L. Munn, Anthony R. Carroll, George D. Mellick, Laurence K. Jennings
Publikováno v: Journal of Natural Products. 83:3751-3757
In a study aimed at identifying new anti-prion compounds we screened a library of 500 Australian marine invertebrate derived extracts using a yeast-based anti-prion assay. This resulted in an extract from the subtropical sponge Lamellodysidea cf. chl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65b91129de881a39008c9daccd72b01d
https://doi.org/10.1021/acs.jnatprod.0c01168
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8
Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra
Autor: Vicky M. Avery, Anthony R. Carroll, Luke P. Robertson, Dale W Prebble, Darren C. Holland
Publikováno v: Organic Letters. 22:9574-9578
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra. Based on the combination of MS and NMR analyses and comparison of experimental and TDDFT c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9276f2bd6d0a87864b61a00cdc6b81ea
https://doi.org/10.1021/acs.orglett.0c03633
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9
α-Synuclein Aggregation Inhibitory Prunolides and a Dibrominated β-Carboline Sulfamate from the Ascidian Synoicum prunum
Autor: Darren C. Holland, Dale W. Prebble, Safak Er, Joshua B. Hayton, Luke P. Robertson, Vicky M. Avery, Andrii Domanskyi, Milton J. Kiefel, John N. A. Hooper, Anthony R. Carroll
Seven new polyaromatic bis-spiroketal-containing butenolides, the prunolides D–I (4–9) and cis-prunolide C (10), a new dibrominated β-carboline sulfamate named pityriacitrin C (11), alongside the known prunolides A–C (1–3) were isolated from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681d6824f5e2603fe128de32b2198532
http://hdl.handle.net/10138/353211
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