Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Dale S Haines"'
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Akademický článek
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms
Autor: Amanda St. Paul, Cali Corbett, Amanda Peluzzo, Sheri Kelemen, Rachael Okune, Dale S. Haines, Kyle Preston, Satoru Eguchi, Michael V. Autieri
Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112381- (2023)
Summary: Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key protein linking cytoskeletal dynamics with mRNA stability. RNA immunoprecipitation
Externí odkaz: https://doaj.org/article/4fd4fa7aa58e419bb09041004744973a
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4
Supplementary Figures 1 - 9 from Oncogenic Protein MTBP Interacts with MYC to Promote Tumorigenesis
Autor: Christine M. Eischen, Hua Xiao, Dale S. Haines, Stephen L. Beauparlant, Xi Chen, Maria Pia Arrate, Mark W. Gramling, Brian C. Grieb
PDF file - 687KB, Supplemental Figures S1-S9. S1 shows MTBP induces proliferation. S2 shows peptides in TIP48 and TIP49 identified by mass spectrometry. S3 shows Mtbp increases the pro-proliferative and transforming functions of Myc. S4 shows increas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c22d6d451b385490656748cb0027e98
https://doi.org/10.1158/0008-5472.22398509
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Data from p21 Loss Cooperates with INK4 Inactivation Facilitating Immortalization and Bcl-2–Mediated Anchorage-Independent Growth of Oncogene-Transduced Primary Mouse Fibroblasts
Autor: Dale S. Haines, E. Premkumar Reddy, Xavier Graña, Christopher J. Carbone
The INK4 and CIP cyclin-dependent kinase (Cdk) inhibitors (CKI) activate pocket protein function by suppressing Cdk4 and Cdk2, respectively. Although these inhibitors are lost in tumors, deletion of individual CKIs results in modest proliferation def
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e640fe5f266e600fd9387adec8cdde1
https://doi.org/10.1158/0008-5472.c.6496293.v1
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Abstract P126: FXR1 Regulates Vascular Smooth Muscle Cell Cytoskeletal Dynamics By Multiple Mechanisms
Autor: Amanda St Paul, Kyle Preston, Cali Corbett, Tani Leigh, Rachael Okune, Sheri E Kelemen, Satoru Eguchi, Dale S Haines, Michael Autieri
Publikováno v: Hypertension. 79
Introduction: Hypertension is a major risk factor for cardiovascular disease and stroke. Optimally treated hypertensive patients have a 50% greater cardiovascular risk than untreated normotensive subjects, presenting a need for additional targets. Va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::640655143f40e114ae9a7e7354372ada
https://doi.org/10.1161/hyp.79.suppl_1.p126
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FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells
Autor: Dale S. Haines, Mitali Ray, Christine N. Vrakas, Michael V. Autieri, Sheri E. Kelemen, Michael J. Sweredoski, Allison B. Herman, Annie Moradian
This work identifies the fragile-X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMCs). FXR1 was identified as an HuR-interacting protein by liquid chromatography-tandem mass spectrometry
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc9dc58b891e8e45b16167237cec62c
https://resolver.caltech.edu/CaltechAUTHORS:20180731-092548074
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9
Oncogenic Protein MTBP Interacts with MYC to Promote Tumorigenesis
Autor: Xi Chen, Hua Xiao, Maria Pia Arrate, Brian C. Grieb, Dale S. Haines, Christine M. Eischen, Stephen L. Beauparlant, Mark W. Gramling
Publikováno v: Cancer Research. 74:3591-3602
Despite its involvement in most human cancers, MYC continues to pose a challenge as a readily tractable therapeutic target. Here we identify the MYC transcriptional cofactors TIP48 and TIP49 and MYC as novel binding partners of Mdm2-binding protein (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f55eddcc09bf31727630479a9e022a
https://doi.org/10.1158/0008-5472.can-13-2149
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10
p97-Containing Complexes in Proliferation Control and Cancer: Emerging Culprits or Guilt by Association?
Autor: Dale S. Haines
Publikováno v: Genes & Cancer. 1:753-763
p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, abundant, and essential type II AAA ATPase that functions in numerous ubiquitin signaling–dependent processes. p97/Cd48 activities require a growing number of adaptor or a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf69cd7bb8e989ea01230afc18441db1
https://doi.org/10.1177/1947601910381381
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